Application of fennel extract in preparation of antibacterial drugs

A technology of fine fennel and antibacterial drugs, which is applied in the field of biomedicine and can solve the problems of bacterial flora imbalance, deafness, and large toxic and side effects of antibiotics

Active Publication Date: 2019-01-08
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics are the first choice for bacterial infections. The initial application of antibiotics has effectively controlled many serious bacterial infections in humans, but the side effects of antibiotics are quite large, and severe cases can cause side effects such as deafness; at the same time, long-term use of antibiotics is easy to cause The imbalance of flora in the body induces superinfection of multidrug-resistant pathogenic bacteria and fungi, which increases the difficulty of treatment

Method used

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  • Application of fennel extract in preparation of antibacterial drugs
  • Application of fennel extract in preparation of antibacterial drugs
  • Application of fennel extract in preparation of antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1 Preparation of Single Traditional Chinese Medicine Antibacterial Tablet

[0083] Take 1.5 kg of fennel medicinal material, grind it to 20 mesh, add 8 times its mass of ethanol with a volume concentration of 10%, and extract at room temperature under the condition that the number of extractions is 3 times and each time is 24 hours. Extraction, to obtain the extract, the extract under the condition of a vacuum of -0.09MPa to recover the ethanol to the liquid extract through vacuum decompression, to obtain the crude extract of fennel fennel.

[0084] The crude extract of fennel fennel was purified by D101 macroporous resin column, and then eluted with 5 times the column volume of water and 95% ethanol until the collected liquid was colorless, and the alcohol eluate was collected, and the ethanol was eluted Under the condition that the vacuum degree is 0 MPa, the ethanol is recovered by vacuum decompression to dryness, and the extract of fennel fennel is obtained....

Embodiment 2

[0086] Example 2 Preparation of single traditional Chinese medicine antibacterial capsules

[0087] Take 2.5 kg of fennel medicinal material, grind it to 40 mesh, add 10 times its mass of ethanol with a volume concentration of 50%, and carry out leaching at room temperature under the conditions of 2 extraction times and 36 hours each time. Extraction, to obtain the extract, the extract is under the condition of a vacuum of -0.06MPa to recover the ethanol to the liquid extract through vacuum decompression, to obtain the crude extract of fennel fennel.

[0088] The crude extract of fennel fennel was purified by D101 macroporous resin column, and then eluted with 5 times the column volume of water and 70% ethanol until the collected liquid was colorless, and the alcohol eluate was collected, and the ethanol was eluted Under the condition that the degree of vacuum is -0.04MPa, the ethanol is recovered by vacuum decompression to dryness, and the extract of fennel fennel is obtained...

Embodiment 3

[0090] Example 3 Preparation of Single Traditional Chinese Medicine Antibacterial Oral Liquid

[0091] Take 5 kg of fennel medicinal material, grind it to 20 mesh, add 10 times its mass of ethanol with a volume concentration of 65%, and extract at room temperature under the conditions of 2 extraction times and 36 hours each time , to obtain the extract, the extract is under the condition of a vacuum of -0.05MPa to recover the ethanol to the liquid extract through vacuum decompression, and obtain the crude extract of fennel fennel.

[0092] The fennel extract was purified by a D101 macroporous resin column, and then eluted with 5 times the column volume of water and 95% ethanol until the collected solution was colorless, and the alcohol eluate was collected. Under the condition of vacuum degree of -0.03MPa, the ethanol is recovered by vacuum decompression, and the extract is made into a fluid extract with a relative density of 1.2-1.3, so as to obtain the crude extract of fenne...

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Abstract

The invention relates to application of a slender-fruited hypecoum extract in preparation of antibacterial medicines. The slender-fruited hypecoum extract is characterized by being prepared from dry herb of hypecoumleptocarpum hook.f.et thoms. foeniculum of poppy family by adopting alcohol extraction and macroporous resin column purification with total alkaloid content of 30-95 percent and total flavonoid content of 5-60 percent. Various preparations of antibacterial medicines with chemical drugs or traditional Chinese herbs or natural drugs at least comprise the slender-fruited hypecoum extract. In-vivo and in-vitro experiments prove that the slender-fruited hypecoum extract can be used for preparing antibacterial medicines.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of the fennel fennel extract in the preparation of antibacterial drugs. Background technique [0002] When the defense function of the whole body is reduced, the invading bacteria or fungi from the outside multiply rapidly, which can easily cause infectious diseases. Antibiotics are the first choice for bacterial infections. The initial application of antibiotics has effectively controlled many serious bacterial infections in humans, but the side effects of antibiotics are quite large, and severe cases can cause side effects such as deafness; at the same time, long-term use of antibiotics is easy to cause The imbalance of flora in the body induces superinfection of multidrug-resistant pathogenic bacteria and fungi, which increases the difficulty of treatment. [0003] The antibacterial compound or single preparation made from natural plants has been more and more resea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P31/04
Inventor 文怀秀邵赟梅丽娟陶燕铎苑祥
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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