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Emulsion cefquinome sulfate injection and preparation method thereof

A technology of cefquinoxime sulfate and emulsion type, which is applied in the field of emulsion type cefquinoxime sulfate injection and its preparation, can solve the problems of product precipitation and large particle size, and achieves improved stabilization effect, small particle size and good stability Effect

Inactive Publication Date: 2014-11-05
CHONGQING ACAD OF ANIMAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, all the suspensions on the market, the product precipitates, and the particle size is large

Method used

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  • Emulsion cefquinome sulfate injection and preparation method thereof
  • Emulsion cefquinome sulfate injection and preparation method thereof
  • Emulsion cefquinome sulfate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of embodiment 1 injection of the present invention

[0014] Weigh 1.25 g of cefquinome sulfate, 0.5 g of Tween-60, 1.0 g of methyl cellulose, and 1.0 g of sodium citrate in a beaker, then add water for injection at 60°C to make the volume to 50 mL, and pass through an emulsifying machine to high-speed shear Cut and emulsify for 5 minutes, and finally sterilize by 3KGY of 60Co-Y rays to make emulsion type cefquinome sulfate injection.

[0015] Get the cefquinome sulfate emulsion, add in the laser particle size analyzer, measure its particle diameter, the result is shown in figure 1 , The average particle size was determined to be 0.941 μm.

Embodiment 2

[0016] The preparation of embodiment 2 injections of the present invention

[0017] Weigh 1.25g of cefquinome sulfate, 0.6g of Tween-65, 1.2g of hydroxypropyl methylcellulose, and 1.1g of sodium tartrate into a beaker, then add water for injection at 60°C to 50mL, and pass through an emulsifier at high speed Shearing and emulsifying for 5 minutes, and finally sterilizing by 3KGY of 60Co-Y rays to make emulsion type cefquinome sulfate injection.

[0018] Get the cefquinome sulfate emulsion, add in the laser particle size analyzer, measure its particle diameter see figure 2 , The average particle size was determined to be 0.805 μm.

Embodiment 3

[0019] The preparation of embodiment 3 injections of the present invention

[0020] Weigh 1.25g of cefquinome sulfate, 0.7g of Tween-80, 0.4g of carbomer 940, and 1.5g of aluminum chloride in a beaker, then add water for injection at 60°C to the volume to 50mL, and use an emulsifier to shear at high speed Emulsified for 5 minutes, and finally sterilized by 3KGY of 60Co-Y rays to make emulsion type cefquinome sulfate injection.

[0021] Get cefquinoxime sulfate emulsion, add in the laser particle size analyzer, measure its average particle diameter as 1.085 μ m.

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Abstract

The invention specifically relates to an emulsion cefquinome sulfate injection and a preparation method thereof, belonging to the technical field of veterinary antibiotic preparations. The invention provides the emulsion cefquinome sulfate injection to overcome technical problems. According to a technical scheme in the invention, the emulsion cefquinome sulfate injection comprises the following raw materials: cefquinome sulfate, 2.5% g / mL; an emulsifier, 0.1 to 2% w / w; a suspending aid, 0.1 to 10% w / w; deflocculant, 0.1 to 10% w / w; and balancing injection water. The invention further provides a preparation method for the injection. The injection is uniformly dispersed, has a small particle size, does not settle in a long period of time and has wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug antibiotic preparations, in particular to an emulsion-type cefquinome sulfate injection and a preparation method thereof. Background technique [0002] Cefquinome sulfate, chemical name: (6R,7R)-7-[(Z)-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(5,6, 7,8-Tetrahydroquinolinyl-1-methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-carboxylate, white, Off-white to light yellow powder. Cefquinome sulfate is the fourth-generation cephalosporin antibiotic drug for animals. Serratia marcescens) has strong antibacterial activity, and is widely used in pigs, cattle respiratory diseases, mastitis and endometritis in dairy cows and sows; poultry is caused by recalcitrant E. As well as the treatment of diarrhea, diarrhea, pericarditis and perihepatitis caused by staphylococcus, etc., it has many advantages such as broad antibacterial spectrum, strong antibacterial effect, less dosage, long plasm...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/546A61K47/34A61K47/38A61K47/24A61P31/04A61K47/32A61K47/36
Inventor 陈诚王建华
Owner CHONGQING ACAD OF ANIMAL SCI
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