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Preparation method of Houjiling oral solution

A technology for Hujiling oral liquid and oral liquid, which is applied in the field of drug preparation, can solve the problems of single dosage form of tablets and capsules, easy disintegration exceeding the limit, uneven content, etc., and achieves rapid curative effect, improved taste, and bioavailability. high effect

Inactive Publication Date: 2015-03-25
广东新峰药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tablets and capsules have a single dosage form, are inconvenient to take, and are made by traditional pharmaceutical technology.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of Hou Ji Ling oral liquid, its raw materials are:

[0032] 9 parts of artificial bezoar, 150 parts of Radix isatidis, 125 parts of myrobalan

[0033] 150 parts of Platycodon, 25 parts of Tooth Soap, 125 parts of Forsythia

[0034] 250 parts of trichosanthes, 9 parts of nacre powder, 150 parts of Cantonese achyranthes

[0035] 9 pieces of borneol, 250 pieces of mountain bean root, 250 pieces of Gewang

[0036] 60 parts of cyclodextrin and 5 parts of chlorinated sucrose.

[0037] The preparation method of the Houjiling oral liquid is:

[0038] Soak the myrobalan meat with 10 times the amount of water for 1 hour, boil it for 1 hour, and then decoct the liquid for 1 hour; add 8 times the amount of water to decoction for 30 minutes, then filter the decoction; add 8 times the amount of water to decoct the medicinal residue. After 30 minutes, the decoction liquid is filtered, the filtered extracts are combined, concentrated and filtered to obtain a clear liquid A;

[0039] Add 15 ...

Embodiment 2

[0044] A kind of Hou Ji Ling oral liquid, its raw materials are:

[0045] 11 parts of artificial bezoar, 180 parts of Radix isatidis, 150 parts of myrobalan

[0046] 180 parts of bellflower, 30 parts of pig tooth soap, 150 parts of forsythia

[0047] 300 parts of trichosanthes, 11 parts of nacre powder, 183 parts of Cantonese achyranthes

[0048] 11 pieces of borneol, 300 pieces of mountain bean root, 300 pieces of Gewang

[0049] 70 parts of cyclodextrin 6 parts of stevioside.

[0050] The preparation method of the Houjiling oral liquid is:

[0051] Soak the myrobalan meat with 10 times the amount of water for 1 hour, boil it for 1 hour, and then decoct the liquid for 1 hour; add 8 times the amount of water to decoction for 30 minutes, then filter the decoction; add 8 times the amount of water to decoct the medicinal residue. After 30 minutes, the decoction liquid is filtered, the filtered extracts are combined, concentrated and filtered to obtain a clear liquid A;

[0052] Add 5 times t...

Embodiment 3

[0057] A kind of Hou Ji Ling oral liquid, its raw materials are:

[0058] 12 parts of artificial bezoar, 180 parts of Radix isatidis, 155 parts of myrobalan

[0059] 180 parts of platycodon, 35 parts of pig tooth soap, 155 parts of forsythia

[0060] 300 parts of Trichosanthes powder, 12 parts of nacre powder, 180 parts of Guangdong Achyranthes

[0061] 12 servings of borneol, 300 servings of mountain bean root, 300 servings of brother king

[0062] 80 parts of cyclodextrin 7 parts of single syrup

[0063] The preparation method of the Houjiling oral liquid is:

[0064] Soak the myrobalan meat with 15 times the amount of water for 1.5 hours, boil it for 1 hour, and then decoct the liquid to filter; add 5 times the amount of water to decoc for 30 minutes, filter the decoction; add 8 times the amount of water to decoct After 30 minutes, the decoction liquid is filtered, the filtered extracts are combined, concentrated and filtered to obtain a clear liquid A;

[0065] Add 10 times the amount...

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Abstract

The invention relates to a preparation method of a medicine, and specifically relates to a preparation method of Houjiling oral solution. The raw materials and the auxiliary materials of the traditional Chinese medicine oral solution are composed of the following components in parts by weight: 6-12 parts of calculus bovis factitius, 120-180 parts of isatis root, 95-155 parts of myrobalan pulp, 120-180 parts of platycodon grandiflorum, 15-35 parts of fructus gleditsiae, 95-155 parts of fructus forsythiae, 200-300 parts of radices trichosanthis, 6-12 parts of pearl layer powder, 120-180 parts of Guangdong achyranthes aspera, 6-12 parts of borneol, 200-300 parts of subprostrate sophora, 200-300 parts of wikstroemia indica, 40-80 parts of cyclodextrin and 3-7 parts of corrigent. According to the preparation method disclosed by the invention, the raw material medicines with greatly different dosages in the prescription are separately subjected to water extraction through three times of aqueous solution extraction to avoid loss and increase the extraction yield of aqueous solution; the objectionable odour of borneol is covered by virtue of an inclusion technology; the oral solution which is high in bioavailability, rapid in curative effect and easy to accept by the patient is prepared.

Description

Technical field [0001] The invention relates to a method for preparing medicines, in particular to a method for preparing Houjiling oral liquid. technical background [0002] Proprietary Chinese Medicine Huji Ling Tablets (WS 3 -B-2797-97 Houjiling tablet type) and Houjiling capsule (WS in the fifth volume of the original ministerial standard) 3 -B-1039-91 Hou Ji Ling capsule formulation) has the effects of clearing away heat and detoxifying, dissipating swelling and relieving pain. It can be used to treat swelling and pain of cheeks, throat swelling, sore throat, mumps, tonsillitis, Acute pharyngitis, acute attack of chronic pharyngitis and general sore throat. However, tablets and capsules have a single dosage form, are inconvenient to take, and are made by traditional pharmaceutical technology, which have disadvantages such as heavy unpleasant smell, easy disintegration and uneven content. Summary of the invention [0003] The purpose of the present invention is to make up for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61K9/08A61P11/04A61P31/04A61K35/618A61K35/413A61K31/045
CPCA61K35/413A61K9/0053A61K9/08A61K31/045A61K35/618A61K36/185A61K36/195A61K36/21A61K36/315A61K36/34A61K36/428A61K36/483A61K36/489A61K36/634A61K36/83A61K47/26A61K47/6951A61K2236/331A61K2300/00
Inventor 任宏李冠儒谢作君
Owner 广东新峰药业股份有限公司
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