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Application of green zanthoxylum volatile oil in the preparation of anti-inflammatory or analgesic drugs

A technology for volatile oil and volatile oil of Zanthoxylum bungeanum, which is applied in the field of biomedicine, can solve the problems such as the pharmacological activity of the volatile oil of Zanthoxylum bungeanum that has not been seen, and achieve the effect of reducing ear swelling.

Active Publication Date: 2022-04-15
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, the research on Zanthoxylum bungeanum is mainly focused on the cultivation technology, and there is no report on the pharmacological activity of the volatile oil of Zanthoxylum bungeanum in anti-inflammatory and analgesic aspects.

Method used

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  • Application of green zanthoxylum volatile oil in the preparation of anti-inflammatory or analgesic drugs
  • Application of green zanthoxylum volatile oil in the preparation of anti-inflammatory or analgesic drugs
  • Application of green zanthoxylum volatile oil in the preparation of anti-inflammatory or analgesic drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1、 9

[0029] Embodiment 1, the preparation method of the volatile oil part of Nine-leaf Green Zanthoxylum bungeanum

[0030]Nine-leaf green Zanthoxylum bungeanum is crushed into a coarse powder, and deionized water equivalent to 6 times the weight of the medicinal material is added, and under the condition of an oil bath at 130°C, the extract is heated and refluxed with a water distillation device for 6 hours to obtain the extract of the volatile oil. GCMS analysis was performed on this part, and the spectrogram results were as follows figure 1 As shown in Table 1, a total of 19 compounds were isolated, which can reflect the main chemical components of the volatile oil of Zanthoxylum bungeanum. The main compounds are alkanes, linalool and D-limonene.

[0031] Table 1. The main chemical components of the volatile oil of Zanthoxylum bungeanum

[0032]

Embodiment 2、 9

[0033] Example 2. Pharmacodynamic study on anti-inflammatory and analgesic effects of the volatile oil of Zanthoxylum bungeanum

[0034] 1. Xylene-induced ear swelling test (anti-inflammatory test)

[0035] (1) Select 48 SPF grade Kunming male mice weighing (18-22g) and carry out adaptive feeding for a period of one week. During the feeding period, the temperature is 25±1°C, and the light is cycled for 12 hours and the darkness is 12 hours. After one week of adaptive feeding, one group was randomly selected as the normal control group (Control), and the other groups were the model group (Model), the positive drug indomethacin group (Indometacin), the Oil-L group (the extract of volatile oil was low dosage group), Oil-M group (medium dose group of extracts from volatile oil parts), and Oil-H group (high dose group of extracts from volatile oil parts) were set to 100mg / kg, 200mg / kg and 300mg / kg respectively, and the positive drug ind The dose of domethacin is 5mg / kg.

[0036] ...

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Abstract

The invention discloses the application of the volatile oil of green peppercorns in the preparation of anti-inflammatory and analgesic drugs. Through research, it is found that the volatile oil parts of green peppercorns can reduce ear swelling induced by xylene and foot swelling induced by carrageenan, and improve carrageenan Abnormal expression of induced inflammatory factors such as TNF-α, IL-6, IL-1β, etc. At the same time, the volatile oil of Zanthoxylum bungeanum has an inhibitory effect on the writhing reaction caused by acetic acid and the foot-licking reaction caused by formalin, And reduce the release of formalin-induced serotonin, bradykinin, substance P and prostaglandin E2 and other pain-causing factors, indicating that the volatile oil of Zanthoxylum bungeanum has anti-inflammatory and analgesic effects, and its analgesic effect may be related to The anti-inflammatory effect is related to the inhibition of the release of inflammatory substances. The above research results provide a new option for the application of anti-inflammatory and analgesic drugs.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of the volatile oil fraction of Zanthoxylum bungeanum in the preparation of anti-inflammatory or analgesic drugs. Background technique [0002] Pain is an unpleasant feeling or emotional experience associated with actual or potential tissue damage, and is a subjective experience of the human body. Inflammatory pain refers to the pain caused by tissue damage caused by trauma, infection or arthritis, which is mainly manifested as allodynia, spontaneous pain, diffuse pain, hyperalgesia and accompanied by a certain degree of tissue pain. Edema. Statistics show that there are more than 100 million chronic pain patients in my country, and the number is on the rise. As a complex and intractable chronic pain, inflammatory pain has complex etiology and unclear mechanism. It will not only cause physical discomfort and physical impairment of patients, but also cause anxiety and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61P29/00A61K131/00
CPCA61K36/758A61P29/00
Inventor 陈敏宗伟廖志华曾庆鸿韦琳孟凡成
Owner SOUTHWEST UNIV
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