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Microneedle patches, systems and methods

A technology of microneedle stickers and microneedles, which is applied in the direction of microneedles, needles, and other medical devices, and can solve problems such as expensive, troublesome users, and unsatisfactory

Active Publication Date: 2020-07-24
GEORGIA TECH RES CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The separate, complex applicator is used to manipulate the microneedle patch and apply it to the patient, and may be cumbersome for the user, bulky, expensive for a single use, and / or due to Cross-contamination issues are not ideal for multi-person administration (e.g., mass vaccination)

Method used

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  • Microneedle patches, systems and methods
  • Microneedle patches, systems and methods
  • Microneedle patches, systems and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Example 1: Fabrication of microneedle patches with mechanical force indicators

[0127] Etched, stainless steel microneedles were mounted on an adhesive foam backing (TM9942, MacTac, Stow, OH) and packed in polyacetal. Each patch has 50 hexagonally packed microneedles, 750 μm long, with a row and column spacing of 1.6 and 1.0 mm, respectively. Parts were assembled with double sided tape (1522, 3M, Minneapolis, MN) and sent for ethylene oxide sterilization.

[0128] Fabricate a mechanical force indicator to facilitate microneedle insertion. These devices were evaluated using a resistant strain gauge load cell (RSP1-010M-A, Loadstar Sensors, Fremont, CA) compared to the force used by an experienced blinded investigator to insert the microneedle patch. The mechanical force indicator consisted of a polypropylene screw cap (91620A200, McMaster-Carr, Atlanta, GA), cardstock, and double-sided tape (1522, 3M, Minneapolis, MN). Apply the tape to the cardstock, cut into 14mm c...

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Abstract

Embodiments of the present application provide microneedle patches and systems and methods of using such patches and systems. In one aspect, a microneedle patch is provided that includes a tab portion for manipulating the microneedle patch. In another aspect, a system is provided that includes a microneedle patch and a tray for housing the microneedle patch. In another aspect, various indicators are provided for providing feedback before, during and after microneedle patch application. Advantageously, the described microneedle patch and system would provide improved handling and easy application of the microneedle patch to the skin to deliver therapeutic agents.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Patent Application No. 61 / 884,396, filed September 30, 2013, U.S. Provisional Patent Application No. 62 / 024,062, filed July 14, 2014, and U.S. Provisional Patent Application No. 6, filed July 25, 2014 62 / 029,202, the disclosure of which is incorporated herein by reference. [0003] Statement Regarding Federally Funded Research or Development [0004] This application was made with United States Government support under Contract No. U01EB012495 awarded by the National Institutes of Health. technical field [0005] This application is generally in the field of microneedle patches that transport therapeutic molecules or biomolecules into the skin or across tissue barriers. Background technique [0006] Transdermal drug delivery offers several advantages over other methods of administering drug formulations to patients. One approach for transdermal drug delivery involves the u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M2037/0023A61M2037/0046A61M2037/0061A61M37/0015A61M37/00A61M2205/581A61M2205/582A61M2205/583A61M2205/586
Inventor 德文·麦卡利斯特马克·普劳斯尼茨塞巴斯蒂安·亨利詹姆斯·J·诺曼
Owner GEORGIA TECH RES CORP