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Method for preparation of flomoxef in vertical logistics system

A technology of logistics system and crystallization method, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low sterility assurance level, and achieve the effect of improving sterility assurance level.

Inactive Publication Date: 2014-10-29
CHONGQING LUMMY PHARMA
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Problems solved by technology

The traditional method adopts plane operation. Since the material obtained in the process of solid-liquid separation is powder, it will inevitably be exposed to the air during the transfer process. Although 100-level laminar flow protection is used during the exposure process, due to the Manual operation is still required for remaining. In fact, exposed materials cannot be transferred in a dynamic A-level clean environment, and the level of sterility assurance is low.

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  • Method for preparation of flomoxef in vertical logistics system

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Embodiment Construction

[0023] The present invention will be further described in detail below in conjunction with the drawings and specific embodiments. figure 1 It is a schematic diagram of the process flow chart for preparing sterile fluoxefox crude drug by vertical logistics full aseptic docking solvent crystallization method, such as figure 1 Shown.

[0024] The method for preparing fluoxef in a vertical logistics system is specifically: adding a crystallization solvent to the fluoxef reaction solution, after the crystallization step is completed, the solid-liquid separation is carried out, and the separated solid is transferred by gravity The crystallization solvent is a mixed liquid of acetone and dichloromethane. In the method for preparing fluoxef in a vertical logistics system, the crystallization solvent is mixed with acetone and dichloromethane in a volume ratio of 2:1. The solid-liquid separation device is specifically a sterile horizontal scraper centrifuge. The solids are transferred a...

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Abstract

The invention relates to the pharmaceutical field, especially to production of bulk drugs by a solvent crystallization method, and also relates to an aseptic logistics method. The method for preparation of flomoxef in a vertical logistics system includes: adding a crystallization solvent into a flomoxef reaction solution, performing crystal growing, then conducting solid-liquid separation, and transferring the separated solid by gravity. The crystallization solvent is mixed solution of acetone and dichloromethane. With the method provided by the invention, the pollution problem caused by environmental exposure in a material transfer process is avoided, and the prepared bulk drug has a high aseptic level. In addition, the logistics system with gravity as the main driving force has the characteristics of high transport efficiency and low cost.

Description

Technical field [0001] The present invention relates to the field of pharmacy, in particular to the production of bulk drugs by solvent crystallization method, and also to aseptic logistics method. Background technique [0002] Fluoxef is the third-generation cephalosporin for injection. It is characterized by strong activity against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, and is against other gram-positive bacteria and gram-negative bacteria. The bacteria also have good broad-spectrum activity. It has high stability to β-lactamase. In the solvent crystallization method, the production of aseptic fluoxefone raw materials usually involves the processes of dissolution, aseptic filtration, crystallization, solid-liquid separation, drying, crushing, and packaging. The traditional method uses plane operation. Because the material obtained through the solid-liquid separation process is powder, it will inevitably be exposed to the a...

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Application Information

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IPC IPC(8): C07D505/20C07D505/02
CPCC07D505/20C07D505/02C07H1/06C07H15/16
Inventor 邱宇周和平唐伟业何炯荣张开飞
Owner CHONGQING LUMMY PHARMA
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