29 results about "Suppository Dosage Form" patented technology

The invention discloses an indole compound with an effect of treating idiopathic pulmonary fibrosis as well as a preparation method and application of the indole compound, belongs to the field of medicinal chemistry, and particularly relates to an indole compound shown in a general formula I or pharmaceutically acceptable salt of the indole compound and application of the indole compound serving as an HDAC6 inhibitor in the aspect of resisting idiopathic pulmonary fibrosis. The invention also relates to a pharmaceutical composition taking the indole compound or the pharmaceutically acceptable salt thereof as an active ingredient. The invention also relates to an administration dosage form of the compound containing at least one compound or salt thereof, wherein the dosage form is selected from one or more of the following dosage forms: tablets, capsules, injections, suppositories, patches, inhalable powder preparations, suspensions, emulsions or ointments. The invention provides a new thought for exploring medicines capable of effectively treating idiopathic pulmonary fibrosis, and has important clinical significance. # imgabs0 #

The invention discloses a Chinese patent medicine for treating gynecological inflammatory diseases, and particularly discloses a pelvic inflammation temperature-sensitive suppository as well as a preparation method and a drug delivery device.The pelvic inflammation temperature-sensitive suppository is prepared from the following raw materials in parts by weight: 30-60 parts of polygonum cuspidatum, 30-40 parts of sargentgloryvine stem, 20-30 parts of radix isatidis, 20-30 parts of honeysuckle, 20-30 parts of golden cypress, 20-30 parts of patrinia, 30-40 parts of salvia miltiorrhiza, 20-30 parts of ligusticum wallichii, 20-30 parts of corydalis tuber, 20-30 parts of achyranthes bidentata and 20-30 parts of rhizoma cyperi. 20-30 parts of selfheal and 10-20 parts of liquorice. The dosing device is arranged, through autolysis of medicine, the medicine stored in the medicine storage cavity breaks through the diaphragm and enters the water storage cavity, the medicine and water are mixed to form mixed liquid, then the mixed liquid enters the rectum focus of a patient and is absorbed through the temperature of the human body, positioning type dosing is achieved, the dosing precision is high, and the dosing effect is good. And adverse factors such as intestinal wall stimulation and obvious foreign body sensation caused by enema and various suppositories are avoided, and the formula raw materials and the proportion of all components are optimized, so that a better treatment effect is achieved.

The invention relates to a medicine for endometrial cell senescence and a preparation process thereof, and belongs to the technical field of traditional Chinese medicine preparations. The medicine comprises the following traditional Chinese medicine components: 10-30 parts of semen cuscutae, 5-15 parts of herba taxilli, 5-15 parts of radix dipsaci, 5-15 parts of radix angelicae sinensis, 5-15 parts of radix scutellariae, 5-15 parts of radix paeoniae alba, 5-15 parts of rhizoma chuanxiong and 1-9 parts of rhizoma atractylodis macrocephalae, and has a remarkable curative effect on endometrial cell senescence in the implantation window phase of recurrent abortion. Pharmacodynamic experiments prove that the suppository prepared from the traditional Chinese medicine disclosed by the invention can be used for remarkably improving endometrial cell senescence, especially endometrial cell senescence in an implantation window stage (WOI) of recurrent abortion (URSA). The dosage form of the medicine can be suppositories, granules, capsules and the like, pharmacodynamic experiments prove that the same technical effect can be achieved, and the preparation is simple in preparation technology and suitable for further popularization and application.

The utility model belongs to the technical field of cooling devices, and particularly relates to a cooling device for suppository preparation, which comprises a base, four universal wheels which are uniformly distributed are arranged at the lower end of the base, a supporting mechanism is arranged on the base, a cooling-water machine main body is arranged at the upper end of the base, damping plates are arranged at two ends of the cooling-water machine main body, and the damping plates are arranged at two ends of the cooling-water machine main body. A waste heat recoverer is arranged on the top of the cooling-water machine body, and the middle of the upper end of the cooling-water machine body is fixedly sleeved with a water pumping pipe. Through the arrangement of the first motor, the circulating air cooler, the ventilation pipe, the stirring rod and other structures, cold air can pass through the ventilation pipe by starting the circulating air cooler, water in the water storage tank can be cooled through the ventilation pipe, the stirring rod can be driven to rotate by starting the second motor, and the cooling efficiency can be improved through rotation of the stirring rod; and by arranging the water cooling mechanism, the use efficiency of the cooling device for suppository preparation is improved.

