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Device for the perfusion of a liver graft

A technology of transplantation and liver transplantation, which is applied in the preservation, application, and animal husbandry of human or animal bodies, and can solve problems such as squeezing ischemia, interference with oxygen, and affecting the quality of organs to be transplanted, and achieves convenient application and device compact effect

Inactive Publication Date: 2015-07-01
GRIFOLS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, when it is placed against a relatively hard surface, there is a high probability of squeeze ischemia, which interferes with the entry of oxygen, cofactors and nutrients into the stem cells, which initiates a cascade of reactions at the cellular level, causing irreversible tissue damage. damage, which can adversely affect the quality of the organ to be transplanted

Method used

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  • Device for the perfusion of a liver graft
  • Device for the perfusion of a liver graft
  • Device for the perfusion of a liver graft

Examples

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Embodiment Construction

[0035] The hepatic perfusion device of the present invention has a tray on its upper part and an operating platform on the bottom to support the upper tray. This configuration allows for the separation of "clean" areas from unclean or "dirty" areas. The preferred upper tray can be prepared in a sterile form, and more preferably all its parts are of a disposable nature.

[0036] figure 1 and figure 2 An embodiment of the hepatic perfusion device of the present invention is shown. The upper tray - 16' - and the bottom console - 16 - are securely mounted together in a fixed and removable manner. The bottom console has some rails - 17, 17' - on its upper part adapted to allow the upper tray to slide on them. exist image 3 This form can be observed in , where the upper tray -16'- can slide on rails -17,17'-. The upper tray abuts against the quick action connections -10', 12', 13'- which correspond to the pipes -10, 12, 13- of the upper tray -16'-. Said rails - 17, 17' - and ...

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Abstract

The invention relates to a device for the perfusion of a human liver graft, which includes: (a) an upper tray which includes a container suitable for holding a liver graft in an inverted position with respect to the normal anatomical position, in contact with a preservative solution, an arterial perfusion circuit, and a portal perfusion circuit, separate from said arterial perfusion circuit; and (b) a lower console, which supports said tray and which includes a means for sending or supplying said preservative solution, a means for supplying power, a means for temperature control, a means for supplying oxygen, a means for controlling the flow rate and pressure, said tray and console being connected in a secure, removable manner, wherein said means for temperature control maintain the temperature of the liver graft between 0 ºC and 40 ºC.

Description

technical field [0001] The present invention relates to a hepatic perfusion device suitable for maintaining a liver or liver graft in a viable operable state in vitro to allow its further transplantation. Furthermore, the invention also relates to the use of said hepatic perfusion device for assessing the quality of a liver graft to be transplanted. Background technique [0002] Today liver transplantation is the treatment of choice and the only effective therapy for patients with liver failure which cannot be cured by any other therapeutic measures. Yet a large number of patients with liver failure who remain on the waiting list before obtaining a suitable liver for transplantation die in the final stages. Likewise, approximately 25% of liver grafts exhibit early dysfunction, which is one of the main causes of post-transplantation morbidity using liver cryopreservation or cryo-ischemia. [0003] Typically, organs from donors are preserved by means of cryopreservation (bel...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0247
Inventor 乔吉·玛丽亚·曼扎诺·里埃拉乔治·梅嫩德斯 科尔蒂纳康斯坦丁诺·方德维拉 坎波胡安·卡洛斯·加西亚-瓦尔德卡萨斯 萨尔加多
Owner GRIFOLS
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