A kind of erythropoietin mimic peptide and its preparation method and application

An erythropoietin and peptidomimetic technology, applied in the field of erythropoietin peptidomimetic and its preparation and use, can solve the problems of low EC50 and limitation, and achieve the effect of prolonging half-life
CN105367629BActive Publication Date: 2019-01-08TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2019-01-08

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Abstract

The invention relates to a hmopoietin mimic peptide with long-acting erythropoiesis-promoting function and pharmaceutical salts. The invention also provides a preparation method for the above mopoietin mimic peptide and application of the mopoietin mimic peptide to prepare medicines treating diseases with the character of erythrocyte lack, erythropoietin lack, or erythrocyte population lack or defect. The provided hemopoietin mimic peptide is an alkyl acid conjugate of a lysine (K) side-chain dissociated amino at the terminal of a peptide chain shown as SEQ ID NO:1, the structural general formula is shown as a formula I: GGLYACHMGPITNalVCQPLRSarK-X, wherein two cysteine form a disulfide bond, the N terminal is acylated, and X represents lauric acid or palmitic acid.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to an erythropoietin mimic peptide. An agonistic erythropoietin mimetic peptide and a preparation method thereof. The present invention also relates to the use of the mimetic peptide in the preparation of medicines for treating diseases characterized by the lack of erythropoietin or the absence or deficiency of red blood cell populations. Background technique

[0002] Erythropoietin (EPO) is a glycoprotein hormone with a molecular weight of about 34kD. The erythropoietin present in the plasma is composed of 165 amino acids, with a high degree of glycosylation, and the main sugar component is sialic acid. According to different carbohydrate content, naturally occurring erythropoietin is divided into two types, α-type and β-type, among which, α-type contains 34% carbohydrates, and β-type contains 26% carbohydrates. The two types are identical in biological characteristics, antigenicity and ...

Claims

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