The invention relates to the technical field of medicine, and discloses a leech preparation for improving sleep disorder and a preparation method and application of the leech preparation. The leech extract is selected from one or more of leech, leech, leech, whitmania pigra, whitmania pigra, hirudo nipponia, whitmania pinnata, poecilobdella manillensis, whitmania lubrida and whitmania occulta; the preparation can be prepared into tablets, capsules, granules, injections, ointments, suppositories, aerosols, sprays or traditional Chinese medicine preparations. The preparation method comprises the following steps: chopping leeches, soaking, performing reflux extraction, concentrating an extracting solution into clear paste, further purifying through alcohol precipitation, and mixing the purified extract with auxiliary materials to prepare a target dosage form. According to the leech preparation, by adjusting neurotransmitter balance, resisting inflammation and oxidation and improving brain microcirculation, the sleep latency can be remarkably shortened, the sleep duration can be prolonged, and sleep disorders can be effectively improved.

The present invention belongs to the technical field of medical devices, and in particular relates to a suppository administration device. It includes a sleeve, in which a control mechanism is inserted and fixedly connected to the control mechanism. A push rod is slidably connected to the control mechanism. A reverse drive mechanism is also provided in the sleeve. The reverse drive mechanism and the push rod are connected through a transmission element. A flap-type protective cover is also connected to the sleeve. The advantages are as follows: By controlling the reverse drive mechanism through the control mechanism, the reverse drive mechanism drives the push rod to move towards the head direction of the suppository administration device, thereby pushing the suppository, and the suppository is completely pushed out, thus completing the administration. A patient can complete the operation with one hand, and the operation is simple and convenient to use.

The utility model discloses a reusable suppository pusher, which comprises a main shell, a detachable tube head and a suppository medicinal plastic clamp, the inside of the main shell is connected with a first medicine pushing tube in a sliding manner, the outer side wall of the first medicine pushing tube is provided with scale marks, and the first medicine pushing tube is sleeved with a pushing depth adjusting component. The first medicine pushing pipe and the like are installed, so that the structure of the device is optimized, and a user can utilize a clamping connection structure between the assembling insertion strip and the first medicine pushing pipe to assemble the medicine pushing pipe. Therefore, parts, extending into the body of a patient, of the device can be directly detached and replaced through the detachable pipe head, it is guaranteed that the parts extending into the body of the patient can be used in a disposable mode with high safety, other parts of the device can be reserved and can be repeatedly used, the risk of cross infection is avoided through the structure, and the safety of the device is improved. And resource waste caused by one-time use of all the structures can be avoided, and popularization is facilitated.

The utility model belongs to the technical field of filling equipment, and particularly relates to a medicine filling device based on a suppository lever principle. Comprising a rack, a material clamping device and a filling device are arranged on the rack, a pump body is provided with a main feeding channel and a plurality of filling channels, and a material suction cavity communicates with the main feeding channel through an injection cavity; the material suction piston assembly comprises a plurality of filling piston rods movably arranged in the corresponding material suction cavities, and the filling piston rods are driven by a first driving device; the injection assembly comprises a plurality of injection rods movably arranged in the corresponding injection cavities, feeding grooves are formed in the outer walls of the injection rods, and during material suction, the material suction cavities communicate with the main feeding channel through the feeding grooves; an injection channel is formed in the injection rod, and the material suction cavity communicates with the injection head through the injection channel during material injection; and the injection rod is driven by a second driving device. The suppository injector has the characteristics of simple structure, convenience in charging metering adjustment, high suppository injection precision, good sealing performance, high working efficiency, long service life and the like.

