Rhodamine-containing lactam group micromolecule pH fluorescent probe and synthetic method

A fluorescent probe, Minglactam technology, applied in chemical instruments and methods, luminescent materials, organic chemistry, etc., can solve problems such as hydrogen ion fluorescence response interference, and achieve the effect of good anti-interference ability
CN104017569AInactive Publication Date: 2014-09-03SUZHOU UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SUZHOU UNIV OF SCI & TECH
Publication Date
2014-09-03
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a rhodamine-containing lactam group micromolecule pH fluorescent probe, a synthetic method comprises the following steps: reacting 2-position rhodamine of which is provided with a carboxylic group and ethene diamine to form lactam, then reacting with a formyl-containing substance, and synthesizing the micromolecule pH fluorescent probe which has specific fluorescence response to H<+>. The pH fluorescent probe synthetic method has the advantages of simple operatrion, easy purification and little reaction loss.
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Description

technical field

[0001] The invention relates to a small molecule pH fluorescent probe containing a rhodamine lactam group and a synthesis method. Background technique

[0002] Due to the high sensitivity, high selectivity, fast response, and simple operation of fluorescent probes, the pH value can be monitored in real time. Therefore, fluorescent pH probes provide powerful detection tools for studying the effects of pH changes on physiological activities, and are widely used in analytical chemistry, bioanalytical chemistry, cell biology, and medicine.

[0003] There is a lactam spiro ring structure in the rhodamine-based fluorescent probe molecule, and the fluorescence switch is controlled by the switch of the spiro ring. The spiro ring switch of the rhodamine-based probe can also be controlled by the pH value of the solution, and has a very strong response ability , after interacting with specific ions, it can transform from a non-fluorescent and colorless lactam spiro-rin...

Claims

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