Small molecule peptide with antibacterial antiviral activity and active modifier of small molecule peptide

A technology of antiviral activity and small molecular peptides, which can be applied in antiviral agents, antibacterial agents, antifungal agents, etc., can solve the problems of less AMPs drugs, bioavailability, toxicity stability, and production costs, and achieve a wide range of antibacterial activities Effect
CN104072579AActive Publication Date: 2014-10-01SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2014-10-01

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Abstract

The invention discloses a small molecule peptide with antibacterial antiviral activity and an active modifier of the small molecule peptide. An amino acid sequence of the small molecule peptide is formed by 3-7 amino acids; a general formula of the amino acid sequence is X[0-3](R / K / O / D[ab])X[0-1]W[1-2](R / K / O / D[ab])[0-1]X[0-1], wherein X is one of the amino acids R, K, W and I; X[0-3] is any 0-3 of R, K, W and I; X[0-1] is any 0-1 of R, K, W and I; W[1-2] represents one or two Ws; (R / K / O / D[ab])[0-1] represents zero or one amino acid R or K or O or Dab; D[ab] is a 2,4-diamido-butyric acid. The experiment proves that the small molecule peptide or the active modifier thereof disclosed by the invention has good antibacterial antiviral effects, and has important application value in preparation of a drug, a sanitizer, a detergent, a corrosion remover or a packaging material for removing bacteria, fungi or viruses.
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Description

technical field

[0001] The present invention relates to novel antibacterial peptides and derivatives thereof, in particular to small molecule peptides with antibacterial and antiviral activities and their activity modifiers. Background technique

[0002] Bacterial resistance to traditional antibiotics has become a global problem, and the development of new antibacterial drugs is urgently needed. To solve this problem, antimicrobial peptides (AntimicrobiaL peptides AMPs) have become potential therapeutic agents for infectious diseases caused by drug-resistant pathogens. Antimicrobial peptides are polypeptide substances with antibacterial activity produced by organisms when they are invaded by external pathogenic microorganisms. They are usually composed of 12-45 amino acids and have a molecular weight of about 40kD. They are an important part of the nonspecific immunity of organisms. The primary structure of antimicrobial peptides has typical characteristics, that is, the N-...

Claims

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