Seminal plasma piRNA markers or their combination for detecting and/or predicting male reproductive dysfunction and application thereof

A reproductive function and marker technology, applied in DNA/RNA fragmentation, recombinant DNA technology, microbial determination/inspection, etc., can solve problems such as semen quality that cannot directly reflect testicular spermatogenesis
CN105483218AActive Publication Date: 2016-04-13NANJING YOUZHIYUAN PHARMACEUTICAL TECHNOLOGY CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING YOUZHIYUAN PHARMACEUTICAL TECHNOLOGY CO LTD
Publication Date
2016-04-13

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Abstract

The invention discloses seminal plasma piRNA markers or their combination for detecting and / or predicting male reproductive dysfunction and application thereof. The piRNA markers or their combination are 61 in quantity and mainly include piR-31068, piR-31925, piR-43771, piR-43773 and piR-30198; this combination can be used to detect and / or predict asthenospermia and azoospermia. In the invention, seminal plasma is easy to obtain, no other tissues are required, and examinations are noninvasive; seminal plasma piRNA can indicate pathological and biological conditions of a whole spermatogenic stage, accuracy level of detection can be increased using the seminal plasma piRNA as auxiliary detection indexes, the pathological and biological conditions the whole spermatogenic process are indicated on molecular level, and a latent target is provided for the diagnosis and treatment of male reproductive dysfunction.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to seminal plasma piRNA markers or combinations thereof for detecting and / or predicting male reproductive dysfunction and applications thereof. Background technique

[0002] Male infertility has become a reproductive health problem worldwide. According to estimates from the World Health Organization, there are currently nearly 80 million infertile (pregnant) couples in the world, accounting for about 8% to 12% of couples of childbearing age, of which male factors account for about 30%. % to 40% (1,2), and 60% to 75% of male factor infertility the etiology is unknown (3). In recent years, the proportion of male infertility has been on the rise, and people have higher and higher requirements for prenatal and postnatal care. Therefore, in order to effectively diagnose and treat male infertility, it is urgent to find male infertility markers with higher clinical value.

[0003] However, ther...

Claims

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