Cowherb seed flavonoid glycoside/bacterial cellulose dressing for treating diabetic foot ulcers and preparation method thereof

Abstract

The invention discloses a cowherb seed flavonoid glycoside / bacterial cellulose dressing for treating diabetic foot ulcers, and relates to the field of a biological medical material and a preparation technology thereof. The preparation method comprises the following steps: dissolving a cowherb seed flavonoid glycoside medicine into a high molecular polymer solution to obtain a composite solution; adopting an immersion method to ensure that a bacterial cellulose film is immersed into the cowherb seed flavonoid glycoside / high molecular polymer solution; and performing ultraviolet crosslinking to obtain a cowherb seed flavonoid glycoside / bacterial cellulose composite film, wherein dressing is a hydrogel film prepared by compounding the high molecular polymer solution containing cowherb seed flavonoid glycoside with bacterial cellulose. The preparation process of the method disclosed by the invention is convenient to operate and low in cost, and the prepared wet hydrogel dressing for treating the diabetic foot ulcers has properties of resisting high-sugar damages, preserving moisture, absorbing the exudate of a wound, accelerating the healing of the wound, and the like. The cowherb seed flavonoid glycoside / bacterial cellulose dressing is suitable for repairing wounds of diabetic foot ulcers, lower extremity venous ulcers, pressure sores and the like.

Description

technical field

[0001] The invention relates to the technical field of biomedical materials and their preparation, in particular to a method for preparing a buliuxing flavonoid glycoside / bacterial cellulose dressing for treating diabetic foot ulcers. Background technique

[0002] In recent years, the incidence of diabetes has shown a trend of increasing substantially all over the world, and diabetic foot is one of the serious chronic complications of diabetic patients. Peripheral neuropathy caused by diabetes results in reduced or absent sensation in the foot, and patients are less aware of wounds, leading to ulcers. If the ulcer is not controlled in time and effectively, it can lead to amputation in diabetic patients. Approximately 50% of non-traumatic amputations each year are diabetic. Once diabetic foot is diagnosed, on the basis of systemic treatment including removing the cause, strictly controlling blood sugar, nourishing the whole body, and improving circulation, a...

Examples

Embodiment 1

[0024] 1. Dissolve 3 g of PVA-SbQ in 30 mL of deionized water, add 2.0 mg of flavonoid glycosides into the PVA-SbQ solution to obtain a PVA-SbQ / flavonoid glycoside solution.

[0025] 2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in PVA-SbQ solution for 24 hours, and irradiate with 400W ultraviolet light for 1 hour to obtain the vacciola flavone glycoside / bacterial cellulose composite film. After drying at room temperature, a wet antibacterial hydrogel dressing capable of treating diabetic foot ulcers is obtained. The dressing is a composite hydrogel film composed of bacterial cellulose hydrogel and PVA-SbQ solution containing wangbuliuxing flavonoid glycoside.

Embodiment 2

[0027] 1. Dissolve 3 g of PVA-SbQ in 30 mL of deionized water, add 1.8 mg of flavonoid glycosides into the PVA-SbQ solution to obtain a PVA-SbQ / flavonoid glycoside solution.

[0028]2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in PVA-SbQ solution for 24 hours, and irradiate with 400W ultraviolet light for 1 hour to obtain the vacciola flavone glycoside / bacterial cellulose composite film. After drying at room temperature, a wet antibacterial hydrogel dressing capable of treating diabetic foot ulcers is obtained. The dressing is a composite hydrogel film composed of bacterial cellulose hydrogel and PVA-SbQ solution containing wangbuliuxing flavonoid glycoside.

Embodiment 3

[0030] 1. Dissolve 3 g of PVA-SbQ in 30 mL of deionized water, add 1.6 mg of flavonoid glycosides into the PVA-SbQ solution to obtain a PVA-SbQ / flavonoid glycoside solution.

[0031] 2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in the PVA-SbQ solution for 24 hours, and irradiate with 400W ultraviolet light for 1 hour to obtain the flavonoid glycoside / bacterial cellulose composite film . After drying at room temperature, a wet antibacterial hydrogel dressing capable of treating diabetic foot ulcers is obtained. The dressing is a composite hydrogel film composed of bacterial cellulose hydrogel and PVA-SbQ solution containing wangbuliuxing flavonoid glycoside.

technical field

[0001] The invention relates to the technical field of biomedical materials and their preparation, in particular to a method for preparing a buliuxing flavonoid glycoside / bacterial cellulose dressing for treating diabetic foot ulcers. Background technique

[0002] In recent years, the incidence of diabetes has shown a trend of increasing substantially all over the world, and diabetic foot is one of the serious chronic complications of diabetic patients. Peripheral neuropathy caused by diabetes results in reduced or absent sensation in the foot, and patients are less aware of wounds, leading to ulcers. If the ulcer is not controlled in time and effectively, it can lead to amputation in diabetic patients. Approximately 50% of non-traumatic amputations each year are diabetic. Once diabetic foot is diagnosed, on the basis of systemic treatment including removing the cause, strictly controlling blood sugar, nourishing the whole body, and improving circulation, a...

Examples

Embodiment 1

[0024] 1. Dissolve 3 g of PVA-SbQ in 30 mL of deionized water, add 2.0 mg of flavonoid glycosides into the PVA-SbQ solution to obtain a PVA-SbQ / flavonoid glycoside solution.

[0025] 2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in PVA-SbQ solution for 24 hours, and irradiate with 400W ultraviolet light for 1 hour to obtain the vacciola flavone glycoside / bacterial cellulose composite film. After drying at room temperature, a wet antibacterial hydrogel dressing capable of treating diabetic foot ulcers is obtained. The dressing is a composite hydrogel film composed of bacterial cellulose hydrogel and PVA-SbQ solution containing wangbuliuxing flavonoid glycoside.

Embodiment 2

[0027] 1. Dissolve 3 g of PVA-SbQ in 30 mL of deionized water, add 1.8 mg of flavonoid glycosides into the PVA-SbQ solution to obtain a PVA-SbQ / flavonoid glycoside solution.

[0028]2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in PVA-SbQ solution for 24 hours, and irradiate with 400W ultraviolet light for 1 hour to obtain the vacciola flavone glycoside / bacterial cellulose composite film. After drying at room temperature, a wet antibacterial hydrogel dressing capable of treating diabetic foot ulcers is obtained. The dressing is a composite hydrogel film composed of bacterial cellulose hydrogel and PVA-SbQ solution containing wangbuliuxing flavonoid glycoside.

Embodiment 3

[0030] 1. Dissolve 3 g of PVA-SbQ in 30 mL of deionized water, add 1.6 mg of flavonoid glycosides into the PVA-SbQ solution to obtain a PVA-SbQ / flavonoid glycoside solution.

[0031] 2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in the PVA-SbQ solution for 24 hours, and irradiate with 400W ultraviolet light for 1 hour to obtain the flavonoid glycoside / bacterial cellulose composite film . After drying at room temperature, a wet antibacterial hydrogel dressing capable of treating diabetic foot ulcers is obtained. The dressing is a composite hydrogel film composed of bacterial cellulose hydrogel and PVA-SbQ solution containing wangbuliuxing flavonoid glycoside.

Images