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Methods for treatment of nephrotic syndrome and related conditions

A technology for nephrotic syndrome and disease state, which is applied in chemical instruments and methods, botanical equipment and methods, biochemical equipment and methods, etc., and can solve problems such as unestablished links and complicated disease mechanism research.

Inactive Publication Date: 2016-01-06
苏曼特 S 丘格
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the role of Angptl4 in nephrotic syndromes (such as but not limited to MCD, FSGS, MN / MGN and MPGN) and related conditions (such as but not limited to proteinuria) has not been reported before
Furthermore, the association between proteinuria and glucocorticoid sensitivity in nephrotic syndrome and the link between proteinuria and hypertriglyceridemia (two key components of nephrotic syndrome) has not been established
Therapies Designed to Reduce Proteinuria Further Complicate Study of Disease Mechanisms

Method used

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  • Methods for treatment of nephrotic syndrome and related conditions
  • Methods for treatment of nephrotic syndrome and related conditions
  • Methods for treatment of nephrotic syndrome and related conditions

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Embodiment Construction

[0059] In the following discussion, certain articles and methods will be described for background and introductory purposes. Nothing contained herein should be construed as an "admission" of prior art. Applicants expressly reserve the right, where appropriate, to demonstrate that the articles and methods cited herein do not constitute prior art under applicable statutory provisions.

[0060] When studying nephrotic syndrome, it is noteworthy that Angptl4 secreted from podocytes induces proteinuria. More importantly, as described herein, circulating Angptl4 reduced proteinuria in transgenic animal models. Elevated levels of Angptl4 are noted in nephrotic syndromes such as MCD and MN, but elevated circulating levels of Angptl4 are not associated with the cause of nephrotic syndrome.

[0061] Although elevated Angptl4 levels have been shown to treat nephrotic syndrome and reduce associated proteinuria, increased Angptl4 in circulation has been observed to induce hyperlipidemia ...

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Abstract

The present disclosure provides a polypeptide and method for treating and / or preventing nephrotic syndrome, such as but not limited to those associated with minimal change disease and membranous nephropathy, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation of US Application 13 / 841,240 (pending), filed March 15, 2013. US Application No. 13 / 841,240 is a continuation-in-part of US Application No. 13 / 364,962 (pending), filed February 2, 2012. US Application 13 / 364,962 is a continuation of International Application PCT / US11 / 39255, filed June 6, 2011 (abstained). International application PCT / US11 / 39255 claims priority to US application 61 / 351,866, filed June 5, 2010 (which has expired). US application 13 / 364,962 claims priority to US application 61 / 438,854, filed February 2, 2011 (which has expired). US application 13 / 841,240 is incorporated herein by reference in its entirety. [0003] Statement Regarding Federally Funded Research [0004] Funding for the work described herein was provided at least in part through National Institutes of Health (NIH) grant numbers R01DK077073 and R01DK090035, and the US Government has certain rights in th...

Claims

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Application Information

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IPC IPC(8): C07K14/47A61K38/16C12N15/12C12N15/63A61P3/00
CPCA61K38/00C07K14/515A61P13/12A61P3/00A61P43/00A61P3/10
Inventor 苏曼特·S·丘格
Owner 苏曼特 S 丘格
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