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Application of histone deacetylase inhibitors in preparing osteoblast differentiation preparation of odontogenic stem cells

A technology of sirtuin and osteogenic differentiation, applied in the direction of organic active ingredients, non-embryonic pluripotent stem cells, bone/connective tissue cells, etc., can solve the problem that the pathogenesis of periodontitis has not been completely resolved, and obvious tissue regeneration effects cannot be achieved And other issues

Inactive Publication Date: 2014-11-19
STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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Problems solved by technology

Although the research on the etiology of periodontal disease continues to deepen, the pathogenesis of periodontitis has not been fully resolved. At present, it is believed that plaque microorganisms and the immune inflammatory response of the host are the main reasons.
Basic periodontal treatment such as mechanical removal of dental plaque is currently the main measure for the treatment of periodontitis. Mechanical treatment can effectively control periodontal inflammation, but simple application cannot achieve significant tissue regeneration effects

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  • Application of histone deacetylase inhibitors in preparing osteoblast differentiation preparation of odontogenic stem cells
  • Application of histone deacetylase inhibitors in preparing osteoblast differentiation preparation of odontogenic stem cells
  • Application of histone deacetylase inhibitors in preparing osteoblast differentiation preparation of odontogenic stem cells

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Embodiment Construction

[0049] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0050] The healthy and inflammatory gingival mesenchymal stem cells and apical papilla stem cells used in this specific embodiment are all obtained from the tissues of outpatients in Stomatological Hospital of Tianjin Medical University, and all have obtained the consent of the patients, in line with the oral treatment procedures and the ethics committee Require. Healthy gum tissue is taken from healthy periodontal patients aged 20-55, probing depth (PD) ≤ 3mm, no loss of attachment, no bleeding and redness of the gums, no systemic disease, no smoking, third molar extraction or crown extension surgery is required Patients with chronic periodontitis aged 20-55 were selected for gingival inflammation, and the inclusion criteria were: ① Probing...

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Abstract

The invention relates to an application of histone deacetylase inhibitors in preparing an osteoblast differentiation preparation of odontogenic stem cells. The application provided by the invention has a very important and profound significance to the histone deacetylase inhibitors in changing the acetylization of mesenchymal stem cells, changing cell epigenetics by applying to a medicament, treating diseases such as periodontitis, peri-implantitis and the like, and promoting bone tissue regeneration. The two histone deacetylase inhibitors provided by the invention can be used for promoting the regeneration of bone tissues of patients suffering periodontitis, bone tissue defect and peri-implantitis so as to make up the defects of bone tissue regeneration caused by conventional treatment methods such as guide tissue regeneration (GTR), tooth periapical curettage, bone substitute application, distraction osteogenesis and the like.

Description

technical field [0001] The invention belongs to the field of dental preparations, and relates to the application of a histone deacetylase inhibitor in the preparation of osteogenic differentiation preparations of dental stem cells. Background technique [0002] Periodontitis is a common and multiple chronic infectious disease of periodontal tissue, which is the main cause of tooth loss in adults. Although the research on the etiology of periodontal disease continues to deepen, the pathogenesis of periodontitis has not been fully resolved. At present, it is believed that plaque microorganisms and the immune inflammatory response of the host are the main reasons. Basic periodontal treatment such as mechanical removal of dental plaque is currently the main measure for the treatment of periodontitis. Mechanical treatment can effectively control periodontal inflammation, but simple application cannot achieve significant tissue regeneration effects. Mesenchymal stem cells (Mesenc...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0775C12N5/074A61K31/165A61K47/36A61P1/02
Inventor 刘大勇高平贾智张旭肖蕊冯春月王月君
Owner STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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