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Method for measuring free ibuprofen in arginine ibuprofen by virtue of high-performance liquid chromatography

A technology of high performance liquid chromatography and determination method, which is applied in the field of high performance liquid chromatography determination of free ibuprofen in argininoprofen, can solve problems such as inaccuracy and low specificity, and achieves reduction of sample decomposition and optimization of high efficiency Liquid chromatography conditions, the effect of ensuring reliability

Active Publication Date: 2015-04-22
仁合熙德隆药业有限公司
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Problems solved by technology

An important test item in the quality standard of argininoprofen is to determine the content of free ibuprofen in the product. Currently, there is no test method given in the Pharmacopoeia. The quality control of the product is carried out by each enterprise using its own internal control standards, generally UV-Vis Spectrophotometry, but it has the disadvantages of low specificity and inaccuracy

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  • Method for measuring free ibuprofen in arginine ibuprofen by virtue of high-performance liquid chromatography
  • Method for measuring free ibuprofen in arginine ibuprofen by virtue of high-performance liquid chromatography
  • Method for measuring free ibuprofen in arginine ibuprofen by virtue of high-performance liquid chromatography

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Embodiment

[0021] A high performance liquid chromatography method for the determination of free ibuprofen in argininoprofen is carried out according to the following steps:

[0022] 1) High performance liquid chromatography conditions: high performance liquid chromatography, Shimadzu LC-20AT, liquid chromatography conditions: C18 column (4.6mm×250mm, 5um), column temperature 30℃, ultraviolet detector, detection wavelength 220nm; flow Phase: methanol: water (containing 2% H3PO4, pH=2.5)=75:25, flow rate: 1.0ml / min

[0023] 2) Preparation of the test solution: Weigh 1g of argininoprofen sample, add 20ml of chloroform, extract with magnetic stirring for 10min, filter out the chloroform, and repeat the extraction twice with 20ml of chloroform on the filter residue, and combine the trichloromethane Methane extraction solution, the filtrate was evaporated to dryness in a 50°C water bath under reduced pressure, and chloroform was recovered. The residue obtained after concentration was dissolved in m...

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Abstract

The invention discloses a method for measuring free ibuprofen in arginine ibuprofen by virtue of a high-performance liquid chromatography. The method mainly comprises the steps of extracting free ibuprofen in a sample by virtue of a fat soluble organic solvent, measuring by virtue of the high-performance liquid chromatography after the constant volume is achieved, and measuring the content of the free ibuprofen in the sample by virtue of an external standard method. The method has the advantages of being stable, accurate, reliable, good in repeatability and convenient to generalize and use.

Description

Technical field [0001] The invention relates to a method for analyzing drugs, in particular to a method for determining free ibuprofen in argininoprofen by high performance liquid chromatography. Background technique [0002] Ibuprfen is an alkyl phenylpropionic acid anti-inflammatory, antipyretic and analgesic created by the British Boots company in 1967 and listed in 1969. It has definite curative effect, low side effects and high safety. But it is almost insoluble in water, and ordinary oral tablets dissolve slowly in the gastrointestinal tract and eliminate quickly in the body. In the treatment of chronic diseases such as rheumatism and rheumatoid arthritis, long-term frequent and high-dose medication is required, which can easily lead to gastrointestinal bleeding and cause certain damage to the kidneys, causing some patients to be unable to continue treatment. In order to meet the clinical requirements, a variety of dosage forms have been designed successively abroad. New d...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 蒲含林朱义波相东方
Owner 仁合熙德隆药业有限公司
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