Tracer for raising detection rate of sentinel lymph node of breast cancer and preparation method thereof

Abstract

The invention relates to a tracer for raising detection rate of sentinel lymph node of breast cancer and a preparation method of the preparation. The tracer is prepared as follows: 1ml 1% of methylthioninium chloride injection and 2.5ml 2% lidocaine hydrochloride injection are extracted by the use of a syringe; and normal saline is added to reach 5 ml so as to prepare a compound injection containing 0.2% methylene blue and 1% of lidocaine. A syringe is used to inject the prepared tracer in a point-like form under the skin around mammary areola of a patient's breast, and the total dosage of the tracer is 2ml to 4ml. Then, along the dilated blue-stained lymphatic vessels, all blue-stained lymph nodes are taken out to be inspected. The method has advantages of low cost, easy acquisition, no radiation, no requirement of special instrument detection and the like. By the method, detection rate of sentinel lymph node is raised, and cutaneous necrosis caused by methylene blue is avoided. The method is worth of popularization and application in various hospitals.

Description

technical field [0001] The present invention relates to a tracer for improving the detection rate of breast cancer sentinel lymph nodes and a preparation method of the preparation. The tracer can significantly improve the detection rate of breast cancer sentinel lymph nodes and the number of detected lymph nodes, which is the next step. Clinical treatment provides powerful guidance and can replace the use of radionuclides, preventing patients and medical staff from being exposed to nuclides. Background technique [0002] When breast cancer patients choose surgical treatment, they should first determine whether there is axillary sentinel lymph node metastasis. If the sentinel lymph nodes are not invaded by cancer, axillary lymph node dissection is not necessary; if the sentinel lymph nodes have been invaded by cancer cells, axillary lymph node dissection is generally required. Therefore, finding and detecting sentinel lymph nodes is very important to guide the next step of tr...

AI Technical Summary

Problems solved by technology

The radionuclide method needs to inject radionuclide into the patient's body, and the patient and related medical staff will be exposed to nuclide radiation to varying degrees. This reagent needs to be prepared by a special department and tested by a special instrument. The entry threshold is high and it is difficult to promote at the grassroots level; the fluorescent dye method It also requires special instrument testing, which is difficult to popularize due to its high barriers to entry and high one-time investment. At present, domestic hospitals at all levels mostly use the dye method as a tracer, among which methylene blue is cheap, easy to obtain, and does not require special instrument testing. and other advantages, the most used by medical staff

However, methylene blue as a tracer has the disadvantage that the number of detected lymph nodes is relatively small, and when the concentration of methylene blue is too high, it will also cause skin necrosis at the injection site