BDZL (bendazac lysine) eye drops

A technology of benzyl lysine and eye drops, which is applied in the field of pharmaceutical preparations, can solve the problems of patients being unbearable, affecting the curative effect, and large irritation, and achieve the effects of improved bioavailability, stable therapeutic effect, and quick effect

Inactive Publication Date: 2016-06-22
GUANGDONG YIMING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The biggest disadvantage of the listed benzyl lysine eye drops is: strong irritation, local irritation including burning sensation and r

Method used

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  • BDZL (bendazac lysine) eye drops
  • BDZL (bendazac lysine) eye drops
  • BDZL (bendazac lysine) eye drops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] The following specific examples illustrate the present invention in detail.

[0027] Embodiment and comparative example are shown in the following table 1:

[0028] Table 1: (unit: part)

[0029]

[0030] (1) According to the "Technical Guidelines for Stability Research of Chemical Drugs", the accelerated test is carried out. Test sample 1 (sample 1 was prepared according to the ratio of Example 3) was subjected to an accelerated test for 6 months under the conditions of 40°C±2°C and RH20%±5%. , 6-month sampling inspection indicators.

[0031] Table 2: Accelerated test results

[0032]

[0033] Conclusion: The detection results of the accelerated test show that the quality of the Bendalysine eye drops prepared in Example 3 of the present invention is stable.

[0034] (2) Comparison of the irritation of Bendalysine Eye Drops with the same type of products on the market

[0035] Validation design: A total of 10 healthy volunteers were used to compare the left a...

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Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to BDZL (bendazac lysine) eye drops. The BDZL eye drops are used for preventing and treating senile cataract and are prepared from components in parts by mass as follows: 2-3 parts of BDZL, 0.02-0.03 parts of polysorbate-60, 0.01-0.02 parts of polysorbate-20, 0.15-0.25 parts of benzalkonium chloride, 2-2.5 parts of monosodium phosphate, 6-6.5 parts of sodium hydrogen phosphate, 0.1-0.15 parts of methyl 4-hydroxybenzoate, 0.05-0.15 parts of C25H25O6N2Zn and up to 1,000 parts of water for injection. The BDZL eye drops have the advantages that the quality is stable, irritation for eyes is remarkably lower than that of like products sold in the market, the bioavailability is improved remarkably by means of the effective component BDZL under matching of C25H25O6N2Zn, the absorption is good, the effect is taken rapidly, and the treatment effect is stable.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a Bendax lysine eye drop, which is used for preventing and treating cataract. Background technique [0002] Cataract is caused by various reasons such as aging, genetics, local nutritional disorders, immune and metabolic abnormalities, trauma, poisoning, radiation, etc., which can cause lens metabolic disorders, resulting in lens protein denaturation and turbidity. At this time, the light is blocked by the turbid lens. Projected on the retina, objects cannot be seen clearly. From the perspective of preventing and treating blindness in groups, the World Health Organization degeneration and opacity of the lens becomes opaque, so as to affect vision, and those whose corrected vision is 0.7 or below are included in the scope of cataract diagnosis. Cataract (senile cataract) is one of the most common eye diseases and is the number one cause of blindness in the wor...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/416A61K47/22A61P27/12
CPCA61K9/08A61K9/0048A61K31/416A61K47/22
Inventor 李易春
Owner GUANGDONG YIMING PHARMA
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