Apparatus and method for aerosol delivery to the lungs or other locations of the body

Abstract

This invention relates to an apparatus useful for the delivery of aerosols, such as those containing drugs, to the lungs or other locations in the body. The apparatus comprises a storage in liquid communication with an outlet path; a low-pressure pump inlet in liquid communication with the outlet path, a high pressure pump in liquid communication with the low-pressure pump inlet, a high pressure pump outlet in liquid communication with the high pressure pump, a switch valve in liquid communication with the high pressure pump outlet, with the switch valve being provided with a delivery outlet and a release outlet, and an aerosolizer in liquid communication with the delivery outlet, wherein an end wall of the aerosolizer is provided with holes, and a liquid flowing from the outlet path to the holes is free of gas when the storage contains the liquid. The disclosure also relates to methods of administering an aerosol to the lungs or other locations in the body of a patient. The method includes a) providing the apparatus, b) arranging the aerosolizer and a target tissue in the patient which are adjacent and c) applying the aerosol to the patient.

Description

[0001] This divisional application is based on the division of the original Chinese patent application with the application number 201180023064.8, the application date is January 25, 2011, and the title of the invention is "Apparatus and method for delivering aerosol to the lungs or other parts of the body". case application. technical field [0002] The present description relates to devices for delivering aerosols, such as those comprising drugs and / or biologically active agents (eg, drugs), to the lungs or other locations in the body. The specification also relates to methods of administering aerosols to the lungs or other locations in a patient using the disclosed devices. Background of the invention [0003] Aerosols represent an important delivery form for administering pharmaceutically active agents to patients. Typically, an aerosol is a homogeneous colloidal mixture comprising a dispersed phase and a continuous gaseous medium. [0004] An example of an aerosol is ...

AI Technical Summary

Problems solved by technology

They do not protect the nose, mouth, throat, trachea, or other sensitive tissues in the airways from exposure to drugs that could be dangerous or damaging to healthy tissue if inhaled, such as nebulized chemotherapy

Small particle sizes from inhalation therapy are also more likely to be exhaled by patients, contaminating the environment and potentially harming healthcare providers

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