131Cs particle and preparation process thereof

Abstract

The invention discloses a 131Cs particle used for inter-tissue close-range treatment of tumors and a preparation process thereof, belonging to the technical field if medical active particles. The 131Cs particle comprises a particle inner core and a particle shell, wherein the particle inner core is sealed in the particle shell, the particle inner core is a support rod internally and externally provided with uniformly distributed 131Cs, and the particle shell is a titanium pipe or titanium alloy pipe. The process comprises the following steps: adding a cesium nitrate-131 solution and a cesium nitrate solution into a solvent and carrying out uniform mixing under stirring, wherein the solvent is a volatile solvent miscible with water; adding an adsorbent as a supporter into a mixed solution obtained in the previous step and carrying out uniform mixing under stirring; removing the solvent and drying the supporter; grinding the supporter, adding a binder, carrying out uniform mixing and compressing the obtained mixture into the support rod with a diameter of 0.3 to 0.5 mm and a length of 2 to 5 mm; and finally, drying the support rod in the air and sealing the support rod in the medical high-purity titanium or titanium alloy pipe. The particle prepared in the process can be used for inter-tissue close-range treatment of tumors.

Description

technical field [0001] The invention belongs to the technical field of medical radioactive particles, and in particular relates to an interstitial brachytherapy for tumors 131 Cs particle and its preparation process. Background technique [0002] Malignant tumors have always been a major disease that threatens human health, and interstitial brachytherapy of tumors using radioactive particles is a technology developed in recent decades. This technology uses the low-energy rays emitted during the radionuclide decay process to continuously irradiate the tumor at close range to achieve the purpose of relief and treatment. It has been widely used in the treatment of various solid tumors, such as prostate cancer, breast cancer, liver cancer, Ovarian cancer, brain tumor, orbital tumor, etc., and achieved good clinical results. Nuclides commonly used in interstitial brachytherapy for tumors are 125 I. 103 Pd, 131 Cs et al. in 125 I and 103 There are many studies on Pd, 125 ...

AI Technical Summary

Problems solved by technology

However, cesium is a group IA element with a low melting point and lively nature. It is easily oxidized in the air and can react violently with water to generate hydrogen gas and may cause an explosion.

therefore 131 The preparation of Cs particles cannot use conventional electrodeposition or chemical deposition processes

At present, there are very few researches and reports in this technical field both at home and abroad. 131 The application of Cs particles in tumor therapy urgently needs a feasible and effective 131 Cs particle and its preparation process