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Traditional Chinese medicine composition for improving tumor microenvironment as well as preparation and preparation method of traditional Chinese medicine composition

A technology of tumor microenvironment and composition, which is applied in the direction of antineoplastic drugs, drug combinations, and medical preparations containing active ingredients, etc. To achieve the effect of enhancing anti-tumor immunity, promoting nucleic acid and protein synthesis, and improving hypoxia tolerance

Active Publication Date: 2015-04-01
于洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the raw materials used in these traditional Chinese medicine preparations have a single drug effect, and most of them have problems such as poor curative effect and slow effect; and there are many types of raw materials, and some traditional Chinese medicine raw materials do not have synergistic effects with other raw materials, which affects the overall composition of traditional Chinese medicines. curative effect
In addition, most of the existing traditional Chinese medicine compositions use the raw materials directly crushed into medicine, without extracting and separating the active ingredients in the raw materials, the non-effective ingredients are not removed, and there are many impurities, which makes the prescription of the traditional Chinese medicine composition too large, which is not conducive to Patient takes, further influences the curative effect of Chinese medicine composition

Method used

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  • Traditional Chinese medicine composition for improving tumor microenvironment as well as preparation and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for improving tumor microenvironment as well as preparation and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for improving tumor microenvironment as well as preparation and preparation method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Composition of Example 1

[0061] A traditional Chinese medicine composition for improving tumor microenvironment, which is prepared by processing the following raw materials by weight:

[0062] Ganoderma lucidum 6g Astragalus 30g Dong Lingcao 15g

[0063] Radix Paeoniae Rubra 15g, Lycium barbarum 10g.

[0064] Preparation:

[0065] a) Take Ganoderma lucidum and crush it, the sieve aperture is 28-30mm, soak the sieved Ganoderma lucidum with 8 times the amount of water, then decoct for the first time for 3.5 hours; filter the decoction, add water 6 times the amount for the second decoction for 1 hour; after filtering the decoction again, add 5 times the amount of water for the third decoction for 1 hour; combine the three decoctions, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.02 -1.15, carry out vacuum drying at a temperature of 75-85°C and a pressure of 0.04MPa to obtain fine powder of Ganoderma lucidum;

[0066] b) Take R...

Embodiment 2

[0069] Composition of Example 2

[0070] A traditional Chinese medicine composition for improving the tumor microenvironment, the traditional Chinese medicine composition is prepared by processing the raw material medicine with the following weight:

[0071] Ganoderma lucidum 8g Astragalus 26g Dong Lingcao 17g

[0072] Radix Paeoniae Rubra 12g Lycium barbarum 12g.

[0073] Preparation method: prepared according to the method described in Example 1.

Embodiment 3

[0074] Example 3 Composition

[0075] A traditional Chinese medicine composition for improving tumor microenvironment, which is prepared by processing the following raw materials by weight:

[0076] Ganoderma lucidum 5g Astragalus 35g Dong Lingcao 12g

[0077] Radix Paeoniae Rubra 17g, Lycium barbarum 8g.

[0078] Preparation method: prepared according to the method described in Example 1.

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Abstract

The invention relates to a traditional Chinese medicine composition for improving tumor microenvironment. The traditional Chinese medicine composition mainly comprises the following components in parts by weight: lucid ganoderma, astragalus membranaceus, rabdosia rubescens, radix paeoniae rubra and medlar. The invention further provides a preparation prepared from the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is capable of effectively suppressing the proliferation of tumor cells and promoting the death of the tumor cells, is high in suppression efficiency and free and toxic and side effects, and has good functions in improving the symptoms, controlling the tumor expansion, improving the living quality of the patients and prolonging the lifetime of the patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a traditional Chinese medicine composition for improving tumor microenvironment and its preparation and preparation method. Background technique [0002] The tumor microenvironment refers to the local homeostatic environment related to tumorigenesis and metastasis, which is composed of tumor cells and non-tumor cells during the growth of tumors. It mainly includes tumor cells, endothelial cells, fibroblasts, immune cells, structural components of extracellular matrix (such as collagen, elastin, etc.), and soluble substances such as cytokines and peptide growth factors secreted by them. [0003] For a long time, the research on tumor invasion and metastasis has focused on the intrinsic adhesion and migration abilities of tumor cells. However, the theory of the tumor microenvironment as a necessary functional unit to protect and support tumor occurrence, deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P35/00
CPCA61K9/2018A61K9/2059A61K36/074A61K36/481A61K36/53A61K36/65A61K36/71A61K36/815A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 于洋
Owner 于洋
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