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The establishment method of the fingerprint of Shenzhiling Oral Liquid, its fingerprint and its application

A technology of Shenzhiling oral liquid and fingerprints, which is applied in the field of traditional Chinese medicine fingerprint analysis, can solve the problems of inability to reflect the integrity characteristics of traditional Chinese medicine compound preparations and incomplete quality of medicines, and achieve reduced manual processing, good absorption value, and precision high effect

Active Publication Date: 2017-02-22
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Shenzhiling Oral Liquid is a compound preparation, and it is obviously not comprehensive to control the quality of the drug simply by measuring the quantity of one or two index components, nor can it reflect the overall characteristics of the traditional Chinese medicine compound preparation

Method used

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  • The establishment method of the fingerprint of Shenzhiling Oral Liquid, its fingerprint and its application
  • The establishment method of the fingerprint of Shenzhiling Oral Liquid, its fingerprint and its application
  • The establishment method of the fingerprint of Shenzhiling Oral Liquid, its fingerprint and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Construction and methodological verification of fingerprints of Shenzhiling Oral Liquid

[0044] The specific steps are:

[0045] (1) Preparation of the test solution: Precisely measure 1.25ml of Shenzhiling Oral Liquid in a 25ml volumetric flask, add methanol to the volume, ultrasonically extract for 5min, place in a refrigerator at 4°C for 0.5 hour, return to room temperature, After filtering through a 0.22μm organic filter membrane, the test solution diluted 20 times can be obtained.

[0046] (2) Preparation of reference substance solution:

[0047] Accurately weigh 0.0103 g of cinnamic acid standard (batch number: 110786-200503), put it in a 100 mL volumetric flask, add methanol to dissolve and dilute to the mark to obtain a cinnamic acid solution with a concentration of 0.103 mg / mL.

[0048] Accurately weigh 0.0302 g of standard paeoniflorin (batch number: MUST-13030401), put it in a 10 mL volumetric flask, add methanol to dissolve and dilute to the ma...

Embodiment 2

[0066] Example 2: Quality Control of Shenzhiling Oral Liquid by Fingerprint

[0067] Carry out the quality control of Shenzhiling Oral Liquid by fingerprint, the specific method comprises the following steps:

[0068] (1) Construction of the fingerprint of the Shenzhiling oral liquid to be tested: get 11 batches of samples of the Shenzhiling oral liquid to be tested, and construct the fingerprint of the Shenzhiling oral liquid to be tested according to the method in Example 1;

[0069] (2) Using the "Chinese medicine chromatographic fingerprint similarity evaluation system" software to match the chromatographic peaks of the HPLC fingerprints of 11 batches of Shenzhiling oral liquid samples. Select S1 (sample numbered 1) as the reference spectrum, and the generated control fingerprint is R. Table 3 shows the similarity results between the fingerprints of each batch of samples and the control fingerprints and the fingerprints of each sample.

[0070] Table 3 Similarity value o...

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Abstract

The invention discloses a canzhiling oral solution fingerprint map building method. The map includes the following steps of preparation of a test solution, preparation of a reference solution, testing through a high performance liquid chromatograph and processing of data and a map. The invention further discloses a Canzhiling oral solution fingerprint map and a method for utilizing the fingerprint map to control quality of a Canzhiling oral solution. The Canzhiling oral solution fingerprint map building method is simple in operation, stable, reliable, high in accuracy and high in separation degree, the fingerprint map is high in stability and reproducibility and large in information quantity, and the fingerprint map is adopted as a quality control means for the Canzhiling oral solution, so that one-sidedness caused by judging of overall quality of a preparation by testing one or two chemical ingredients is avoided, and probability of artificial processing in order to enabling quality to be up to standards is lowered; samples of multiple batches are analyzed systematically, so that quality of the Canzhiling oral solution can be evaluated more comprehensively and scientifically, and product quality and efficacy are guaranteed.

Description

technical field [0001] The invention relates to a method for analyzing fingerprints of traditional Chinese medicines, in particular to a method for establishing HPLC fingerprints of Shenzhiling Oral Liquid and the fingerprint of Shenzhiling Oral Liquid obtained by the method. Background technique [0002] Shenzhiling oral liquid is a traditional Chinese medicine compound made from ten kinds of medicinal materials such as Codonopsis pilosula, Guizhi, white peony root, licorice (honey roasted), Poria cocos, dried ginger, polygala (prepared and fried), Shichangpu, keel and oyster. The preparation, which has been proven to contain a variety of biologically active substances, has a good effect of nourishing Qi and Yang, reducing phlegm and calming the nerves. It is used for the treatment of heart-qi deficiency in mild to moderate Alzheimer's disease, mainly manifested as forgetfulness and palpitations. , dizziness, insomnia, lack of breath and trouble speaking, pale tongue, indif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 聂磊臧恒昌曾英姿张丹潞乜红磊胡甜姜红
Owner SHANDONG UNIV
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