Method for determination of padimate in cosmetics

A technique for the determination of patimamate and its determination method, which is applied in the field of determination of pademamate in cosmetics, and achieves the effects of high sensitivity and optimized high-performance liquid chromatography conditions

Active Publication Date: 2015-11-18
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Abstract
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  • Claims
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  • Method for determination of padimate in cosmetics
  • Method for determination of padimate in cosmetics
  • Method for determination of padimate in cosmetics

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Embodiment 1

[0054] 1. Reagents and materials

[0055] Unless otherwise specified, the reagents used are of analytical grade, and the water is the experimental water specified in GB / T6682-2008.

[0056] Methanol: chromatographically pure.

[0057] Tetrahydrofuran: chromatographically pure.

[0058] Sodium chloride.

[0059] Patrimate standard.

[0060] Pademamate mixed standard stock solution: Weigh an appropriate amount of Pademamate A and Pademamate O standard products (accurate to 0.0001g), and prepare a single-standard stock solution containing methanol 1000mg / L with methanol, and then use Methanol was prepared as a 100mg / L mixed standard stock solution.

[0061] Partimate mixed standard working solution: use methanol to prepare the mixed standard stock solution of Patimate to a concentration of 0.02, 0.05, 0.1, 0.2, 0.5, 1, 2, 5, 10mg / L methanol mixed standard working solution.

[0062] 2. Instruments and equipment

[0063] High-performance liquid chromatography: equipped with a...

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Abstract

The invention discloses a method for determination of padimate in cosmetics, wherein the method includes the following steps: (1) pretreating samples; (2) analyzing padimate by high performance liquid chromatography, and optimizing high performance liquid chromatography conditions; and (3) drawing a standard working curve, quantifying by adopting an external standard method, and calculating the content of padimate. The method for determination of padimate in the cosmetics adopts the high performance liquid chromatography for simultaneous determination of padimate A and padimate O in the cosmetics; the samples detected to be positive by the high performance liquid chromatography are further identified by using high performance liquid chromatography-mass spectrometry/mass spectrometry. The method is accurate and fast, is high in sensitivity, and has a great significance for monitoring of the cosmetics quality safety risks.

Description

technical field [0001] The invention relates to a method for determining chemical substances, in particular to a method for determining pademalate in cosmetics. Background technique [0002] Pademamate is divided into pademalate A and pademalate O. Patimate A, relative molecular mass: 235.36, CAS: 14779-78-3, molecular formula: C 14 h 21 NO 2 , the structural formula is as follows: [0003] [0004] Patimate O, relative molecular mass: 277.41, CAS: 21245-02-3, molecular formula: C 17 h 27 NO 2 , the structural formula is as follows: [0005] [0006] Because of its irritating effect on the eyes, respiratory tract and skin, my country's "Cosmetic Hygienic Standards" clearly stipulates that no pademalate A should be added to cosmetics, and pademalate O is an anti-ultraviolet absorber. Widely used in cosmetics and other light-transmitting and anti-sun industrial products, the limit is 8%. There is no report on the detection method of patimate in cosmetics at home ...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 马强郭项雨白桦孟宪双
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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