Lincomycin Sustained Release Granules

A technology of lincomycin and sustained-release granules, which is applied in the direction of block delivery, digestive system, antibacterial drugs, etc., and can solve the problems of reducing the number of times of taking medicine, low bioavailability, and inconvenient taking

Active Publication Date: 2016-08-31
邳州舜邦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the disadvantages of inconvenient taking and low bioavailability of the existing lincomycin preparations, the present invention invented lincomycin inclusion compound slow-release granules, which can reduce the number of times of taking medicine, slow down the absorption rate, prolong the biological half-life, and make the blood medicine The concentration is controlled within the effective blood concentration range, thereby reducing side effects and improving patient compliance

Method used

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  • Lincomycin Sustained Release Granules
  • Lincomycin Sustained Release Granules
  • Lincomycin Sustained Release Granules

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of lincomycin inclusion compound includes:

[0025] (1) React lincomycin with γ-cyclodextrin in a water or water-containing ethanol medium in a certain proportion, filter the resulting solution through a microporous membrane until it is clear, and separate the clathrate from the mixture; or

[0026] (2) React lincomycin with γ-cyclodextrin in solid form; or

[0027] (3) Lincomycin reacts with γ-cyclodextrin for high-energy grinding.

[0028] The measurements in the present invention are all weights.

[0029] The prescription of the lincomycin sustained-release granules of the present invention is (by weight):

[0030] Lincomycin Inclusion Compound

Embodiment 1

[0031] Example 1 prescription

[0032] Lincomycin inclusion compound: Lincomycin: γ-cyclodextrin is 2:3.5

[0033] Lincomycin Inclusion Compound

50 servings

Lactose

190 copies

Magnesium stearate

4 parts

Saccharin Sodium

4 parts

Hypromellose

70 servings

Glyceryl Monostearate

30 servings

Polyvinyl chloride

85 servings

[0034] Preparation:

[0035] 1. Prepare the lincomycin inclusion compound according to the following method:

[0036] (1) React lincomycin with γ-cyclodextrin in a water or water-containing ethanol medium in a certain proportion, filter the resulting solution through a microporous membrane until it is clear, and separate the clathrate from the mixture; or

[0037] (2) React lincomycin with γ-cyclodextrin in solid form; or

[0038] (3) Lincomycin reacts with γ-cyclodextrin for high-energy grinding.

[0039] 2. Crush the lincomycin inclusion compound through a 100-mesh sieve, and pulverize the remaining auxiliary materials through an 80-mesh sieve; ac...

Embodiment 2

[0041] The lincomycin and γ-cyclodextrin described in Example 1 were fully ground in 50% ethanol to form a uniform paste. After vacuum drying, a white powder was obtained. The solubility of the powder in water is better than that of the unincluded Linco The mycin increased 17 times.

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Abstract

The invention relates to controlled-release lincomycin granules. Firstly, tamoxifen citrate is prepared into a clathrate compound and then the clathrate compound is prepared into the controlled-release granules.

Description

Technical field [0001] The application relates to a sustained-release granule, specifically, a lincomycin inclusion compound sustained-release granule. Background technique [0002] Lincomycin, the English name Lincomycin. Acts on the 50S subunit of the ribosome of sensitive bacteria to prevent the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Chemical name: 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-6,8-dideoxy-D-erythro-α-D- Galactopyranoside hydrochloride monohydrate. Lincomycin is a white crystalline powder; slightly odor or special odor; bitter taste. Lincomycin is soluble in water or methanol, but slightly soluble in ethanol. Lincomycin acts on the 50S subunit of the ribosome of sensitive bacteria to prevent the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Lincomycin is generally a bacteriostatic agent, but at high concentrations, it also has a bactericidal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/7056A61P31/04A61P11/00A61P19/08A61P19/02A61P17/00A61P1/16
Inventor 李淑兰
Owner 邳州舜邦生物科技有限公司
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