Circovirus egg yolk antibody oral liquid and preparation method thereof

A technology of egg yolk antibody and oral liquid, which is applied in the direction of antibodies, pharmaceutical formulas, antiviral agents, etc., can solve the problems of inconvenient use of egg yolk antibody for porcine circular disease, improve immunity and stress ability, and have high bioavailability , biological activity is not affected by the effect

Inactive Publication Date: 2015-03-04
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a porcine circovirus yolk antibody oral liquid and a preparation method thereof, which solves the problem of inconvenient use of the porcine circovirus yolk antibody for injection

Method used

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  • Circovirus egg yolk antibody oral liquid and preparation method thereof
  • Circovirus egg yolk antibody oral liquid and preparation method thereof
  • Circovirus egg yolk antibody oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A formula of porcine circovirus yolk antibody oral solution includes the following raw materials: 95 L of whole egg aqueous solution containing yolk antibody, 0.2 L of caprylic acid, 0.3 L of formaldehyde, 0.02 L of thimerosal, and 1000 units / ml of penicillin and streptomycin in the oral solution.

[0018] Its preparation method comprises the following steps:

[0019] 1) Use the commercially available inactivated porcine circovirus vaccine for booster immunization. The dose of vaccine per chicken is 2ml each time, and the immunization procedure is carried out three times at intervals of 10 days. When the antibody titer reaches 1:256, start collecting High free eggs.

[0020] 2) Sort the collected high-free eggs, sterilize with 0.2% bromogeramine, and set aside.

[0021] 3) Acidification treatment by water dilution method: Beat 2) Bugao egg-free whole eggs into the pasteurized tank for full emulsification. The emulsification time is 7 minutes, and then add the emulsifie...

Embodiment 2

[0040] A formula for porcine circovirus yolk antibody oral solution includes the following raw materials: 105 L of whole egg aqueous solution containing yolk antibody, 0.2 L of octanoic acid, 0.2 L of formaldehyde, 0.01 L of thimerosal, and 800 units / ml of penicillin and streptomycin in the oral solution.

[0041] Its preparation method comprises the following steps:

[0042] 1) Use the commercially available inactivated porcine circovirus vaccine for booster immunization. The dose of vaccine per chicken is 2ml each time, and the immunization procedure is carried out three times at intervals of 10 days. When the antibody titer reaches 1:128, start collecting High free eggs.

[0043] 2) Sort the collected high-free eggs, sterilize with 0.1% bromogeramine, and set aside.

[0044] 3) Acidification treatment by water dilution method: Beat 2) Bugao egg-free whole eggs into the pasteurized tank for full emulsification, emulsification time is 10 minutes, and then add the emulsified ...

Embodiment 3

[0063] A formula for porcine circovirus yolk antibody oral solution includes the following raw materials: 100 L of whole egg aqueous solution containing yolk antibody, 0.3 L of octanoic acid, 0.3 L of formaldehyde, 0.02 L of thimerosal, and 1000 units / ml of penicillin and streptomycin in the oral solution.

[0064] Its preparation method comprises the following steps:

[0065] 1) Use the commercially available inactivated porcine circovirus vaccine for booster immunization. The dose of vaccine per chicken is 2ml each time, and the immunization procedure is carried out three times at intervals of 10 days. When the antibody titer reaches 1:256, start collecting High free eggs.

[0066] 2) Sort the collected high-free eggs, sterilize with 0.2% bromogeramine, and set aside.

[0067] 3) Acidification treatment by water dilution method: Beat 2) Bugao egg-free whole eggs into the pasteurized tank for full emulsification, emulsification time is 8 minutes, and then add the emulsified ...

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Abstract

The invention discloses porcine a circovirus egg yolk antibody oral liquid and a preparation method thereof. The formula of the oral liquid is characterized by comprising the following raw materials in parts by volume: 95-105 parts of whole egg aqueous solution containing egg yolk antibodies, 0.2-0.3 part of caprylic acid, 0.2-0.3 part of formaldehyde and 0.01-0.02 part of thiomersal; the oral liquid further comprises mycillin, wherein the content of mycilline in the oral liquid is 800-1,000 unit/ml. During preparation, a clear egg yolk antibody oral liquid is prepared from whole hyperimmunity eggs. The egg yolk antibody oral liquid prepared by the method is less in loss in the production process, and has lots of immunologic active substances, high biological activity and no clinical side effect; meanwhile the oral liquid contains a great amount of various proteins and can reduce the adverse effects on antibodies caused by oral administration.

Description

technical field [0001] The invention belongs to the technical field of biological products for pigs, and relates to an oral solution of egg yolk antibody against porcine circosis and a preparation method thereof. Background technique [0002] Porcine circovirus, (Porcine circovirus, abbreviation: PCV) is the smallest animal virus found so far. It is known that PCV has two serotypes, namely PCV1 and PCV2. PCV2 is a pathogenic virus and it is the main pathogen of Postweaning Multisystemic Wasting Syndrome (PMWS) in weaned piglets. Pigs are highly susceptible to PCV2. Infected pigs can excrete the virus from nasal fluid, feces and other wastes, and infect pigs of different ages through oral and respiratory routes. After pregnant sows are infected with PCV2, they can be transmitted vertically through the placenta to infect piglets. [0003] Yolk antibody IgY is a kind of immunoglobulin Ig. IgY is functionally equivalent to mammalian IgG, but it is different in structure and ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61K9/08A61P31/20A61K31/7036A61K31/43
Inventor 徐进郭俊清
Owner ZHENGZHOU HOUYI PHARMA
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