Diabetes diagnosis and risk stratification using mr‑proadm

A technology of diabetes and diabetes, which is applied in the field of diabetes, can solve the problem that the suitability of diabetes diagnosis is not disclosed, and achieve the effect of rapid diagnosis

Active Publication Date: 2018-01-30
BRAHMS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the suitability of central region proadrenomedullin (MR-proADM:SEQ ID No.2) for the diagnosis of diabetes has not been published

Method used

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  • Diabetes diagnosis and risk stratification using mr‑proadm
  • Diabetes diagnosis and risk stratification using mr‑proadm
  • Diabetes diagnosis and risk stratification using mr‑proadm

Examples

Experimental program
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Embodiment 1

[0033] The MR-proADM test was performed as described by Morgenthaler et al. (Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin in plasma with immunoluminometric assay. Clin Chem. 2005 Oct;51(10):1823-9).

[0034] MR-proADM was tested in 100 healthy subjects with undisturbed glucose tolerance, 60 patients with disturbed glucose tolerance and 200 patients with overt type II diabetes (abbreviated as "DM II"). These 200 patients were divided into 100 diabetic patients who did not suffer from any secondary diseases, and 100 diabetic patients who had already suffered from secondary diseases such as diabetic nephropathy and diabetic retinopathy.

[0035] image 3 show. MR-proADM values ​​increased significantly with increasing severity of DM II. Two groups of DM II patients differed especially from healthy controls and patients with impaired glucose tolerance. Surprisingly, the highest MR-proADM values ​​were found in DM II patients who ...

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Abstract

The present invention relates to diabetes diagnosis and risk stratification using MR‑proADM. In particular, the present invention relates to a method for the diagnosis and / or risk stratification of diabetes mellitus, especially secondary diabetes mellitus, wherein the marker central region proadrenomedullin (MR‑proADM: SEQ ID No. 2 ) or partial peptides or fragments thereof, or if it is included in a marker combination (marker set, marker cluster). Furthermore, the invention relates to diagnostic devices and kits for carrying out said methods.

Description

[0001] This application is a divisional application of the invention patent application with the application number 200780041709.4, the application date is November 8, 2007, and the invention title is "diabetes diagnosis and risk classification using MR-proADM". technical field [0002] The present invention relates to a method for diagnosis and / or risk stratification of diabetes mellitus, in particular secondary diseases of diabetes mellitus, wherein the marker central region proadrenomedullin (midregional proadrenomedullin, MR-proADM:SEQ ID No.2) is carried out in the patient to be studied The determination of its partial peptides or fragments, or the determination of being included in a marker combination (marker group, marker cluster). Furthermore, the invention relates to diagnostic devices and kits for carrying out said methods. Background technique [0003] The diagnosis of diabetes is well known with adrenomedullin (Garcia-Unzueta MT, Montalban C, Pesquera C, Berrazu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N33/74
CPCG01N33/6893G01N33/74G01N2800/042
Inventor A·博格曼N·莫根塔勒J·帕帕索提里奥J·斯塔克
Owner BRAHMS GMBH
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