A pharmaceutical composition and methods for using the pharmaceutical composition are disclosed. The pharmaceutical composition may include a therapeutically effective amount of one or more antiviral active pharmaceutical ingredients and a pharmaceutically acceptable excipient. The pharmaceutical composition may be a solid dosage form, wherein the solid dosage form provides sustained release of the antiviral active pharmaceutical ingredient when administered as a vaginal or rectal insert.

The invention relates to the technical field of medical instruments, in particular to a suppository shaping and boosting integrated device which comprises a main body assembly, a boosting shell is included, a containing cavity and a containing groove are formed in the boosting shell, a guide pipe and a mold are arranged in the containing cavity, and cooling fins and a reset structure are further arranged on the outer wall of the mold; a pushing structure is further arranged in the containing cavity and comprises a screw rod, a piston piece is arranged at the end of the screw rod, and the piston piece extends into the guide pipe and is used for pushing the paste; the screw rod is driven by a single power source, and the screw pitch difference design of the spiral groove and the moving column is matched, so that the movable sleeve quickly moves in the early stage to drive the supporting plate to be accurately in place, synchronously and slowly moves with the screw rod in the later stage to complete pushing and adapt to the time rhythm of paste cooling and shaping, and the working efficiency is greatly improved; separation and reset of the mold depend on sliding fit of a wire groove and a guide column and multi-component linkage of a reset structure, separation is stable, reset is accurate, paste microcoagulation is rapidly achieved in cooperation with a cooling fin, and suppository shaping consistency and integrity are guaranteed.

The present application relates to a polypeptide LLLE derived from sturgeon cartilage and its application, in particular to a polypeptide LLLE derived from sturgeon cartilage and its application in improving obesity caused by food pesticide residues. The sequence of the polypeptide LLLE is: Leu-Leu-Leu-Glu; based on it, various pharmaceutically acceptable dosage forms can be prepared, including but not limited to injection, tablet, capsule, pill, granule, syrup and other oral liquid, suppository; it can effectively alleviate fat accumulation and blood lipid abnormality caused by chlorpyrifos chronic exposure and high-fat diet, that is, control obesity caused by chlorpyrifos chronic exposure, significantly reduce the content of serum total glyceride, total cholesterol and low-density lipoprotein cholesterol, improve the content of serum high-density lipoprotein cholesterol and regulate blood lipid. Moreover, the food-derived oligopeptide is stable and easy to absorb, safe and environmentally friendly, and has no toxic and harmful effects on human body.

Formulations comprising hydrocortisone are disclosed in a suppository for methods of treating ulcerative colitis and other gastrointestinal diseases and disorders. Administering a single hydrocortisone suppository once a day achieves remission or reduction of a symptom, optionally followed by a period of time in which the dosage is reduced.

A natural orifice synergistic drug delivery device comprises a slender hard rod-shaped body (11) and a soft body (12) wrapping the rod-shaped body (11), the rod-shaped body (11) is provided with a rod-shaped body head part (111) entering a natural orifice opening during use, a rod-shaped body middle part (112) and a rod-shaped body tail part (113) located outside the natural orifice opening during use, and the drug delivery device (1) is provided with a liquid injection port (101), a liquid passage (10) and a radial liquid outlet (102). The head area of the soft body (12) is provided with a hollow flexible wrapping part (125) and / or a suction cup part (127), the internal space (1250) of the flexible wrapping part can at least contain a part of the tail part (23) of the solid suppository, and during use, the solid suppository (2) is firstly inserted into the flexible wrapping part (125) and / or adsorbed on the suction cup part (127), and then the administration device is slowly inserted into a natural orifice through an opening of the natural orifice. And then a liquid medicament is injected through the liquid injection port, the dosing device is pulled out of the opening of the natural cavity, and the solid suppository is retained in the natural cavity.

