Small molecule peptide with antibacterial antiviral activity and active modifier of small molecule peptide

A technology of antiviral activity and small molecular peptides, which can be applied in antiviral agents, antibacterial agents, antifungal agents, etc., can solve the problems of less AMPs drugs, bioavailability, toxicity stability, and production costs, and achieve a wide range of antibacterial activities Effect

Active Publication Date: 2014-10-01
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although AMPs have certain advantages, so far few AMPs drugs have met the requirements of clinical practicality
Because AMPs have problems such as bioavailability, toxicity, stability and production cost

Method used

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  • Small molecule peptide with antibacterial antiviral activity and active modifier of small molecule peptide
  • Small molecule peptide with antibacterial antiviral activity and active modifier of small molecule peptide
  • Small molecule peptide with antibacterial antiviral activity and active modifier of small molecule peptide

Examples

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Embodiment 1

[0064] 1. Small molecule peptides and their active modifiers

[0065] (1) Small molecule peptides and their active modifiers

[0066] The antibacterial and antiviral small molecule peptide of the present invention is a polypeptide composed of 3-7 amino acids with KWWK and KWK as basic motifs. The general formula of the amino acid sequence of a series of antimicrobial small molecular peptides obtained according to the basic amino acid sequence KWWK and KWK is X 0-3 (R / K / O / D ab )X 0-1 W 1-2 (R / K / O / D ab ) 0-1 x 0-1 ; Wherein X is selected from amino acid R, K, W, any in I; X 0-3 Indicates any 0-3 of amino acids R, K, W, and I; X 0-1 Indicates any 0-1 of amino acids R, K, W, I; W 1-2 Indicates 1 or 2 amino acids W; (R / K / O / D ab ) 0-1 Indicates 0 or 1 amino acid R or K or O or D ab , where D ab For 2,4-diaminobutanine. Among them, 17 sequences with better antibacterial and antiviral effects are shown in Table 1.

[0067] Table 1 Amino acid sequence list of antimicrobi...

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Abstract

The invention discloses a small molecule peptide with antibacterial antiviral activity and an active modifier of the small molecule peptide. An amino acid sequence of the small molecule peptide is formed by 3-7 amino acids; a general formula of the amino acid sequence is X[0-3](R/K/O/D[ab])X[0-1]W[1-2](R/K/O/D[ab])[0-1]X[0-1], wherein X is one of the amino acids R, K, W and I; X[0-3] is any 0-3 of R, K, W and I; X[0-1] is any 0-1 of R, K, W and I; W[1-2] represents one or two Ws; (R/K/O/D[ab])[0-1] represents zero or one amino acid R or K or O or Dab; D[ab] is a 2,4-diamido-butyric acid. The experiment proves that the small molecule peptide or the active modifier thereof disclosed by the invention has good antibacterial antiviral effects, and has important application value in preparation of a drug, a sanitizer, a detergent, a corrosion remover or a packaging material for removing bacteria, fungi or viruses.

Description

technical field [0001] The present invention relates to novel antibacterial peptides and derivatives thereof, in particular to small molecule peptides with antibacterial and antiviral activities and their activity modifiers. Background technique [0002] Bacterial resistance to traditional antibiotics has become a global problem, and the development of new antibacterial drugs is urgently needed. To solve this problem, antimicrobial peptides (AntimicrobiaL peptides AMPs) have become potential therapeutic agents for infectious diseases caused by drug-resistant pathogens. Antimicrobial peptides are polypeptide substances with antibacterial activity produced by organisms when they are invaded by external pathogenic microorganisms. They are usually composed of 12-45 amino acids and have a molecular weight of about 40kD. They are an important part of the nonspecific immunity of organisms. The primary structure of antimicrobial peptides has typical characteristics, that is, the N-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/09C07K5/11C07K7/06A61K38/06A61K38/07A61K38/08A61P31/04A61P31/10A61P31/12A61P31/16A61P31/18C12N15/11
Inventor 何坚刘叔文林冬果方堉欣王静瑜
Owner SOUTHERN MEDICAL UNIVERSITY
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