A device for adsorption and separation of human prothrombin complex

A human prothrombin, adsorption separation technology, applied in the field of biochemical industry and biopharmaceuticals, can solve the problems of no separation function, high price, only adsorption function, etc., to achieve the effect of prolonging the operation time, low cost, and avoiding pollution

Active Publication Date: 2016-08-24
成都英德生物医药装备技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to solve the problem that the existing adsorption tank has only adsorption function but no separation function in the production of PCC, and the use of an expanded bed for PCC adsorption and separation requires the use of special adsorption media and is expensive. It provides a human prothrombin complex adsorp...

Method used

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  • A device for adsorption and separation of human prothrombin complex
  • A device for adsorption and separation of human prothrombin complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] An adsorption and separation device for human prothrombin complex, comprising a tank body 1 and a stirring part, the tank body 1 is provided with a buffer distribution pipe 2 and a feed pipe 3, the buffer distribution pipe 2 and the The feed pipe 3 extends from the top of the tank 1 to the inside of the tank 1, and the top of the tank 1 is also provided with a manhole 4; the bottom of the tank 1 is provided with an openable The tank bottom plate 5 is provided with a filter plate 6 on the top of the tank bottom plate 5, and a tank bottom valve 7 is provided at the bottom of the tank bottom plate 5.

[0029] The above-mentioned human prothrombin complex adsorption and separation device is the basic technical solution of the present invention. in:

[0030] The filter plate 6 of the present invention can be a multi-layer weaving or firing filter plate, nylon cloth, etc., and the material can be stainless steel or plastic, and the filter plate is 100 mesh to 400 mesh.

[0...

Embodiment 2

[0033] An adsorption and separation device for human prothrombin complex, comprising a tank body 1 and a stirring part, the tank body 1 is provided with a buffer distribution pipe 2 and a feed pipe 3, the buffer distribution pipe 2 and the The feed pipe 3 extends from the top of the tank 1 to the inside of the tank 1, and the top of the tank 1 is also provided with a manhole 4; the bottom of the tank 1 is provided with an openable The tank bottom plate 5 is provided with a filter plate 6 on the top of the tank bottom plate 5, and a tank bottom valve 7 is provided at the bottom of the tank bottom plate 5.

[0034] The stirring component includes a motor 8, a speed reducer 9, a stirring support 10 and a shaft seal 11 arranged on the top of the tank body 1, and also includes a stirring shaft 12 and an agitator. The stirring shaft 12 Extending into the inside of the tank body 1, the agitator is fixed on the agitator shaft 12.

[0035] Preferably, the agitator is a ribbon agitator...

Embodiment 3

[0038] On the basis of embodiment 2, preferred:

[0039] The agitator includes an upper agitator 13 and a lower agitator 14, and the upper agitator 13 is a spiral ribbon agitator, a paddle agitator, a pusher agitator, a frame agitator or an anchor agitator, The lower agitator 14 is a paddle agitator, and the lower end of the lower agitator 14 is also provided with a scraper 15 .

[0040] The scraper 15 is clamped at the lower end of the lower agitator 14, and the scraper 15 is made of silica gel or polytetrafluoroethylene.

[0041] Preferably, the gap between the scraper 15 and the filter plate 6 is 1-5mm.

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Abstract

The invention relates to an adsorption and separation device for human prothrombin complex, belonging to the technical fields of biochemical industry and biopharmaceuticals. The present invention includes a tank body and a stirring part, the tank body is provided with a buffer distribution pipe and a feed pipe, and the buffer liquid distribution pipe and the feed pipe extend from the top of the tank body to Inside the tank, the top of the tank is also provided with a manhole; the bottom of the tank is provided with an openable tank bottom, the top of the tank bottom is provided with a filter plate, and the bottom of the tank bottom is A tank bottom valve is provided. The adsorption and separation device for human prothrombin complex of the present invention has comprehensively improved the adsorption tank, and realizes that the adsorption and separation of human prothrombin complex can be completed in the same device.

Description

technical field [0001] The invention relates to an adsorption separation device, more specifically, the invention relates to a human prothrombin complex adsorption separation device, which belongs to the technical fields of biochemical industry and biopharmaceuticals. Background technique [0002] Human prothrombin complex (PCC for short) is a trace protein contained in human plasma, which is clinically used to treat hemophilia B. The existing equipment for adsorption and separation of PCC mainly includes adsorption tanks and expanded beds. The adsorption tank is a batch processing equipment that can only complete the adsorption of PCC in plasma, and its separation requires another chromatographic column to complete. However, the PCC adsorption and separation can be completed in the same equipment by using the expanded bed, but the equipment for the adsorption and separation of PCC such as the expanded bed requires a special adsorption medium. At present, domestic PCC produ...

Claims

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Application Information

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IPC IPC(8): C12M1/12C12M1/02C12M1/00
CPCC12M27/02C12M37/04
Inventor 邱家山陈果李泉郑建国
Owner 成都英德生物医药装备技术有限公司
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