The invention relates to the field of pharmaceutics and medicine, namely, to a new dosage form of cortexin, rectal suppositories, capable of normalizing brain functions and characterized by efficacy and safety comparable to an injectable form. The invention also relates to a rectal cortexin composition in a suppository form, the composition comprising cortexin in a pharmacologically effective amount and a suppository base.

The utility model relates to the technical field of medical instruments, in particular to an anorectal suppository dosing device. Comprising an administration end provided with a plurality of separable side walls, a medicine carrying cylinder, a push rod used for pushing suppositories in the medicine carrying cylinder, and a buffer component used for reducing the pushing speed of the push rod. The inner wall of the separable side wall is provided with a lubricating bag for wrapping a lubricating agent, and the separable side wall is provided with a hole for the lubricating agent to seep; according to the utility model, the lubricating bag and the hole are arranged, so that a lubricating agent can uniformly seep from the hole after being extruded, the lubricating agent is prevented from being smeared by hands before administration, and the lubricating operation is simple, rapid, clean and sanitary; by arranging the buffer component, the push rod pushing speed is controllable, the push rod can be pulled back easily, self-administration of a patient can be achieved easily, privacy of the patient can be protected, pain of the patient can be relieved, and the treatment enthusiasm of the patient for using the anorectal suppository is improved.

The utility model discloses a painless bolt pushing device used after anorectal operation, which relates to the technical field of medical instruments and comprises a painless bolt pushing device shell, a push rod is arranged in the painless bolt pushing device shell, a piston is fixedly mounted at the bottom of the push rod, a handle is fixedly mounted at the top of the push rod, and a handle is fixedly mounted at the bottom of the handle. An auxiliary extension is fixedly installed on the upper portion of the outer surface of the painless bolt pushing device shell, a lining is fixedly installed in the painless bolt pushing device shell, a suppository customized to be particularly long and thin is placed in the lining, and a thin film is arranged at the bottom of the painless bolt pushing device shell. The outer surface of the shell of the painless suppository pusher is subjected to super-smooth treatment, the suppository customized to be particularly slender is placed in the lining, the painless suppository pusher can be used for rectal administration after an anorectal small operation similar to haemorrhoids, and the problems that due to the fact that fingers are too thick, the suppository is slippery when a haemorrhoids suppository is plugged, and the suppository is not prone to being plugged by a patient repeatedly are solved.

The invention relates to a suppository vacuum emulsification system, and relates to the technical field of suppository processing, the suppository vacuum emulsification system comprises a base table and a processing table, the base table is vertically provided with a first premixing tank and a second premixing tank, and the lower parts of the first premixing tank and the second premixing tank are respectively provided with a first output pipe and a second output pipe; a configuration tank main body is vertically mounted on the treatment table; the other end of the first output pipe and the other end of the second output pipe are communicated with the upper part of the configuration tank main body, the bottom of the configuration tank main body is connected with a discharging pipe, and a temperature control assembly for controlling the temperature of the configuration tank main body and a protective cover mounted outside the temperature control assembly are arranged above the treatment table. The first output pipe, the second output pipe and the discharging pipe are each sleeved with a heat preservation pipe. According to the device, the first output pipe, the second output pipe and the discharging pipe are all sleeved with the heat preservation pipes, and by means of the design, the temperature stability of materials in the feeding, discharging and configuration processes can be effectively maintained.

The utility model belongs to the technical field of suppository liquid medicine production devices, and particularly relates to a suppository liquid medicine filtering device which comprises a cavity, a rotating mechanism is arranged on the outer wall of the cavity and comprises a motor frame, the top of the motor frame is fixedly connected with a motor, the output end of the motor is fixedly connected with a main gear, and the main gear is located in the motor frame. The top of the main gear is movably connected with the top of the inner wall of the motor frame, a linkage gear is installed in the motor frame, the bottom of the linkage gear is movably connected with the bottom of the inner wall of the motor frame, a connecting rod is fixedly connected to the upper surface of the linkage gear, a supporting plate is fixedly connected to the top of the connecting rod, and a locking mechanism is arranged at the top of the supporting plate. The locking mechanism comprises an air pump, and the bottom of the air pump is fixedly connected with the top of the supporting plate. The whole locking mechanism can rotate while the cover plate and the top of the cavity are opened and closed through cooperation of the motor and the air pump, the filter screen can be taken out conveniently, manual operation is not needed in the whole process, and therefore production efficiency is improved.

