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Anti-tumor plant extract composition as well as preparation method and application thereof

A technology of plant extraction and composition, which is applied in the field of anti-tumor plant extract composition and its preparation, achieving the effect of less clinical dosage, high content of active ingredients and stable process

Inactive Publication Date: 2014-10-01
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the use of red root grass extract, southern Schisandra extract, Scutellaria barbata extract and Astragalus extract for the interaction and compatibility of traditional Chinese medicine compositions to prepare anti-tumor drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Prescription: 35kg of red root grass extract, 30kg of southern Schisandra extract, 25kg of Scutellaria barbata extract, and 10kg of Astragalus extract.

[0018] 2. Preparation method:

[0019] (1) Red root grass extract: Take red root grass powder, put it in 5 extraction devices in series on average, add 15 times the amount of 75% edible ethanol as the extraction solvent, and extract 2 times by continuous countercurrent method, each extraction 3 hour, combine the extracts, reclaim ethanol, centrifuge and get the supernatant, and then carry out microfiltration and ultrafiltration in the roll-type membrane separation equipment. The operating pressure is 0.2MPa. Elute the impurities, then elute with 60% edible ethanol, collect the ethanol eluate, concentrate, spray dry to obtain the red root grass extract, and set aside;

[0020] (2) Schisandra chinensis extract: Grind schisandra chinensis, add 6 times the amount of hot water and ultrasonically extract 3 times, extract...

Embodiment 2

[0025] Acute toxicity test of the plant extract composition of the present invention

[0026] 1. Materials

[0027] Medicine: the plant extract composition of Example 1, self-made.

[0028] Animals: 12 Kunming mice, half male and half male, weighing 20-30 g.

[0029] 2. Method

[0030] The mice were randomly divided into 3 groups, and after fasting for 12 hours, 0.2g / ml capsule preparation of the plant extract composition of the present invention was given 10, 20, 40ml / kg body weight by intragastric administration respectively, and the dosage was 2, 4, 8g / kg , observed continuously for 2 days, no obvious toxic reaction was seen.

[0031] 3. Conclusion

[0032] No death occurred in this experiment. It is speculated that the capsule of the plant extract composition of the present invention has low toxicity, so the maximum tolerated dose test was carried out.

Embodiment 3

[0034] Maximum tolerance test of the plant extract composition of the present invention

[0035] 1. Materials

[0036] Medicine: the plant extract composition of Example 1, self-made.

[0037] Animals: 24 Kunming mice, half male and half male, weighing 20-30g,

[0038] 2. Method

[0039] Take healthy Kunming mice, fast for 12 hours, and give the capsule preparation of the plant extract composition of the present invention by intragastric administration according to the dosage of 10g / kg and the dosage of 40ml / kg. After gavage, the toxicity and death of the mice were closely observed. After 4 hours, the observation was changed to once a day for 14 consecutive days. After intragastric administration of the capsule preparation of the plant extract composition of the present invention, no abnormal changes were seen within 4 hours, and within 14 days, the mice had no abnormal changes in coat color, diet, body weight, and behavioral activities. After the observation, the mice wer...

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Abstract

The invention relates to an anti-tumor plant extract composition as well as a preparation method and application thereof. The plant extract composition is prepared from the following components in percentage by weight: 20-45% of salvia prionitis extract, 15-35% of kadsura longepedunculata extract, 10-20% of scutellariae barbatae extract and 5-10% of astragalus extract. Pharmacological experiment indicates that the plant extract composition provided by the invention has major functions. Besides, the preparation method for the plant extract composition preparation disclosed by the invention is controllable in quality, high in active ingredient content, and suitable for industrial production.

Description

Technical field [0001] The present invention is a biopharmaceutical technology field, and the plant extract composition and its preparation methods and applications involving an antitumor are specifically involved. Background technique [0002] Tumor is the most common type of common diseases and diseases that endanger human health. The most common treatment is surgery, chemotherapy, and radiotherapy, while chemotherapy has a large side effect due to toxicity and affects patients' quality of life.In recent years, the treatment of tumors in traditional Chinese medicine is called unique therapy. Traditional Chinese medicine believes that blood stasis blocked, phlegm cohesion, internal heat poisoning, and positive qi deficiency are the pathogenesis of tumor.The treatment of anti -cancer treatment mainly includes four basic rules: righteousness solid, clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and softness.The mechanism of traditional Chines...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61P35/00
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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