A kind of pickering emulsion with uniform particle size, preparation method and application thereof

An emulsion and particle size technology, applied in the field of materials, can solve the problems of unstable emulsion, wide particle size distribution, and uncontrollable emulsion particle size.

Active Publication Date: 2017-02-15
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The emulsion particle size distribution range prepared by the stirring method used in this document is wide, which easily leads to instability of the emulsion, and the particle size of the emulsion is uncontrollable

Method used

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  • A kind of pickering emulsion with uniform particle size, preparation method and application thereof
  • A kind of pickering emulsion with uniform particle size, preparation method and application thereof
  • A kind of pickering emulsion with uniform particle size, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Accurately weigh 0.5g of polylactic acid-glycolic acid copolymer (LA / GA75 / 25) particles, the molecular weight is 5kDa, the particle size is 10nm, 100nm, 500nm, 1μm, 10μm, 20μm, add 50mL of water phase to make it evenly dispersed , to obtain an aqueous suspension with a particle concentration of 1% (w / v). The pH of the aqueous phase is 8. Add 12.5 mL of hexadecane to the membrane emulsification device, and the oil-water ratio is 1:4. The device is equipped with an SPG membrane (distribution coefficient 15%) with a membrane pore size of 200 μm, which is submerged in the water phase. The nitrogen pressure is 0.1 kPa, the oil phase is pressed out through the SPG membrane, and directly enters the water phase, and a uniform emulsion is formed at a stirring rate of 50 rpm. Due to the biodegradability of polylactic acid-glycolic acid, the stability of the emulsion was studied by the emulsion centrifugation method, that is, the emulsion was centrifuged for 10 minutes under the...

Embodiment 2

[0110] Accurately weigh 0.5g polylactic acid-glycolic acid copolymer (LA / GA75 / 25) particles, its molecular weight is 5kDa, particle diameter is 100nm, add 50mL water phase, make it disperse evenly, obtain particle concentration to be 1% (w / v) an aqueous suspension. The pH of the aqueous phase is 8. Add 12.5 mL of hexadecane to the membrane emulsification device, and the oil-water ratio is 1:4. The device was equipped with a polytetrafluoroethylene membrane (distribution coefficient 20%) with a pore size of 200 μm, which was submerged in the water phase. The nitrogen pressure is 0.1kPa, the oil phase is pressed out through the polytetrafluoroethylene membrane, and directly enters the water phase, and a uniform emulsion is formed at a stirring rate of 50rpm. The emulsion type is O / W type, and the average particle size is 500μm. The CV is 13.1%. The emulsion particle size distribution is as figure 2 shown.

[0111] Due to the biodegradability of poly(lactic-co-glycolic aci...

Embodiment 3

[0113] Accurately weigh 0.5g polylactic acid-glycolic acid copolymer (LA / GA50 / 50) particles, its molecular weight is 200kDa, particle diameter is 100nm, add 50mL aqueous phase, make it disperse evenly, obtain particle concentration to be 1% (w / v) an aqueous suspension. The pH of the aqueous phase is 8. Add 12.5 mL of hexadecane to the membrane emulsification device, and the oil-water ratio is 1:4. The device is equipped with an SPG membrane (distribution coefficient 15%) with a membrane pore size of 200 μm, which is submerged in the water phase. The nitrogen pressure is 0.1kPa, the oil phase is pressed out through the SPG membrane, and directly enters the water phase, and a uniform emulsion is formed at a stirring rate of 50rpm. The emulsion type is O / W type, the average particle size is 500μm, and the CV is 13.4 %.

[0114] Due to the biodegradability of polylactic acid-glycolic acid, the emulsion stability was studied by emulsion centrifugation. After centrifugation und...

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Abstract

The invention discloses a Pickering emulsion with uniform particle size, a preparation method and an application thereof. The present invention uses solid particles as a stabilizer, which is dispersed in the water (or oil) phase and then emulsified with the oil (or water) phase, and then the formed pre-emulsion is passed through a membrane emulsification device to form a uniform and stable Pickering emulsion; or The dispersed phase (water phase or oil phase) is pressed through the pores of the membrane and enters the continuous phase (oil phase or water phase) in which solid particles are dispersed. Under the action of external force, the emulsion falls off from the pores of the membrane to form a uniform and stable Pickering emulsion. The process of the method is simple, and the properties of the emulsion are regulated by adjusting the ratio of water and oil phase, particle concentration, particle size and microporous membrane. The obtained emulsion is stable and the particle size is uniform and controllable. The use of it can reduce the toxicity to the human body and environmental pollution, and can be widely used in the fields of biomedicine, cosmetics, food, petroleum and wastewater treatment.

Description

technical field [0001] The invention relates to a Pickering emulsion and a preparation method and application thereof, in particular to a Pickering emulsion with uniform particle size and a preparation method thereof, belonging to the field of materials. Background technique [0002] Pickering emulsion is a new type of emulsion system in which solid particles replace traditional surfactants. Such as figure 1 As shown, the stabilization mechanism of the emulsion is mainly through the adsorption of solid particles on the oil-water interface to form a single-layer or multi-layer structure of solid particles, thereby stabilizing the emulsion. [0003] Compared with emulsions stabilized by traditional surfactants, it has outstanding advantages: (1) less toxic and side effects on the human body; (2) reducing environmental pollution; (3) strong emulsion stability. Therefore, Pickering emulsion has very important research and application value in the fields of food, cosmetics and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F3/08B01F17/00C09K23/00
Inventor 马光辉齐峰吴颉周炜清
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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