Applications of tupaia belangeri in preparation of Alzheimer's disease model

A technology for Alzheimer's disease and disease model, which is applied in the application field of tree shrew in the preparation of Alzheimer's disease model, and can solve the problem that there is no very clear method.

Inactive Publication Date: 2016-04-20
GUANGXI MEDICAL UNIVERSITY
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  • Applications of tupaia belangeri in preparation of Alzheimer's disease model
  • Applications of tupaia belangeri in preparation of Alzheimer's disease model

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[0026] The present invention will be further described in detail below in conjunction with specific embodiments, and the given examples are only for clarifying the present invention, not for limiting the scope of the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0027] The tree shrews in the following examples are all Dianxia species.

[0028] 1 material

[0029] 1.1 Experimental animals

[0030] Tree shrews (Dianxi species), male, 30, 3 months old, body weight 120g±10g, provided by Experimental Animal Center of Kunming Medical College. Experimental animal production license number: SCXK (Dian) 2013-0002.

[0031] 1.2 Main reagents and instruments

[0032] β-amyloid 1-42 (Aβ1-42), ibotenic acid (ibotenic acid, Ibo), D-galactose (D-gal) produced by Sigma, USA; the concent...

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Abstract

The invention discloses applications of tupaia belangeri in preparation of an Alzheimer's disease model. The technical scheme is as follows: S1, an application of the tupaia belangeri, D-galactose, beta-amyloid protein1-42, ibotenic acid and pentobarbital sodium in preparation of the Alzheimer's disease animal model; S2, an application of the tupaia belangeri, D-galactose, beta-amyloid protein1-42, ibotenic acid and pentobarbital sodium in preparation of a tupaia belangeri disease model with at least one of following characteristics: 1), gliocyte proliferation; 2), neurofibril entanglement; 3), learning and memory ability deterioration.

Description

technical field [0001] The invention relates to the application of tree shrews in preparing animal disease models, in particular to the application of tree shrews in preparing Alzheimer's disease models. Background technique [0002] Tree shrews (Tupaia belangeri) belong to the tree shrew order Tree shrew family tree shrew animals, distributed in Southeast Asian countries. In mainland China, it is distributed in Guangxi, Hainan, Guizhou, Yunnan, Sichuan, Tibet and other places, mainly living in tropical and subtropical forests, shrubs, and near villages. [0003] Alzheimer's disease (AD) is a neurological disease that threatens human health. At present, there is no clear method for the treatment of AD. Establishing a good AD animal model is helpful for understanding the etiology and pathogenesis of AD, and can guide the prevention and treatment of AD. The current AD models are divided into two categories: primate models and rodent models. Primate models are expensive, an...

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Application Information

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IPC IPC(8): A61K49/00A01K67/02
CPCA01K67/02A61K49/0008
Inventor 欧阳轶强梁振鑫
Owner GUANGXI MEDICAL UNIVERSITY
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