Angelica wall-broken preparation

An angelica and preparation technology, applied in the field of traditional Chinese medicine, can solve the problems of low stability, moisture absorption and oxidation of broken wall powder, easy loss of efficacy, etc. Effect

Active Publication Date: 2014-09-24
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects in the prior art that the broken wall powder is easy to absorb moisture and be oxidized, the stability is not high, and the drug effect is easily lost, and a kind of angelica broken wall preparation is provided.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take Angelica sinensis medicinal materials, coarsely pulverize it to a coarse powder of about 100 mesh, and then ultrafinely pulverize it into a powder with a particle size of about 24 μm in 90% of the ultrafine powder. Add ethanol-water solution (the mass fraction of ethanol is 50%). ) Soft material is made by wet method, the ratio of solution to ultrafine powder is 0.44:1 (by weight), after mixing, pre-installed with a 10-mesh sieve, using an extrusion speed of 50r / min and an extrusion force of 1MPa to make wet granules , the wet granules are placed in a hot air circulation oven, the drying temperature is set to 65°C, and dried for 3.0 hours to dryness.

[0030]

[0031] Note: The full score is 10.

Embodiment 2

[0033] Take the pure medicinal materials of Angelica sinensis, coarsely pulverize it to a coarse powder of about 100 mesh, and then ultrafinely pulverize it into a powder with a particle size of about 35 μm in 90% of the ultrafine powder, and add ethanol-water solution (the mass fraction of ethanol is 60%). ) Soft material is prepared by wet method, the ratio of solution to ultrafine powder is 0.48:1 (by weight), after mixing, pre-installed with a 10-mesh sieve, using an extrusion speed of 50r / min and an extrusion force of 0.9MPa to make wet Granules, wet granules are transferred into a vacuum microwave drying oven, set a drying temperature of 45°C, and dry for 0.75h to dryness.

[0034]

[0035] Note: The full score is 10.

Embodiment 3

[0037] Take the pure medicinal materials of Angelica sinensis, coarsely pulverize it to a coarse powder of about 100 mesh, and then ultrafinely pulverize it into a powder with a particle size of about 32 μm in 90% of the ultrafine powder, and add ethanol-water solution (the mass fraction of ethanol is 95%). ) Soft material is prepared by wet method, the ratio of solution to ultrafine powder is 0.66:1 (by weight), after mixing, pre-installed with a 30-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet Granules, wet granules are placed in a hot air circulation oven, set a drying temperature of 65°C, and dry for 2.5 hours to dryness.

[0038]

[0039] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese medicine preparations, and in particular relates to an angelica wall-broken preparation. The angelica wall-broken preparation is prepared as follows: crushing angelica into broken powder, then granulating by use of an ethanol-water wet method, extruding for forming at a certain speed and drying, and the prepared angelica wall-broken preparation is high in bioavailability, strong in stability, and good in disintegration.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a broken wall preparation of Angelica sinensis. Background technique [0002] Ultrafine pulverization technology is a new technology that has developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells, and only part of the active ingredients can be released when the conventional decoction pieces are decoctioned, and the utilization rate of the active ingredients is 10-30%. The rate of cell wall breaking will reach 86.7%, which improves the dissolution of active ingredients in medicinal materials, greatly enhances its efficacy, and the utilization rate of active ingredients is over 90%, which reduces the amount of medicinal materials used and protects medicinal materials resources. quality to increase efficacy. However, the current main ultra-fine pulverization technology is still at the stage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K47/10A61K9/16A61K125/00
Inventor 成金乐陈勇军苏观凤陈金梅梁燕玲
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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