Application of traditional Chinese medicine composition on preparation of medicines for reversing tumor multidrug resistance

A technology of multi-drug resistance and composition, which is applied in the direction of drug combination, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problems of long cycle, few patented drugs, high risk of new drug development, etc., and achieve good anti-tumor multi-drug resistance effect

Inactive Publication Date: 2015-08-12
常熟雷允上制药有限公司
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AI Technical Summary

Problems solved by technology

Due to the high risk, large investment and long cycle of research and development of new drugs, few anti-tumor Chinese patent medicines have been released in recent years. At present, Western medicines account for 75% of the tumor drug market, while Chinese patent medicines only account for 25%. Less drug-resistant Chinese patent medicines

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  • Application of traditional Chinese medicine composition on preparation of medicines for reversing tumor multidrug resistance
  • Application of traditional Chinese medicine composition on preparation of medicines for reversing tumor multidrug resistance
  • Application of traditional Chinese medicine composition on preparation of medicines for reversing tumor multidrug resistance

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Embodiment 2

[0074] Embodiment 2 Chinese medicine composition reverses drug resistance clinical trial

[0075] Get the Chinese medicine composition provided by the invention (composed of American ginseng 50g, toad venom 0.25g, asparagus 167g, soil fritillaria 200g, acanthopanax 599g, kiwi fruit root 1000g, seabuckthorn fruit 333g, bergamot 167g oral preparation made; Tianfoshen Oral Liquid, produced by Changshu Leiyunshang Pharmaceutical Co., Ltd., Z20090947), was used to observe the therapeutic effect of 40 cases of multidrug-resistant lung cancer patients undergoing radiotherapy and chemotherapy.

[0076] 40 patients with multidrug-resistant lung cancer radiotherapy and chemotherapy took the Tianfoshen oral liquid provided by the present invention, and through 2 months of clinical observation, after taking Tianfoshen oral liquid for patients with lung cancer radiotherapy and chemotherapy, 38 patients with multidrug-resistant lung cancer underwent radiotherapy and chemotherapy. The clinic...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition on preparation of medicines for reversing tumor multidrug resistance, Chinese herbal formulas are screened through a syndrome differentiation and treatment theory according to a traditional Chinese medical theory, matching of various herbal medicines in a prescription is scientific and reasonable, a clinic effect of a Chinese herbal compound is researched deeply, and new clinic effects of the Chinese herbal compound are developed. An experiment result shows that the traditional Chinese medicine composition has an obvious restraining effect on P-glycoprotein (P-gp) in Caco-2 cells of adenocarcinoma of colon, and an effect of resisting tumor multidrug resistance is excellent. A clinic experiment result proves that the traditional Chinese medicine composition can effectively treat tumor diseases with multidrug resistance.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition in the preparation of multi-drug resistance drugs for reversal treatment of tumors. Background technique [0002] Tumor has become the number one killer threatening human survival in the 21st century, with an average of more than 6 million people dying of various tumor diseases every year. China is one of the countries with high incidence of cancer in the world, with more than 2 million new cancer patients every year, accounting for 20% of the global total, and showing a rapid growth trend every year. Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, patients often suffer from autoimmune disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61P35/00A61K35/65
Inventor 顾治平王恒斌张礼学陈力建
Owner 常熟雷允上制药有限公司
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