Method for extracting hyoscyamine from mandragora flower
A technology of datura flower and scopolamine, which is applied in the direction of organic chemistry and the like, can solve the problems of large amount of solvent, long extraction time, low extraction rate and the like, and achieves the effects of low production cost, improved extraction rate and improved solubility
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[0016] Example 1
[0017] Add 1000g of Datura flower to 1 times 70% ethanol solution, pulverize with plant tissue crushing extraction method for 2 minutes, take it out, add 8 times 70% ethanol, adjust the pH to 4.5 with hydrochloric acid, and place it under ultrasound Extract in the extractor for 30 minutes, the ultrasonic power is 600W, the extract is centrifuged, the supernatant is added to the HZ-818 macroporous resin column for adsorption, the resin column is washed with water, and then 8 times the ammonia-containing 5% ammonia ethanol solution is added for elution For the active ingredients, the eluate is collected, concentrated to obtain the total alkaloids, and ethanol is recrystallized twice to obtain scopolamine with a content of 85.4%.
Example Embodiment
[0018] Example 2
[0019] Add 1000g of Datura flower to 3 times 75% ethanol solution, pulverize with plant tissue crushing extraction method for 1.5min, take it out, add 10 times 75% ethanol, adjust the pH to 5.0 with hydrochloric acid, and place Extract in an ultrasonic extractor for 40 minutes, the ultrasonic power is 800W, the extract is centrifuged, the supernatant is added to the D-72 macroporous resin column for adsorption, the resin column is washed with water, and then 10 times the ammonia ethanol solution with 7% ammonia is added. The effective components are removed, the eluate is collected, concentrated to obtain total alkaloids, and ethanol is recrystallized twice to obtain scopolamine with a content of 88.1%.
Example Embodiment
[0020] Example 3
[0021] Add 1000g of Datura flower to 2 times 80% ethanol solution, pulverize with plant tissue crushing extraction method for 1 min, take it out, add 9 times 80% ethanol, adjust the PH value of acetic acid to 5.5, and place it under ultrasound Extract in the extractor for 50 minutes, the ultrasonic power is 1000W, the extract is centrifuged, the supernatant is added to the D-101 macroporous resin column for adsorption, the resin column is washed with water, and then 9 times the ammonia-containing 10% ammonia ethanol solution is added for elution The active ingredients are collected and the eluate is concentrated to obtain total alkaloids, and ethanol is recrystallized twice to obtain scopolamine with a content of 86.5%.
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