Suppository compositions are provided combining a pharmaceutically acceptable matrix material that is solid outside of the human body and in a dry environment, but which melts at body temperature; and apple cider vinegar and one or more species of probiotic bacteria dispersed within the matrix material; wherein the matrix material contains a mixture of fatty acids that are solid at room temperature. Methods for supplementing and nourishing the microbiome of the rectum of a male or female and the microbiome of the vagina of a female are also disclosed. Oral dosage forms of the compositions of the present invention are also provided.

The invention discloses a shaping device for suppository preparation and a using method, and relates to the technical field of suppository preparation.The shaping device comprises a mounting frame, a lower mold is fixedly connected to the bottom end of the inner side of the mounting frame, an upper mold is arranged on the upper portion of the lower mold, and a circulating water tank is fixedly connected to the upper end of the mounting frame; a water circulating unit is arranged on the rear side of the circulating water tank, a downward pressing unit is fixedly connected to the upper end of the inner side of the mounting frame, connecting units are fixedly arranged at the four corners of the bottom of the downward pressing unit, and the bottom of the water circulating unit is arranged on the inner side of the lower mold. The water circulation unit realizes uniform cooling, can stably control the circulating water temperature, prevents the temperature difference of different areas of the mold caused by water temperature fluctuation, enables suppositories at all positions in the mold to be solidified in a uniform cooling environment, reduces the defects of surface cracking and uneven hardness, and guarantees the quality consistency of the suppositories in the same batch.

The utility model belongs to the technical field of suppository preparation, and particularly relates to a shaping device for suppository preparation, which comprises a main body component, the main body component comprises a rack, a heating box is rotatably connected in the rack, a demoulding component is arranged at the bottom of the heating box, the demoulding component comprises a connecting plate, and the top of the connecting plate is fixedly connected with the bottom of the heating box. A cavity plate is fixedly connected to the bottom of the connecting plate, an L-shaped rod is rotationally connected into the cavity plate, a supporting plate is fixedly connected to the side wall of the cavity plate, a telescopic rod is rotationally connected to the bottom of the supporting plate, the top of the telescopic rod is rotationally connected with the bottom of the L-shaped rod, and a spring is installed on the outer wall of the telescopic rod. Two ends of the spring are fixedly connected with two ends of the telescopic rod respectively. According to the suppository demolding device, the demolding component is arranged, so that the output end of the second motor can drive the rubber block to continuously knock the heating box, suppositories in a mold can fall into the collecting box due to impact force generated by knocking, and the suppository demolding efficiency is improved.

A composition for increasing sexual pleasure in an adult human includes: a dosage form selected from capsules, tablets, oral drops, infused edibles, infused food preparations, infused drink preparations, massage oils, lotions, gels, creams, lubricants, patches, and suppositories, the dosage form containing: a quantity of a PDE5 inhibitor that is no greater than 50% of a full prescription quantity or dose of the PDE5 inhibitor for an adult male; and a quantity of a cannabinoid component sufficient to amplify the effect of the PDE5 inhibitor to at least 80% of the effect of the full prescription quantity or dose for an adult male, wherein the PDE5 inhibitor and the cannabinoid component are effective in increasing sexual pleasure in the adult human in need thereof, including at least one of increased blood flow to erectile tissue, increased sexual desire, increased sexual arousal, increased sexual sensitivity, or increased strength of orgasm.

Formulations comprising hydrocortisone are disclosed in a suppository for methods of treating ulcerative colitis and other gastrointestinal diseases and disorders. Administering a single hydrocortisone suppository once a day achieves remission or reduction of a symptom, optionally followed by a period of time in which the dosage is reduced.

