Cyclodextrin modified nano-silver hydrogel, and preparation method and application thereof

A technology of nano-silver sol and cyclodextrin, which is applied in the field of nano-materials, can solve the problems of low uniformity and preparation difficulties of nano-silver sol or gel, and improve the ability of adsorption and measurement, strengthen the uniformity of dispersion, and facilitate operation. Effect

Active Publication Date: 2015-06-24
HUAZHONG UNIV OF SCI & TECH
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  • Description
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Problems solved by technology

[0004] For the above defects or improvement needs of the prior art, the present invention provides a cyclodextrin-modified nano-silver hydrogel, its preparation method and application, the purpose of which is to solve the problem by modification and hydrogel preparation. The existing technical problems of nano-silver sol or gel with low uniformity or difficult preparation

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  • Cyclodextrin modified nano-silver hydrogel, and preparation method and application thereof
  • Cyclodextrin modified nano-silver hydrogel, and preparation method and application thereof
  • Cyclodextrin modified nano-silver hydrogel, and preparation method and application thereof

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preparation example Construction

[0027] The preparation method of the nano-silver hydrogel modified by reduction in situ of the dextrin comprises the following steps:

[0028] (1) Uniformly mix cyclodextrin and silver salt aqueous solution to obtain a mixture, wherein each gram of cyclodextrin corresponds to 0.2 mmol to 5 mmol of silver salt, and the concentration of silver salt is between 0.1 mmol per liter and 2.5 mmol per liter ; adjust the pH value of the mixture between 11 and 13, maintain the temperature between 50°C and 90°C, and react for 0.5 hours to 2 hours to obtain cyclodextrin-modified nano-silver sol. Preferably, the particle size of the nano-silver particles in the cyclodextrin-modified nano-silver sol is between 20nm and 50nm.

[0029] (2) The cyclodextrin-modified nano-silver sol obtained in step (1) is added with a gelling factor, and the cyclodextrin-modified nano-silver gel is obtained by freezing and gelling.

[0030] Preferably, the gelling factor is polyvinyl alcohol, and the added mas...

Embodiment 1

[0035] A nano-silver hydrogel modified by in-situ reduction of cyclodextrin, containing 0.1% by mass percentage of nano-silver particles modified by in-situ reduction of cyclodextrin, and the particle size of the cyclodextrin-modified nano-silver particles is 20 -30nm, uniformly dispersed in the hydrogel, the cyclodextrin is evenly distributed on the surface of the nano-silver particles, the mass ratio of the cyclodextrin to the nano-silver particles is 50:1, and the hydrogel modified by the cyclodextrin The tensile strength of the glue is between 3.5-4.0 MPa, and the relative standard deviation of the measured molecular surface scanning Raman signal is 8.3%. The hydrogel is preferably polyvinyl alcohol hydrogel, wherein the mass percentage of polyvinyl alcohol is 5%. The cyclodextrin is α-cyclodextrin.

[0036] The preparation method of the nano-silver hydrogel modified by reduction in situ of the dextrin comprises the following steps:

[0037] (1) Take 2 ml of 0.01 mol per l...

Embodiment 2

[0042] A nano-silver hydrogel modified by in-situ reduction of cyclodextrin, containing 0.2% by mass percentage of nano-silver particles modified by in-situ reduction of cyclodextrin, the particle size of the cyclodextrin-modified nano-silver particles is 30 -40nm, uniformly dispersed in the hydrogel, the cyclodextrin is evenly distributed on the surface of the nano-silver particles, the mass ratio of the cyclodextrin to the nano-silver particles is 10:1, and the hydrogel modified by the cyclodextrin The tensile strength of the glue is between 4.0-5.0 MPa, and the relative standard deviation of the measured molecular surface scanning Raman signal is 7.08%. The hydrogel is preferably polyvinyl alcohol hydrogel, wherein the mass percentage of polyvinyl alcohol is 10%. The cyclodextrin is β-cyclodextrin.

[0043] The preparation method of the nano-silver hydrogel modified by reduction in situ of the dextrin comprises the following steps:

[0044] (1) Take 2 milliliters of 0.01 ...

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Abstract

The invention discloses cyclodextrin modified nano-silver hydrogel, and a preparation method and an application thereof. The cyclodextrin modified nano-silver hydrogel contains 0.1%-0.4% by mass of nano-silver particles modified by in-situ reduction of cyclodextrin, the nano-silver particles are uniformly dispersed, the tensile strength of the cyclodextrin modified hydrogel is 3.5-6 MPa, and the relative standard error for measuring a molecular surface scanning Raman signal is lower than 10%. The preparation method comprises the following steps: (1) uniformly mixing cyclodextrin with a silver salt aqueous solution to obtain a mixture, and heating under an alkaline condition to react to obtain cyclodextrin modified nano-silver gel; and (2) adding a gelator, and preparing the cyclodextrin modified nano-silver hydrogel via a frozen gel forming method. The cyclodextrin modified nano-silver hydrogel provided by the invention is good in uniformity, strong in repeatability, good in mechanical property, sensitive in detection, simple to prepare and mild in reaction, and is used as a surface enhanced Raman substrate.

Description

technical field [0001] The invention belongs to the field of nanomaterials, and more specifically relates to a cyclodextrin-modified nano silver hydrogel, its preparation method and application. Background technique [0002] Due to its special surface plasmon resonance effect, nano-silver particles are widely used. Among them, the surface Raman-enhanced spectroscopy (SERS) technology using nano-silver hydrosol as a Raman substrate is one of the important application fields. SERS is a kind of molecular vibrational rotation spectrum generated by the Raman scattering effect of molecules. It can not only distinguish the measurement objects by identifying the "fingerprint spectrum" of molecules, but also because of the surface plasmon resonance effect of nano-silver and other substrate materials. It has extremely high sensitivity during determination, and even single molecule recognition can be realized under certain conditions, so it has great development prospects. With the co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 朱丽华欧阳磊唐和清
Owner HUAZHONG UNIV OF SCI & TECH
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