Novel natriuretic peptide chimera CNAAC with cardiac failure resistance

Abstract

The invention discloses a novel natriuretic peptide chimera CNAAc which has the functions of vasodilation, diuresis and myocardial protection. The CNAAc is a novel natriuretic peptide molecule formed by adding an annular structure of ANP (Atriopeptin) and c-terminus on an amino terminal of CNP (C-type Natriuretic Peptide) (as shown in the drawing). The natriuretic peptide chimera has the functions of endothelium-independent vasodilation and strong diuresis. The vasodilation function of the natriuretic peptide chimera CNAAc is greatly superior to that of the natural natriuretic peptide ANP or CNP, and the natriuretic peptide chimera CNAAc possibly exerts the effec through an NPR / cGMP / PKG signal channel. The CNAAc can be used for obviously inhibiting the cardiac hypertrophy of a rat during the generation of the cardiac failure and improving the myocardial enzymology indexes and the cardiac functions of the rat so as to obviously relieve the myocardial infarction degree and the myocardial fibrosis degree of the rat with the cardiac failure. The novel natriuretic peptide chimera with the functions of the myocardial protection and the cardiac failure resistance can be applied to academic research and can be possibly prepared into novel medicines for preventing and treating cardiac failure in clinical application. Thus, the novel natriuretic peptide chimera has good scientific research values and clinical application prospects.

Description

technical field [0001] The invention relates to the fields of basic research and clinical research of using novel natriuretic peptide drugs to prevent and treat heart failure. Background technique [0002] Cardiovascular and cerebrovascular diseases are recognized as the "No. 1 killer" of human health in the world, and heart failure is the almost inevitable outcome of many organic heart diseases such as myocardial infarction, cor pulmonale, hypertrophic cardiomyopathy, etc., a serious threat human health. The natriuretic peptide family has been widely used in basic and clinical research on heart failure because of its diverse effects such as significant natriuresis, diuresis, vasodilator and anti-proliferation. [0003] The natriuretic peptide family is a family of endogenous peptides with similar structures, and its members include atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (C-type natriuretic peptide, CNP) and D-type nat...

AI Technical Summary

Problems solved by technology

Artificially synthesized ANP and BNP analogues have been widely used in HF treatment, but their application has been limited due to problems such as low chemical synthesis efficiency, high cost, and easy degradation by the body.

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