New application of resveratrol derivative

A technology of resveratrol and derivatives, applied in the field of medicine, can solve problems such as diarrhea and side effects, and achieve the effects of alleviating and hyperleptinemia, promoting energy metabolism and simple operation.

Inactive Publication Date: 2014-11-19
安树君
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Problems solved by technology

Most of the current weight loss ...

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  • New application of resveratrol derivative
  • New application of resveratrol derivative
  • New application of resveratrol derivative

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Embodiment Construction

[0016] The new application of the resveratrol derivatives of the present invention, the resveratrol derivatives involved can be extracted from natural medicines such as Tibetan rhubarb, Hetao rhubarb, medicinal rhubarb, Tangut rhubarb, Polygonum cuspidatum, Polygonum multiflorum and other traditional Chinese medicines. Can be artificially synthesized.

[0017] The resveratrol derivative of the present invention can stabilize mast cells to reduce the levels of inflammatory mediators and free fatty acids in obese rats, reduce hyperinsulinemia and hyperleptinemia, promote energy metabolism in adipose tissue, and realize weight loss in obese rats.

[0018] The structural formula of the resveratrol derivative of the present invention is as follows:

[0019]

[0020] The molecular formula of the resveratrol derivative of the above molecular structure is C20H22O9, the molecular weight is 406, the degree of unsaturation n=10, and its name is 3'-hydroxy resveratrol, 4'-O-β-D-glucopy...

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Abstract

The invention relates to a new application of a resveratrol derivative, the resveratrol derivative has effects for stabilizing mast cells, reducing obesity rat inflammatory mediator and free fatty acid levels, mitigating hyperinsulinemia and hyperleptindemia, promoting energy metabolism of adipose tissue, realizing fat-reducing effect; a molecule structural formula of the resveratrol derivative is as follows, a molecular formula of the resveratrol derivative with the above molecule structural formula is C20H22O9, the molecular weight is 406, degree of unsaturation n is 10, and a name of the is 3'-hydroxy resveratrol, 4'-O-beta-D-pyranoglucoside. the resveratrol derivative has effects for stabilizing mast cells, reducing obesity rat inflammatory mediator and free fatty acid levels, mitigating hyperinsulinemia and hyperleptindemia, promoting energy metabolism of adipose tissue, realizing fat-reducing effect; the resveratrol derivative has the advantages of obvious curative effect, no toxicity, no side effect, simple and convenient extraction, low cost and high extraction efficiency.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of a resveratrol derivative. Background technique [0002] Obesity is a chronic inflammatory disease that can cause insulin resistance, and even become a high-risk factor for type 2 diabetes, cardiovascular disease and lipid metabolism disorders. In recent years, more and more studies on obesity have focused on the field of immune inflammation. Macrophages are the earliest inflammatory cells discovered in adipose tissue. The discovery of adipose tissue macrophages (Adipose tissue macrophage, ATM) provides a research direction for the relationship between obesity and inflammation. It is positively correlated. The proportion of ATM in all cells of adipose tissue in normal people is less than 10%, but it can be as high as 40% in obese state. ATM is the main source of pro-inflammatory factors in adipose tissue, and it is important to support obesity as a chronic in...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P3/04C07H15/203C07H1/08
Inventor 安树君
Owner 安树君
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