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A Calibration Method for Determination of Trace Elements in Samples by Isotope Dilution Mass Spectrometry

An isotope dilution and isotope technology, which is applied in the field of isotope dilution mass spectrometry, can solve problems such as instrument calibration methods that have not yet been discovered

Active Publication Date: 2017-08-08
BEIJING INST OF MEDICAL DEVICE TESTING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no reported calibration method for instruments with reaction cell mode

Method used

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  • A Calibration Method for Determination of Trace Elements in Samples by Isotope Dilution Mass Spectrometry
  • A Calibration Method for Determination of Trace Elements in Samples by Isotope Dilution Mass Spectrometry
  • A Calibration Method for Determination of Trace Elements in Samples by Isotope Dilution Mass Spectrometry

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1 Determination of Selenium (Se) Content in Serum by Isotope Dilution Mass Spectrometry

[0024] 1. Instruments used

[0025] Inductively coupled plasma mass spectrometry (DRC-e type, PerkinElmer, USA)

[0026] Analytical balance (XS205DualRange, d=0.01mg, Mettler company, Germany)

[0027] Milli-Q A10 ultrapure water machine (Millipore, USA)

[0028] Milli-Q A10 ultrapure water machine (Millipore, USA)

[0029] Micro-control digital display heating plate (LabTech company)

[0030] MARS Microwave Digester; (USA)

[0031] VITLAB PTFE Beaker 50mL (Germany)

[0032] 2. Reagents used

[0033] Se standard substance SRM3149 (NIST)

[0034] Human Serum Standard Material SRM909c(NIST)

[0035] BV-III grade concentrated nitric acid (Beijing Institute of Chemical Reagents)

[0036] 98.8% isotope of 78Se (Oak Ridge Laboratory)

[0037] BV-III hydrogen peroxide 30% (Beijing Chemical Reagent Research Institute);

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Abstract

The invention provides a calibration method for measuring trace elements in a sample by isotope dilution mass spectrometry, belonging to the field of isotope dilution mass spectrometry. When the isotope dilution mass spectrometry is used to determine the trace elements in the sample to be tested, when the isotope abundance ratios of the measured elements in the standard substance solution and the sample solution to be tested are not equal due to the interference of the matrix, the trace elements in the standard substance solution are determined respectively. The isotopic abundance ratio of the measured element and the isotopic abundance ratio of the measured element in the sample solution to be measured, and then calculate the correction coefficient K according to the correction method of the present invention; then use the K value to correct the measured value related to the sample to be measured , and finally realize the accurate determination of the content of trace elements in the sample to be tested by isotope dilution mass spectrometry. The method solves the influence of matrix interference of the sample to be tested on the determination accuracy when the content of trace elements in the sample to be tested is determined by isotope dilution mass spectrometry.

Description

technical field [0001] The invention belongs to the field of isotope dilution mass spectrometry determination, in particular to a calibration method when isotope dilution mass spectrometry is used to measure trace elements in samples to be tested. Background technique [0002] In the process of mass spectrometry analysis, the detection of many elements will be affected by interference factors. The instrument itself also has a detection mode for eliminating interference. There are generally two modes for eliminating interference: reaction cell mode and collision cell mode. The principle of the reaction cell mode is: a reaction cell is equipped in the inductively coupled plasma mass spectrometer, and the reaction gas (methane, oxygen, ammonia) is introduced into the reaction cell, and the interference is eliminated through the chemical reaction between the reaction gas and the interference. For example: ArH pair 40 The interference of Ca can be eliminated by the reaction mode...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62G01N27/626
Inventor 李胜民王军孙京昇刘毅杨忠向华王会如
Owner BEIJING INST OF MEDICAL DEVICE TESTING
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