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Plague vaccine

A vaccine, the technology of Yersinia pestis, applied in the field of plague vaccines, can solve the problem that the vaccine is not safe enough to effectively fight against bubonic plague and pneumonic plague, and achieve the effect of convenient vaccination activities, easy manufacture, and rapid protection

Active Publication Date: 2015-07-15
INST PASTEUR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, these vaccines are not safe and / or effective against bubonic and pneumonic plague

Method used

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  • Plague vaccine
  • Plague vaccine
  • Plague vaccine

Examples

Experimental program
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Effect test

Embodiment 1

[0244] We produced a Yersinia pseudotuberculosis strain that is both avirulent and genetically determined for use as a vaccine against plague. To this end, we irreversibly attenuated Yersinia pseudotuberculosis IP32953 strain by deleting genes encoding three important virulence factors (high pathogenicity island, YopK, and pH6Ag / PsaA).

[0245] We cloned the caf operon encoding Yersinia pestis F1 in a plasmid and introduced it into an attenuated Y. pseudotuberculosis strain to generate an encapsulated derivative of the attenuated Y. pseudotuberculosis strain. The resulting strain, designated V674pF1(1), produced F1 capsules in vitro and in vivo. Oral inoculation of V674pF1 allowed intestinal colonization without causing lesions in Peyer's patches and spleen. Vaccination with V674pF1 induced the humoral and cellular components of immunity at the systemic (IgG and Th1 cells) and mucosal level (IgA and Th17 cells). Single oral dose (10 8 CFU) protected 100% of animals against ...

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Abstract

The application relates to a Yersinia pseudotuberculosis cell, which comprises nucleic acid coding for expression of at least one Yersinia pestis Caf1 polypeptide or of at least one antigenic fragment of Yersinia pestis Caf1, more particularly to an attenuated Y. pseudotuberculosis cell, which expresses the Y. pestis capsule. Said Y. pseudotuberculosis cell is exceptionally efficient in protecting against both bubonic plague and pulmonary plague.

Description

technical field [0001] The present application relates to methods for vaccination especially against bubonic and pneumonic plague, as well as to their biotechnological and medical applications. The methods of the present application especially comprise Yersinia pseudotuberculosis cells or strains expressing at least one Yersinia pestis Caf1 polypeptide or at least one antigenic fragment of Yersinia pestis Caf1 . More specifically, the methods of the present application comprise Yersinia pseudotuberculosis cells or strains expressing the Yersinia pestis F1 protein or capsule. Background technique [0002] Yersinia pestis, the causative agent of plague, is one of the deadliest infectious agents to affect humans. Yersinia pestis is transmitted by infected fleas and mainly causes bubonic plague. The disease occasionally progresses to pneumonic plague, the deadliest and most contagious form of the infection, which is then transmitted from person to person via aerosols. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/36A61K39/102
CPCC12N1/36A61K39/0291A61K2039/523A61K2039/522A61K2039/542A61K2039/543C07K14/24Y02A50/30
Inventor E·卡尔涅尔C·德默尔A·德尔比斯
Owner INST PASTEUR
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