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External preparation capable of relieving swelling and pain and preparation method thereof

A technology for topical preparations, swelling and pain relief, applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the problems of few reliable drugs and unsatisfactory treatment effects for osteoarthritis , to achieve the effects of no toxic side effects, safe medication, and fast onset time

Active Publication Date: 2015-07-22
王和鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment effect of osteoarthritis has been unsatisfactory for a long time, and there are not many reliable drugs that can improve the function
[0003] After checking the Chinese Pharmacopoeia and the drug standards issued by the Ministry (Bureau), although Zhongjiefeng and Jiujiecha are widely used as raw materials for oral and injection preparations, the unilateral preparation has the effects of clearing away heat and detoxification, reducing inflammation and pain, and relaxing tendons and activating collaterals. The market volume Great, but no topical medicines

Method used

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  • External preparation capable of relieving swelling and pain and preparation method thereof
  • External preparation capable of relieving swelling and pain and preparation method thereof
  • External preparation capable of relieving swelling and pain and preparation method thereof

Examples

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preparation example Construction

[0026] A preparation method of an external preparation for reducing swelling and relieving pain, comprising the following steps:

[0027] 1) By weight, take the following raw materials:

[0028]

[0029] 2) Prepare the extracts of S. chinensis, safflower, angelica, clematis, shenjincao, and Speranza:

[0030] Take 6 kinds of raw materials of sarcophagus, safflower, angelica, clematis, shenjincao and skunkgrass, add water to decoct twice, add water 5-6 times the total weight of the above 6 kinds of raw materials each time, and decoct for 0.8 -1 hour, filter and combine the filtrate;

[0031] Concentrate the filtrate under reduced pressure to obtain a concentrated solution, the volume of the concentrated solution is 1 / 3-1 / 4 of the volume of the filtrate, then centrifuge the concentrated solution at a speed of 3000-4000r / min for 10-15min, and take the supernatant;

[0032] Pass the above supernatant through a resin column equipped with HPD-400 macroporous adsorption resin, t...

Embodiment 1

[0039] A preparation method of an external preparation for reducing swelling and relieving pain, comprising the following steps:

[0040] 1) By weight, take the following raw materials:

[0041]

[0042] 2) Prepare the extracts of S. chinensis, safflower, angelica, clematis, shenjincao, and Speranza:

[0043] Take 6 kinds of raw materials of sarcophagus, safflower, angelica, clematis, shenjincao, and sarcophagus, add water to decoct twice, add water 6 times the total weight of the above 6 kinds of raw materials each time, decoct for 1 hour, Filter and combine the filtrates;

[0044] Concentrating the filtrate under reduced pressure to obtain a concentrated solution, the volume of the concentrated solution is 1 / 4 of the volume of the filtrate, and then the concentrated solution is centrifuged at a speed of 4000r / min for 15min, and the supernatant is taken;

[0045] The above supernatant is passed through a resin column equipped with HPD-400 macroporous adsorption resin, th...

Embodiment 2

[0072] A preparation method of an external preparation for reducing swelling and relieving pain, comprising the following steps:

[0073] 1) By weight, take the following raw materials:

[0074]

[0075] 2) Prepare the extracts of S. chinensis, safflower, angelica, clematis, shenjincao, and Speranza:

[0076] Take 6 kinds of raw materials of sarcophagus, safflower, angelica, clematis, shenjincao, and sarcophagus, add water to decoct twice, add water 6 times the total weight of the above 6 kinds of raw materials each time, decoct for 1 hour, Filter and combine the filtrates;

[0077] Concentrate the filtrate under reduced pressure to obtain a concentrated solution, the volume of the concentrated solution is 1 / 4 of the volume of the filtrate, then centrifuge the concentrated solution at a speed of 3000r / min for 10min, and take the supernatant;

[0078] The above supernatant is passed through a resin column equipped with HPD-400 macroporous adsorption resin, the volume ratio...

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Abstract

The invention discloses an external preparation capable of relieving swelling and pain and a preparation method thereof. The external preparation is prepared from the following raw materials in parts by weight: 15-20 parts of herba sarcandrae, 9-15 parts of safflower carthamus, 9-15 parts of angelica sinensis, 9-15 parts of radix clematidis, 9-15 parts of lycopodium clavatum, 9-15 parts of speranskia tuberculata, 30-40 parts of camphor oil, 5-7 parts of borneol and 5-7 parts of menthol. The preparation method of the external preparation comprises the following steps: preparing an oil phase with the camphor oil, stearic acid and glyceride, preparing an aqueous phase with triethanolamine and a OP emulsifying agent, then adding the aqueous phase into the oil phase while stirring, adding an appropriate amount of essence as well as an extract prepared from herba sarcandrae and borneol-menthol ethanol liquid at the temperature of 40 DEG C, uniformly mixing by a melting method, and cooling, so as to obtain the product. The external preparation disclosed by the invention is quick in initial effect time, capable of effectively improving traditional Chinese medicinal syndromes, safe to use, free of toxic and side effects, safe and effective to treat knee osteoarthritis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an external preparation for reducing swelling and relieving pain and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) is a chronic inflammatory disease of the degenerative joint cartilage. The etiology of osteoarthritis is complex and related to many factors such as age, gender, genetics, obesity, etc., and its true pathogenesis is still not very clear. The goals of current osteoarthritis treatment are to relieve joint pain, improve function, and rebuild damaged cartilage and bone structures as much as possible. However, for a long time, the treatment effect of osteoarthritis is not ideal, and there are not many reliable drugs that can improve the function. [0003] After checking the Chinese Pharmacopoeia and the drug standards issued by the Ministry (Bureau), although Zhongjiefeng and Jiujiecha are widely used as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/716A61P19/02A61P29/00
Inventor 王和鸣蔡树河陈水金霍康富
Owner 王和鸣
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