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Split type suppository as well as preparation method and use thereof

A split-type suppository technology, which is applied in suppository delivery, non-active ingredient medical preparations, pharmaceutical formulas, etc., can solve the problems of split-type suppositories and achieve high stability of the suppository body, reduce absorption, and smooth surface

Active Publication Date: 2014-11-26
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the suppositories or vaginal expansion suppositories currently on the market have not yet had split suppositories (that is, nest-type suppositories), so there is an urgent need to provide a split suppository to avoid drug regulatory approval in turn.

Method used

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  • Split type suppository as well as preparation method and use thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0046] A split type suppository, which includes a split type suppository including a plug body with grooves and a tampon separated from the plug body; the plug body is mainly composed of metronidazole and semi-synthetic fatty acid glycerides, tallow fat and xylitol The mixture of anhydride monostearate; the groove is composed of the side wall of the groove and the bottom of the groove; the cross-sectional diameter of the groove is 1 / 2 of the cross-sectional diameter of the suppository; the length of the groove is 1 / 2 of the length of the suppository body 3 / 5; the bottom of the groove is an arc protruding downward.

Embodiment 2

[0048] A split suppository, which includes a split suppository comprising a grooved suppository and a tampon separated from the suppository; the suppository is mainly composed of tinidazole, semi-synthetic fatty acid glycerides, tallow fat and xylitol The mixture of anhydride monostearate; the groove is composed of the side wall of the groove and the bottom of the groove; the cross-sectional diameter of the groove is 1 / 3 of the cross-sectional diameter of the suppository; the length of the groove is 1 / 3 of the length of the suppository 1 / 5; the bottom of the groove is arc-shaped protruding downward; the opposite position of the side wall of the groove is provided with a dimple which is sunken into the bolt body, and the shape of the dimple is arc-shaped.

Embodiment 3

[0050] A split type suppository, which includes a split type suppository including a plug body with grooves and a tampon separated from the plug body; the plug body is mainly composed of ketoconazole and semi-synthetic fatty acid glycerides, tallow fat and xylitol The mixture of anhydride monostearate; the groove is composed of the groove side wall and the groove bottom; the cross-sectional diameter of the groove is 2 / 3 of the cross-sectional diameter of the suppository; the length of the groove is the length of the plug body 4 / 5; the bottom of the groove is arc-shaped protruding downward; the opposite position of the side wall of the groove is provided with a dimple that is sunken into the plug body, and the shape of the dimple is arc-shaped; the side wall of the groove is covered with a film layer , the film layer is composed of 6 parts by weight of polyvinyl acetate, 0.7 parts of chitin, 2 parts of isopropyl myristate and 0.2 parts of colloidal silicon dioxide.

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Abstract

The invention relates to a split type suppository as well as a preparation method and a use thereof. The split type suppository comprises a suppository body with a groove and an expansion carrier which is mutually separated from the suppository body, wherein the suppository body mainly comprises active ingredients and a matrix; the groove is composed of a groove side wall and a groove bottom; the diameter of the cross section of the groove is 1 / 3-2 / 3 that of the cross section of the suppository body; and the length of the groove is 1 / 5-4 / 5 the length of the suppository body. The split type suppository provided by the invention not only can avoid the examination and approval of the drug administration agencies, but also can refrain the expansion carrier from adsorbing the active ingredients and the matrix in the suppository body due to splitting of the suppository body and the expansion carrier.

Description

technical field [0001] The invention belongs to the field of preparations, in particular to a split suppository and its preparation method and application. Background technique [0002] Gynecological diseases are a general term for female reproductive system diseases. Common gynecological diseases mainly include cervicitis, vaginitis, pelvic inflammatory disease, endometritis, etc. Gynecological diseases are common and frequently-occurring diseases in women, which have always troubled many women. At present, one of the most effective methods for treating gynecological diseases is to make suppositories of active ingredients and bases and insert them into the vagina of patients, which can directly act on the vagina without side effects such as the first-pass effect of oral preparations, and the curative effect is remarkable. [0003] The applicant has conducted a lot of research on suppositories, and has developed a variety of vaginal expansion suppositories. In the preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K47/14A61K47/36A61P15/02A61P15/00
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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