Treatment method and system for recycling tetrahydrofuran in solution discharged in parecoxib normal-phase workshop section

Abstract

The invention discloses a treatment method and system for recycling tetrahydrofuran in a solution discharged in a parecoxib normal-phase workshop section. The treatment system comprises a waste liquid storage tank, a lifting pump, a membrane separation device, a condensation recycling device, a tetrahydrofuran collection tank and a vacuum pump device. The waste liquid storage tank is connected with the lifting pump, the lifting pump is connected with a liquid inlet of the membrane separation device through a pipeline, a liquid outlet of the membrane separation device is connected with the waste liquid storage tank, a gas outlet of the membrane separation device is connected with the condensation recycling device, a liquid outlet of the condensation recycling device is connected with the tetrahydrofuran collection tank, a gas outlet of the condensation recycling device is connected with the vacuum pump device, and the vacuum pump device is connected with the membrane separation device. Compared with the traditional art, the treatment way of recycling tetrahydrofuran in the solution discharged in the parecoxib normal-phase workshop section is charged, secondary pollution is avoided, no distillation still residual liquid is produced, the purity of separated-out tetrahydrofuran is high, the tetrahydrofuran is directly reused in a front end production process, the whole process is carried out at the temperature smaller than 70 DEG C, a product in the solution will not be damaged, and the running cost is low.

Description

technical field [0001] The invention relates to a sewage treatment process and equipment thereof, in particular to a treatment method and system for recovering tetrahydrofuran from solution discharged from a parecoxib normal phase section. Background technique [0002] Parecoxib is a cyclooxygenase-2 (COX-2) specific inhibitor. Coxib analgesics belonging to anti-arthritic drugs. [0003] The synthesis of parecoxib drug includes: centrifugal section, normal phase section and reverse phase section. In the normal phase section, the filtrate after the reaction is a production waste liquid containing high concentrations of tetrahydrofuran and ethyl acetate. Waste liquid components include: THF 88.00% (W / W), ethyl acetate 11.00% (W / W), by-products 1.00% (W / W), and other substances in trace amounts. The conventional treatment method for this kind of waste liquid is rectification under reduced pressure to recover tetrahydrofuran, but since ethyl acetate and tetrahydrofuran will v...

AI Technical Summary

Problems solved by technology

The conventional treatment method for this kind of waste liquid is rectification under reduced pressure to recover tetrahydrofuran, but since ethyl acetate and tetrahydrofuran will volatilize into organic gas at the same time during the distillation process, the inorganic gas will be completely separated.

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