Crystal form of salt formed from vinpocetine and phosphoric acid, and preparation method

A kind of technology of vinpocetine and phosphoric acid, applied in the new crystal form of vinpocetine and phosphoric acid formed salt and preparation thereof, the salt crystal formed by vinpocetine and phosphoric acid and its preparation field
CN105153147AInactive Publication Date: 2015-12-16JIANGSU QINGJIANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU QINGJIANG PHARMA
Publication Date
2015-12-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a crystal form of a salt formed from vinpocetine and phosphoric acid, and a preparation method, and relates to the technical field of discovery and preparation of a crystal form of a pharmaceutical salt. The prepared salt formed from vinpocetine and phosphoric acid is detected through analytical methods, such as thermal gravimetric analysis (TGA), X-ray powder diffraction (P-XRD), X-ray single crystal diffraction (S-XRD), differential scanning calorimetry (DSC), and infrared spectroscopy (IR). Vinpocetine is a indissolvable medicine (the solubility of which is about 5 [mu]g / mL and pKa of which is 7.31), while it is proved through detection that the salt prepared from vinpocetine and phosphoric acid has excellent solubility and stability. Development of the novel salt form establishes foundation for development and application of new formulation.
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Description

technical field

[0001] The present invention relates to a salt crystal formed by vinpocetine and phosphoric acid and a preparation method thereof. Specifically, the present invention relates to a new crystal form of salt formed by vinpocetine and phosphoric acid and a preparation method thereof, belonging to the discovery and preparation technology of pharmaceutical crystal forms field. Background technique

[0002] Vinpocetine was first developed by the Hungarian Gedeon Richter company and launched in 1978. Its pharmacological effects include: increasing cerebral blood flow; promoting the uptake and utilization of glucose and oxygen in the brain, increasing ATP, reducing the production of lactic acid during ischemia and hypoxia; preventing brain cell excitotoxic death (excessive stimulation caused by excitatory amino acids) body excitation); reduce brain hypoxic damage, protect neurons; enhance dopaminergic, serotonergic and noradrenergic nerve functions; prevent ischemic ...

Claims

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