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Antarctic krill oil nanostructured lipid carrier and preparation method thereof

A technology of nanostructured lipids and Antarctic krill oil, which is applied in liposome delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the limitations of hydrophobic properties, sensitivity to light, oxygen, heat, lack of effective Methods and other issues, to achieve good physical and chemical stability, high repeatability, good physical stability

Active Publication Date: 2019-08-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Antarctic krill oil is sensitive to light, oxygen and heat, prone to oxidation, and its hydrophobic properties limit its application in food
At present, most Antarctic krill oil exists in the form of capsules, and there is still a lack of effective means to apply it to water-soluble foods

Method used

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  • Antarctic krill oil nanostructured lipid carrier and preparation method thereof
  • Antarctic krill oil nanostructured lipid carrier and preparation method thereof
  • Antarctic krill oil nanostructured lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the formula of Antarctic krill oil nanostructure lipid carrier is made up of the following components by mass percentage:

[0038] Antarctic krill oil 6.5%; palm stearin 3.5%; soybean lecithin 1.07%; water 88.93%.

[0039] The preparation method of the Antarctic krill oil nanostructure lipid carrier is as follows:

[0040] (1) melting and mixing solid lipid and Antarctic krill oil at 70°C;

[0041] (2) Add the emulsifier into the water, stir and dissolve, and preheat at 70°C;

[0042] (3) The molten mixed lipid obtained in step (1) is added dropwise to the aqueous solution obtained in step (2) while hot (the above-mentioned adding time is about 30s), and the dropping process adopts a magnetic stirrer to stir (the rotating speed is 4000rpm); After the dropwise addition, continue magnetic stirring for 1 minute to make colostrum;

[0043] (4) Pour the colostrum obtained in step (3) into a high-pressure homogenizer with a set pressure of 80 MPa and circulat...

Embodiment 2

[0046] Embodiment 2, Antarctic krill oil nanostructured lipid carrier formula consists of the following components in mass percentage:

[0047] Antarctic Krill Oil 5%; Glyceryl Tristearate 5%; Tween 1%; Water 89%.

[0048] The preparation method of the Antarctic krill oil nanostructure lipid carrier is as follows:

[0049] (1) melting and mixing solid lipid and Antarctic krill oil at 70°C;

[0050] (2) Add the emulsifier into the water, stir and dissolve, and preheat at 70°C;

[0051] (3) The molten mixed lipid obtained in step (1) is added dropwise to the aqueous solution obtained in step (2) while hot (the above-mentioned adding time is about 30s), and the dropping process adopts a magnetic stirrer to stir (the rotating speed is 4000rpm); After the dropwise addition, continue magnetic stirring for 1 minute to make colostrum;

[0052] (4) the colostrum obtained in step (3) is ultrasonically pulverized with 200W power for 5 minutes through an ultrasonic probe;

[0053] (5)...

Embodiment 3

[0055] Embodiment 3, Antarctic krill oil nanostructured lipid carrier formula consists of the following components in mass percentage:

[0056] Antarctic krill oil 3.5%; palm stearin 6.5%; Tween 0.9%; water 89.1%.

[0057] The preparation method is identical to Example 1.

[0058] The average particle diameter of the Antarctic krill oil nanostructured lipid carrier in the aqueous dispersion prepared in Example 3 was about 160.5 nm.

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Abstract

The invention discloses a euphausia superba oil nanostructure lipid carrier. The euphausia superba oil nanostructure lipid carrier is prepared from, by mass, 3.5-6.5% of euphausia superba oil, 3.5-6.5% of solid lipid, 0.9-1.1% of emulgator and the balance water. The invention further provides a preparing method of the euphausia superba oil nanostructure lipid carrier. The preparing method includes the following steps that 1, the solid lipid and the euphausia superba oil are fused and mixed; 2, the emulgator is added into water and stirred until the emulgator is dissolved; 3, under the magnetic stirring condition, the fused mixed lipid is dripped into a water solution obtained in the step 2 while the lipid is hot; 4, primary emulsion obtained in the step 3 is homogenized; 5, the micro emulsion obtained after homogenizing in the step 4 is naturally cooled to the room temperature to obtain an aqueous dispersion of the euphausia superba oil nanostructure lipid carrier. Storage stability and bioavailability of the euphausia superba oil can be improved, and application of the euphausia superba oil to water-soluble food is broadened.

Description

technical field [0001] The invention relates to a preparation method of an Antarctic krill oil nanostructure lipid carrier. Background technique [0002] Antarctic krill oil is obtained from wild Antarctic krill in pure sea areas, which contains a large amount of phospholipids, omega-3 polyunsaturated fatty acids, astaxanthin, vitamins A, D, E, animal flavonoids, chitin and trace elements And other active substances, safe and non-toxic side effects. And a large number of studies have shown that Antarctic krill oil is the only natural omega-3 combined with phospholipids in nature, and then bonded with super natural antioxidants, which has both high bioavailability and super antioxidant power. Active multi-functional complex molecules, and its phospholipids are very close to those of human cells, so phospholipids rich in omega-3 polyunsaturated fatty acids are very easy for the body to absorb and utilize. At present, research on Antarctic krill oil at home and abroad is main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K35/612A61K47/14A23L33/00
Inventor 朱加进庄攀栾兰兰孙启
Owner ZHEJIANG UNIV
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