Hydroxyethyl starch modified hemopoietin mimic peptide and preparation thereof and application thereof

A technology of erythropoietin and hydroxyethyl starch, applied in the field of biomedicine, can solve problems such as low EC50 and limitation, and achieve the effect of prolonging half-life
CN105418754AInactive Publication Date: 2016-03-23TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2016-03-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a hydroxyethyl starch modified hemopoietin mimic peptide with a long-acting erythropoiesis promoting function and a medicinal salt thereof. The invention further provides a preparation method for the hydroxyethyl starch modified hemopoietin mimic peptide and use thereof in preparing drugs for treating diseases which are characterized by being short of erythrocyte and erythrogenin or being short of erythrocyte groups or being in defect of erythrocyte groups. The hydroxyethyl starch modified hemopoietin mimic peptide provided by the invention is represented by a formula I as shown in the description, wherein two cysteines form a disulfide bond, X represents succinic hydroxyethyl starch, C represents a lysine at a tail end, and (K) is condensed with carboxyl of X through free amino of a side chain.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to a erythropoietin mimic peptide modified by hydroxyethyl starch. Specifically, the present invention relates to a hydroxyethyl starch-modified erythropoietin mimetic peptide capable of binding to erythropoietin receptors and activating erythropoietin receptors or having an agonistic effect on erythropoietin and its The preparation method, the present invention also relates to the use of the mimetic peptide in the preparation of medicines for the treatment of diseases characterized by the lack of erythropoietin or the absence or defect of red blood cell population. Background technique

[0002] Erythropoietin (EPO) is a glycoprotein hormone. The human erythropoietin gene is located in the long 22 region of chromosome 7. In 1985, its cDNA was successfully cloned, and recombinant human erythropoietin (rHuEPO) was produced in large quantities using gene recombination technology, which was wi...

Claims

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