Stable anti-VEGF antibody preparation and application thereof
A liquid preparation and preparation technology, which is applied in the field of stable anti-VEGF antibody preparations, can solve problems such as the increase of polymers and charge isomers, product quality consistency and safety impact, and low stability of anti-VEGF antibody preparations
Active Publication Date: 2015-09-23
INNOVENT BIOLOGICS (SUZHOU) CO LTD
View PDF5 Cites 12 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0003] Most of the currently known anti-VEGF antibody preparations are not stable, and are prone to physical changes (such as aggregation and fragmentation) and chemical changes (such as deamidation, oxidation) during storage, resulting in the increase of polymers and charge variants. Potentially affect the quality consistency and safety of the product
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0092] Each component and content in the preparation are as shown in Table 1:
[0093] Table 1
[0094] anti-VEGF monoclonal antibody
Embodiment 2
[0096] Each component and content in the preparation are as shown in Table 2:
[0097] Table 2
[0098] anti-VEGF monoclonal antibody
[0099] Polysorbate 20
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Property | Measurement | Unit |
---|---|---|
concentration | aaaaa | aaaaa |
concentration | aaaaa | aaaaa |
concentration | aaaaa | aaaaa |
Login to View More
Abstract
The invention relates to a stable anti-VEGF antibody preparation and an application thereof, specifically the preparation comprises (i) therapeutically effective amounts of an anti-VEGF antibody, (ii) a buffer system containing 1.0-5.0mg / ml of sodium acetate trihydrate, (iii) an osmotic pressure regulator, and optionally (iv) surfactant, wherein the pH of the preparation ranges from 5.0 to 6.0. The preparation disclosed by the invention can be used for effectively reducing the physical and chemical degradation reaction rates of an anti-VEGF monoclonal antibody, improving antibody stability and prolonging the shelf life of a finished product; in addition, the invention also discloses a method for stabilizing the antibody and an application of the preparation.
Description
technical field [0001] The invention relates to the field of biotechnology, in particular to a stable anti-VEGF antibody preparation and its application. Background technique [0002] Anti-VEGF monoclonal antibody drugs for treatment can specifically bind to VEGF-A and inhibit the binding of VEGF-A to VEGF-R1 and VEGF-R2, blocking PI3K-Akt / PKB and Ras-Raf-MEK-ERK and other signaling pathways It inhibits the growth, proliferation and migration of vascular endothelial cells and angiogenesis, reduces the permeability of blood vessels, blocks the blood supply of tumor tissues, inhibits the proliferation and metastasis of tumor cells, induces apoptosis of tumor cells, and produces anti-tumor effects. [0003] Most of the currently known anti-VEGF antibody preparations are not stable, and are prone to physical changes (such as aggregation and fragmentation) and chemical changes (such as deamidation, oxidation) during storage, resulting in the increase of polymers and charge varian...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K47/26A61K47/34A61K47/02A61P35/00
Inventor 汪音爵黄小乐姚宗仁
Owner INNOVENT BIOLOGICS (SUZHOU) CO LTD
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com