The invention relates to a controlled-release colon targeting
drug adminitration preparation. The forms of the preparation are colon site-specific
coated tablets or colon targeting
pellets. The preparation consists of a tablet core or pellet core, an isolating layer and a controlled-release
coating layer, wherein the controlled-release
coating layer comprises an internal
coating layer and an external coating layer. By adopting the multilayer coating technology, enteric soluble
acrylic resin water dispersion and osmotic
acrylic resin water dispersion are used as main
coating materials for carrying out coating, thereby obtaining the controlled-release colon targeting
drug adminitration preparation. The preparation of the invention enables drugs to be released at a
constant rate at a colon section, realizes accurate site-specific
drug release, increases the concentration of the drugs at some parts of positions with
pathological changes, is beneficial to treating
ulcerative colitis and
carcinoma of colon, avoids the stimulation of the drugs on stomaches and small intestines, achieves the goal of colon site-specific
drug release, enhances the targeting site-specific
curative effect on colon diseases and reduces the toxic and
side effect. Compared with the common oral preparations, under the condition of the same drug adminitration dosage, the preparation of the invention can enhance the
curative effect and reduce the incidence rate of untoward reactions. Compared with the enemas or the rectal suppositories, the preparation has the advantages of uniform drug distribution in the colon and good
patient compliance.