A pharmaceutical composition for treating radiation proctitis after radiotherapy for cervical cancer

A technology for radiation proctitis and a composition, applied in the field of traditional Chinese medicine, can solve the problems of gangrene, aggravation of blood in the stool, affecting the quality of life of patients and the like

Inactive Publication Date: 2018-06-19
QINGDAO WOMEN & CHILDREN HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chronic radiation proctitis is a common complication after radiotherapy for cervical cancer. It is caused by protracted acute radiation proctitis or interstitial fibrosis after half a year of direct irradiation, and local tissue ischemia caused by obliterative endarteritis. Chronic inflammation of the rectum, intestinal stenosis, ulceration and fistula formation can cause severe radiation damage that is permanent and persistent, which brings great pain to the patient and seriously affects the quality of life of the patient
[0003] At present, there is no standard treatment at home and abroad. Systemic treatment is mainly based on anti-infection, hemostasis, and nutritional enhancement. Local treatment is mostly based on compound procaine enema (procaine + gentamicin + steroid hormones) Enemas have certain curative effects, but studies have found that long-term use of enemas containing steroid hormones can lead to Fournier's gangrene and aggravate bloody stool symptoms

Method used

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  • A pharmaceutical composition for treating radiation proctitis after radiotherapy for cervical cancer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 1.0kg of Schisandra root, 1.5kg of black petunia, 1.8kg of Sophora japonica, 0.8kg of red cardamom, 3.0kg of chestnut shell, 0.8kg of nepeta, 1.4kg of schisandra, 0.8kg of saponin thorn and 1.5kg of chicken vine , combined, crushed into granules, then add water to the above-mentioned granular medicinal materials to cover 2cm of the medicinal surface, soak for 1 hour, add water and decoct twice, add 15 times the amount of water for the first time, decoct for 3 hours, take the decoction, filter After that, add 12 times the amount of water of the medicinal materials for the second time, decoct for 2 hours, take the two decoctions and combine them, filter through 4 layers of gauze, heat and concentrate to a medicinal solution with a crude drug content of 0.5g / ml, and add 0.05% preservative , get an enema solution.

Embodiment 2

[0015] Example 2 Study on the curative effect of medicinal liquid enema on patients with chronic radiation proctitis after radiotherapy for cervical cancer

[0016] 42 hospitalized patients with chronic radiation proctitis of cervical cancer, the average age was (53.1±9.4) years old, the average time from the start of radiotherapy to the appearance of chronic radiation proctitis was (8.9±1.4) months; the total symptom score was (5.90±1.26) points; 29 of them Occasionally, blood in the stool, mucosal edema, irregular defecation, loose stool, or constipation were seen in 10 cases; blood in the stool, thickened mucosa, rectal stenosis, and difficult defecation were common in 10 cases, which could be relieved by drugs; 3 cases had whole bloody stool, ulcer or fistula formation, rectal stenosis, Severe difficulty, even obstruction. All patients were divided into experimental group and control group with 21 cases in each group by simple random number table method. There was no stat...

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PUM

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Abstract

The invention discloses medicine composition for treating radiation proctitis after radiation therapy for treating cervical cancer. The liquid medicine is prepared from raw traditional Chinese medicine materials in parts by weight as follows: 7-15 parts of roots of fructus schisandrae sphenantherae, 11-20 parts of silene adenantha Franch., 10-25 parts of flos sophorae, 6-10 parts of galanga galangal seeds, 22-40 parts of chestnut pericarp, 6-10 parts of fineleaf schizonepeta herb, 9-20 parts of humifuse euphorbia herb, 6-20 parts of Chinese honeylocust spine and 11-20 parts of poederia scandens. The medicine composition for treating chronic radiation proctitis through enema has a definite curative effect and is safe and reliable.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for enema treatment of radiation proctitis after radiotherapy for cervical cancer. Background technique [0002] Cervical cancer is the most common pelvic tumor, ranking first in gynecological malignancies in my country, and radiotherapy is the main treatment for cervical cancer. Chronic radiation proctitis is a common complication after radiotherapy for cervical cancer. It is caused by protracted acute radiation proctitis or interstitial fibrosis after half a year of direct irradiation, and local tissue ischemia caused by obliterative endarteritis. Chronic inflammation of the rectum, intestinal stenosis, ulceration and fistula formation can cause severe radiation damage that does not heal permanently, which brings great pain to the patient and seriously affects the quality of life of the patient. [0003] At present,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P35/00A61P1/00
Inventor 宋修峰庄勋慧李伟凯
Owner QINGDAO WOMEN & CHILDREN HOSPITAL
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