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Pharmaceutical composition for treating children chronic simple rhinitis

A simple, compositional technology, applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as drug resistance, toxic side effects, poisoning reactions, arrhythmia, etc., and achieve significant curative effects.

Inactive Publication Date: 2016-02-17
钟柱林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the diagnosis of this disease is clear in western medicine and great progress has been made in the treatment, most of the methods used will destroy the normal physiological structure of the nasal cavity, and the long-term efficacy of local treatment with western medicine is not satisfactory, and drug resistance is prone to occur And toxic side effects, expensive, such as commonly used local western medicine 1% nitrofurazone and ephedrine nasal drops are prone to drug-induced rhinitis, systemic poisoning reactions, arrhythmia and other problems

Method used

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  • Pharmaceutical composition for treating children chronic simple rhinitis

Examples

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Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 Chinese medicine granule

[0015] Weigh 9kg of ebony plum, 15kg of plantain leaf, 13kg of saponins, 10kg of privet privet, 30kg of winter melon seeds, 6kg of chuanxiong, 8kg of osmanthus seeds and 8kg of fleas, combine them, add water to decoct twice, and add water for the first time to be the weight of the medicinal materials. 10 times the amount, decoct for 1.5 hours, add water for the second time to 8 times the weight of the medicinal material, decoct for 1.5 hours, combine the decoction, concentrate under 0.07MPa pressure to an extract with a relative density of 1.15 at 65°C, add ethanol Make the alcohol content reach 75% (v / v), stir, stand still for 24 hours, filter, and concentrate the filtrate under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and recover ethanol to obtain concentrated liquid, the concentrated solution is spray-dried (the conditions are that the inlet air temperature is 100°C, the out...

Embodiment 2

[0016] The preparation of embodiment 2 Chinese medicine granules

[0017] Weigh 10kg of ebony plum, 18kg of plantain leaf, 13kg of saponins, 13kg of privet privet, 28kg of winter melon seeds, 7kg of chuanxiong, 10kg of osmanthus, and 10kg of fleas. 10 times the amount, decoct for 1.5 hours, add water for the second time to 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, concentrate under reduced pressure at 0.07MPa to 65°C and extract with a relative density of 1.15, Add ethanol to make the alcohol content reach 75% (v / v), stir, let stand for 24 hours, filter, and concentrate the filtrate under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and recover ethanol. To obtain a concentrated solution, the concentrated solution is spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the...

Embodiment 3

[0018] The clinical application of embodiment 3 traditional Chinese medicine granule treatment children's chronic simple rhinitis

[0019] 54 cases of children with chronic simple rhinitis, manifested as: runny nose, mostly mucopurulent or mucoid, alternating and intermittent rhinitis, often accompanied by hyposmia, dizziness and headache, and closed nasal pronunciation; Inferior turbinate showed smooth, elastic pus swelling, dark red mucous membrane, dilated blood vessels, highly sensitive to vasoconstrictors, and more nasal secretions. Among them, there were 31 males and 23 females; the oldest was 13 years old, the youngest was 6 years old, with an average of (8.8±1.5) years old; the longest course of disease was 3 years, and the shortest was 2 months, with an average of (12.7±1.3) months. They were randomly divided into a test group and a control group with 27 cases each. There was no statistically significant difference in general data between the two groups and they were ...

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Abstract

The invention discloses a pharmaceutical composition for treating children chronic simple rhinitis. The pharmaceutical composition is prepared from active ingredients and pharmaceutically acceptable auxiliary materials. The active ingredients include, by weight, 7-12 parts of smoked plums, 12-18 parts of Japanese banana leaves, 10-17 parts of spina gleditsiae, 8-13 parts of ligustrum lucidum ait, 25-35 parts of Chinese waxgourd seeds, 4-8 parts of ligusticum wallichii, 6-10 parts of osmanthus fragrans, and 6-10 parts of manyleaf paris rhizome, and the active ingredients are obtained through water extraction and alcohol precipitation. The pharmaceutical composition has a remarkable curative effect on chronic rhinitis and is especially suitable for treating children chronic simple rhinitis. Symptoms including nasal obstruction, running nose and dizziness and headache disappear completely after sick children take the medicine for 1-2 treatment courses, and relapse after recovery is avoided.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating children with chronic simple rhinitis and an application thereof. Background technique [0002] Chronic rhinitis can be divided into chronic simple rhinitis and chronic hypertrophic rhinitis. Chronic simple rhinitis and chronic hypertrophic rhinitis are two stages of a disease. There is no clear boundary in pathology during the transformation process from chronic simple rhinitis to chronic hypertrophic rhinitis , and there are often transitional types. Chronic simple rhinitis is a reversible inflammatory disease of the nasal mucosa caused by local, systemic or environmental factors. The pathological characteristics of chronic simple rhinitis are: due to neurovascular dysfunction, chronic expansion of nasal mucosa deep arteries and veins, turbinate Swelling occurs, but the superficial blood vessels do not ...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P11/02
CPCA61K36/736A61K9/1652A61K36/236A61K36/42A61K36/483A61K36/63A61K36/638A61K36/88A61K36/896A61K2236/331A61K2300/00
Inventor 钟柱林
Owner 钟柱林
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