Porcine epidemic diarrhea inactivated vaccine and preparation method thereof

A porcine epidemic diarrhea and inactivated vaccine technology, applied in the field of porcine epidemic diarrhea inactivated vaccines and its preparation, can solve the problem of insufficient total secreted antibodies in the intestinal mucosa of susceptible animals, inability to effectively neutralize intestinal viruses, and antibody window long-term issues
CN104383528BActive Publication Date: 2016-08-24JIANGSU ACAD OF AGRI SCI
4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU ACAD OF AGRI SCI
Publication Date
2016-08-24

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

The invention provides a PED (Porcine Epedemic Diarrhea) inactivated vaccine and a preparation method thereof and relates to the field of biopharmacy. The PED inactivated vaccine comprises inactivated PEDV (Porcine Epedemic Diarrhea Virus), and is characterized in that the PED inactivated vaccine comprises 0.05-10 mg / mL Beta-glucosylceramide, 0.1-21 mg / mL monophosphoryl lipid A, 1.5-125 mg / mL muramyl dipeptide and 0.7-4.5 mg / mL Beta-glucan. According to the ingredients of the PED inactivated vaccine, Beta-glucosylceramide, monophosphoryl phosphoryl lipid A, muramyl dipeptide and Beta-glucan have the synergistic effect, the immune response of animals to antigens in the vaccine is significantly improved, the immune window phase is shortened, the antibody production duration of the animal body is obviously prolonged, the serum antibody level is improved, and the level of total intestinal mucosa secretory antibodies (the total SIgA) is improved.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of biopharmaceuticals, in particular to an inactivated porcine epidemic diarrhea vaccine and a preparation method thereof. Background technique

[0002] Porcine Epedemic Diarrhea (PED) is an acute, fecal-oral infectious disease characterized clinically by yellow-green watery diarrhea, vomiting, dehydration, and high mortality in newborn piglets.

[0003] The disease was first discovered in the United Kingdom and Belgium in the early 1970s. In 1978, the virus antigen was isolated in my country's Shanghai, Liaoning, Jilin, Heilongjiang and other places. Epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus antigen form, clinical symptoms, and epidemiology are very similar, but there is no cross-reaction between immunology and serology. Currently, the main viral diarrhea in pigs in my country is PED.

[0004] The prevalence of PED mainly occurs in winter, but in some areas, pig farms are affected all ye...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More