1. The name of the design product: a dosing device. 2. The use of the design product: for pushing a suppository into a patient's vagina. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 2.

The invention provides an enema nano suspension system for treating ulcerative colitis, which is prepared by taking indigo blue and indirubin as active components, adding a space stabilizer and a potential stabilizer and adopting a wet medium grinding method. The invention also provides an enema nano-foam system for treating ulcerative colitis. The enema nano-foam system comprises the drug-containing foam base liquid and the propellant. Aiming at the problems of poor solubility and permeability of indigo blue and indirubin, auxiliary materials are combined with a ball milling technology, and indigo blue and indirubin are subjected to surface modification and nanocrystallization, so that the solubility and permeability of indigo blue and indirubin are improved, the absorption of inflammatory cells to drugs is enhanced, and the bioavailability of indigo blue and indirubin is improved. The problems that conventional dosage forms such as traditional Chinese medicine rectal administration enema liquid and suppositories are prone to leakage, strong in foreign body sensation, limited in medicine distribution area and difficult to reach deeper ulcer lesions in intestines are solved, and the vacancy that at present, no convenient and effective enema treatment is available for ulcerative colitis is made up.

The utility model relates to the technical field of suppository medicine, in particular to boxed suppository medicine conveying equipment which comprises a shell, a bearing assembly and a cooling assembly, a conveying belt is arranged in the shell, the bearing assembly is arranged on the outer surface of the conveying belt, a positioning assembly is arranged at the top in the shell, and the cooling assembly is arranged in the shell. A cooling assembly is arranged at the top of the shell; the bearing assembly comprises a material receiving plate, grooves are formed in the surfaces of the two sides of the material receiving plate, supporting plates are rotationally connected into the grooves, rotating shafts are connected to the tops and the bottoms of the supporting plates through bolts, and the supporting plates are rotationally connected with the grooves through the rotating shafts. By additionally arranging the auxiliary bearing material supporting mechanism, the stability of the medicine in the conveying process is improved in the modes of overturning, positioning, buffering and supporting, and therefore the using effect is improved.

The present invention belongs to the field of medicinal chemistry, and particularly relates to indole derivatives represented by general formula I, and their optically active forms or racemates, diastereoisomer mixtures, and the use of such compounds as SIRT2 inhibitors and their application in anti-pancreatic cancer metastasis. The present invention also relates to pharmaceutical compositions containing such compounds and their pharmaceutically acceptable salts as active ingredients. The present invention also relates to pharmaceutical dosage forms of such compounds containing at least one such compound or its salt, and the dosage forms are selected from one or more of the following: tablets, capsules, injections, suppositories, patches, inhalable powder preparations, suspensions, emulsions or ointments.

Formulations comprising hydrocortisone are disclosed in a suppository for methods of treating ulcerative colitis and other gastrointestinal diseases and disorders. Administering a single hydrocortisone suppository once a day achieves remission or reduction of a symptom, optionally followed by a period of time in which the dosage is reduced.

The utility model relates to a suppository package, and belongs to the technical field of medicaments. Comprising a first packaging piece and a second packaging piece, parts of the first packaging piece and the second packaging piece are oppositely attached, and the first packaging piece and the second packaging piece are bonded together in a sealed mode, and a medicine storage cavity used for containing a stype is formed in a bonding area between the first packaging piece and the second packaging piece. A first tearing area is arranged at the tail section of the side, close to the stype head, of the first packaging piece, and a second tearing area is arranged at the tail section of the second packaging piece and staggered with the first tearing area. In the length direction of the medicine storage cavity, bonding areas with different bonding strengths are arranged on the first packaging piece and the second packaging piece, so that the suppository is prevented from being completely opened when being opened; the technical problems that in the prior art, suppository packages are difficult to open, the packages are suddenly and completely opened during opening, suppositories fall on the ground, and follow-up safe and sanitary use of the suppositories is affected are solved.