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Novel skin regeneration material and preparation method thereof

A new type of skin regeneration technology, applied in medical science, prosthesis and other directions, can solve the problems of insignificant antibacterial effect, complicated preparation process, and large amount of nano-silver, and achieve good biological safety, convenient use and strong applicability. Effect

Active Publication Date: 2014-08-27
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two patents use nano-silver as an antibacterial agent. Generally, in order to have a significant antibacterial effect, the amount of nano-silver used is relatively large, which leads to an increase in costs.
CN201310520955.5 discloses a functional dressing and its preparation method and application. It is composed of bioactive glass, alginate, chitosan and other components. The bioactive glass needs to go through steps such as high-temperature calcination and grinding, and the preparation process is complicated. And the dressing only has antibacterial effect of alginate and chitosan, and the antibacterial effect is not obvious, but if other antibacterial ingredients such as antibiotics and preservatives are used, problems such as drug resistance and secondary infection will occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A new type of skin regeneration material, including a coating layer, a medicament layer and a gel layer, the coating layer, the medicament layer and the gel layer in sequence from top to bottom. Wherein the gel layer consists of the following parts by weight:

[0040] 10 parts of alginate, 8 parts of chitosan, 1 part of oil microcapsule powder, 0.0001 part of nano-silver, and 100 parts of deionized water.

[0041] The preparation method of the oil microcapsule powder described therein is: adding 50 parts of linseed oil into 1 part by weight of maltodextrin, and 20 parts by weight of wall material, stirring evenly, at a homogeneous pressure of 25Mpa, The homogenization time is 20 minutes under the condition of 1 time of homogenization, the air inlet temperature is controlled at 140°C, and the exhaust air temperature is 100°C, and the oil microcapsule powder is obtained by spray drying.

[0042] The preparation method of novel skin regeneration material comprises the follo...

Embodiment 2

[0051] A new type of skin regeneration material, including a coating layer, a medicament layer and a gel layer, the coating layer, the medicament layer and the gel layer in sequence from top to bottom. Wherein the gel layer consists of the following parts by weight:

[0052] 30 parts of alginate, 25 parts of chitosan, 8 parts of oil microcapsule powder, 0.001 part of nano-silver, and 200 parts of deionized water.

[0053] The oil microcapsule powder is prepared by adding 60 parts of perilla seed oil into 10 parts by weight of maltodextrin and 50 parts of wall material, stirring evenly, and homogenizing at a homogenizing pressure of 35Mpa. The homogenization time is 30 minutes under the condition of 3 times, the air inlet temperature is controlled at 155° C., and the exhaust air temperature is 105° C. and spray-dried to obtain oil microcapsule powder.

[0054] Its preparation method comprises the following steps:

[0055] a: Chitosan was added into the acetic acid solution, s...

Embodiment 3

[0063] A new type of skin regeneration material, including a coating layer, a medicament layer and a gel layer, the coating layer, the medicament layer and the gel layer in sequence from top to bottom. Wherein the gel layer consists of the following parts by weight:

[0064] 25 parts of alginate, 10 parts of chitosan, 5 parts of oil microcapsule powder, 0.005 part of nano-silver, and 110 parts of deionized water.

[0065] The preparation method of the described oil microcapsule powder is to add 55 parts of olive oil into 7 parts by weight of maltodextrin and 50 parts of wall materials, stir evenly, and use a homogenization pressure of 25Mpa, and the number of times of homogenization for 3 times. The homogenization time is 30 minutes under the conditions, the air inlet temperature is controlled at 155° C., and the exhaust air temperature is 100° C. and spray-dried to obtain oil microcapsule powder.

[0066] Its preparation method comprises the following steps:

[0067] a: chi...

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PUM

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Abstract

The invention relates to a novel skin regeneration material and a preparation method thereof, and belongs to the biomedical material processing technical field. The skin regeneration material is divided into a drug agent layer and a gel layer, wherein the gel layer is composed of alginate, chitosan, a grease microcapsule powder, nano silver and deionized water. The preparation method comprises the steps of adopting a solution spinning method to obtain an alginate fiber, then pressing with a cladding material and a drug agent to obtain the novel skin regeneration material. The skin regeneration material is capable of protecting wound surfaces, relieving pain, stopping bleeding, diminishing inflammation, promoting growth of newly-born granulation tissues and epithelial cells, accelerating wound surface healing and the like, has the advantages of excellent antibacterial performance, good biological safety and the like, and is wide in application range and suitable for various wound surfaces with a large amount of exudates, various bleeding wounds and various chronic, infected and difficult-to-heal wound surfaces.

Description

technical field [0001] The invention relates to a novel skin regeneration material and a preparation method thereof, belonging to the technical field of medical material processing. Background technique [0002] Dressings are wound-wrapping supplies, medical materials used to cover sores, wounds or other damage. With the in-depth study of the pathophysiology of the wound healing process, people's understanding of the wound healing process has become more and more profound, which has led to the continuous improvement and development of medical wound dressings. High-tech medical dressings are gaining more and more attention in the world's medical and health fields. Traditional dressings such as medical absorbent cotton gauze and cotton pads are increasingly being used by new types of dressings because they cannot keep the wound moist, delay wound healing, have poor permeability barriers, and have poor hemostatic effects. Medical dressings instead. With the advancement of Chi...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/14A61L27/20A61L27/04A61L27/52A61L27/54
Inventor 郭瑞熊胜全
Owner BEOGENE BIOTECH GUANGZHOU
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