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Application of licoflavone extract in preparation of medicine for treating ulcerative colitis

A technology of ulcerative colitis and licorice flavonoids, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as the application of ulcerative colitis without extracts, and achieve full utilization and rich applications Field, good therapeutic effect

Active Publication Date: 2014-09-03
新疆维吾尔自治区中药民族药研究所 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] In the prior art, the application of licorice in the preparation of medicines for treating various diseases basically uses licorice and other Chinese herbal medicine compatibility components in order to achieve the purpose of solving various diseases, and there is no use of licorice flavonoids and extracts in Preparation of reports on the application of drugs for the treatment of ulcerative colitis. The present invention is guided by the activity of treating ulcerative colitis and has carried out the application research of the licorice flavonoids extract. After searching, there is no literature report on this aspect.

Method used

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  • Application of licoflavone extract in preparation of medicine for treating ulcerative colitis
  • Application of licoflavone extract in preparation of medicine for treating ulcerative colitis
  • Application of licoflavone extract in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment one: the preparation of licorice flavonoids extract

[0055] (1) Extract 8 kg of licorice residue with 15 times the amount of 80% ethanol solution at 80°C for 3 times, each time for 1.5 hours, combine the three extracts, concentrate under reduced pressure at 80°C to recover ethanol, dry at 60°C and pulverize to obtain the extract.

[0056] (2) The total flavonoid content is 34%.

Embodiment 2

[0057] Embodiment two: the preparation of licorice flavonoids extract

[0058] (1) Add 15 times the amount of 90% ethanol solution to 8 kg of licorice residue, soak for 30 minutes, extract twice at 85°C for 1.5 hours each time, combine the extracts, stand still to get the clarified liquid, recover ethanol under reduced pressure at 85°C, and obtain an aqueous suspension .

[0059] (2) Add hydrochloric acid solution to the aqueous suspension to adjust the pH to 3, let it settle for 2 hours, and take the precipitate to dry.

[0060] (3) The total flavonoid content is 44%.

Embodiment 3

[0061] Embodiment three: the preparation of licorice flavonoids extract

[0062] (1) Crush licorice, take 8kg and add 60% ethanol solution (15, 10, 10 times the amount) to extract 3 times at 85°C, 2h each time, recover ethanol under reduced pressure at 85°C until there is no alcohol, and set aside the aqueous solution at 10-20°C for precipitation , take the precipitate, wash with cold water, and dry the insoluble matter.

[0063] (2) The total flavonoid content is 28%.

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Abstract

The invention discloses an application of licoflavone extract in preparation of a medicine for treating ulcerative colitis. By utilizing a novel application of the licoflavone extract in the medicine aspect of treating the ulcerative colitis, the licoflavone extract has a better treatment effect on mouse ulcerative colitis caused by acetic acid compared with a positive control drug salazosulfapyridine and is expected to have high practical value in the preparation of the medicine for treating the ulcerative colitis, liquorice fat-soluble flavone extract in the licoflavone extract has a good application effect in preparation of the medicine for treating ulcerative colitis diseases, and chalcone substances in the licoflavone extract have obvious curative effects on treatment of the ulcerative colitis. The licoflavone extract can be extracted from liquorice and also can be extracted from residual dregs in which glycyrrhizic acid is extracted, the liquorice resources can be fully utilized, the liquorice residue resources are conveniently developed and utilized, the wastes are changed into valuable materials, and the application has wide application value.

Description

technical field [0001] The present invention relates to the technical field of medicine. Specifically, the present invention relates to the technical field of application of licorice flavonoids extracts in the preparation of medicines for treating ulcerative colitis. Furthermore, the present invention specifically relates to the use of common licorice flavonoids in the preparation of The technical field of application of medicines for treating ulcerative colitis. Background technique [0002] Flavonoids are a class of polyphenols widely distributed in nature. Hundreds of different types of flavonoids have been found to have a wide range of biological and pharmacological activities. A large number of studies have shown that flavonoids have the functions of scavenging free radicals, anti-oxidation, anti-mutation, anti-tumor, anti-bacterial, anti-virus, regulating immunity, preventing and curing arteriosclerosis, and lowering blood sugar. With the development of industry and ...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P1/04A61P1/00
Inventor 倪慧贾晓光曹丽斯建勇刘冬羽张娟卿德刚孙宇
Owner 新疆维吾尔自治区中药民族药研究所
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